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Everything you need to know about anti-emetics, mechanism of action, potency and toxicity:
1) 5-HT3 Blockers - Ondansetron, Granistron
- The most potent anti-emetic, only toxicity is really cost
2) Dopamine Blockers - Metoclopramide
- Can titrate to high doses, causes dystonia, akathisia and mild QT prolongation
3) Anticholinergic - Promethazine, meclizine, diphenhydramine
- Cannot titrate, most sedating, urinary retention in elderly, mild QT prolongation