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Levetiracetam
- A new anticonvulsant that is 100% renally eliminated
- Does not require therapeutic drug monitoring like phenytoin
- The IV form does not cause skin necrosis or have cardiotoxicity like phenytoin
- Is being investigated in benzodiazepine-refracory status epilepticus (1)
- Fairly safe drug even in overdose (Barrueto et al ;) )
Knake et al. Intravenous levetriacetam in thetreatment of benzodiazepine-refractory status epilepticus. J Neurol Neurosurg Psychiatry 2007 Sept 26; Epub