Search
Direct hepatotoxicity from a drug is predictable and dose-dependent.
Most commonly implicated agents include:
- Acetaminophen
- Niacin
- Aspirin
- Cocaine
- IV Amiodarone
- IV methotrexate
- Cancer chemotherapy
On the contrary, idiosyncratic prescription drug-induce liver injury is rare, unpredictable and not related to dose.
Most commonly implicated agents are:
- Amoxicillin-clavulanate
- Isoniazid
- Nitrofurantoin
- TMP-SMZ
- Miocycline
- Cefazolin
- Azithromycin
Bottom line:
- Drug-induced liver injury is uncommon and can be a diagnostic challenge.
- Recognition of commonly implicated agents can help recognize/identify drug-induced liver injury.