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- Takayasu arteritis (TA) is a granulomatous vasculitis that affects the aorta and its major branches
- Involvement of the aortic arch is associated w/CNS symptoms, claudication, absent peripheral pulses, and cardiac manifestations
- The EULAR/PReS consensus criteria for Dx of childhood TA requires characteristic angiographic abnormalities of the aorta plus 1 of the following:
- Absent peripheral pulses or claudication
- Blood pressure discrepancy in any limb
- Bruits
- Hypertension
- Elevated acute phase reactants
- Gold standard for Dx is angiography; however, CT and MR angiograms are less invasive and can detect inflammation & luminal diameter changes
- Tx is challenging, steroids may induce remission in up to 60%
References
Weiss P, et al. Pediatric vasculitis. The Pediatric clinics of North America. April 2012:59;2:407-423.