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Early administration of antibiotics for open fractures can reduce serious bone and soft tissue infections, with a common goal being antibiotic administration within one hour of injury.
In this study, there were 523 patients treated by EMS who had an open extremity fracture.
The median time from EMS dispatch until antibiotic administration was 31 minutes. 99% of the patients who received antibiotics received them within one hour of EMS dispatch. Prehospital times were on average 10 minutes longer for those patients who received antibiotics. The majority of these patients received cefazolin, followed by ceftriaxone, ampicillin, gentamicin and piperacillin/tazobactam. None of these patients required management for an allergic reaction or anaphylaxis. Five patients (1%) who received prehospital antibiotics and 159 patients who did not (1.4%) had a subsequent infection based on ICD codes.
Bottom line: In this small group, it was safe to administer antibiotics to a patient with an isolated open extremity fracture and the medication was able to be delivered earlier. Larger studies will be needed to see the impact of this practice on the development of osteomyelitis or soft tissue infections.
References
Muniz AD, Gregorio DJ, Studebaker SA, et al. Time Savings and Safety of EMS Administration of Antibiotics for Open Fractures. Prehosp Emerg Care. Published online April 25, 2024. doi:10.1080/10903127.2024.2347291