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Cyclophosphamide-induced hemorrhagic cystitis is a well known to oncologists. This unique complication of this chemotherapeutic drug has a defined mechanism and could be seen in your Emergency Department.
- Hemorrhagic cystitis occurs in 46% of patients that receive cyclophosphamide
- Can occur even months after administration
- 5% can actually die from the hemorrhage
- Treatment: Bladder irrigation, hydration, supportive. Oral adminsitration of MESNA (2mercaptoethan sulfonate) and bladder irrigation with prostaglandins and even methylene blue have been attempted.