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Kawasaki disease (KD) is the leading cause of acquired heart disease in North American & Japanese children
Children w/KD should undergo a 2-D echocardiogram and electrocardiogram
In the acute phase, the myocardium, pericardium, endocardium, valves, conduction system, and coronary arteries may all be involved
KD shock syndrome is a cardiovascular manifestation that presents with hypotension, LV systolic dysfunction, coronary artery aneurysm, and a shocklike state
AHA recommends KD tx w/a single dose of 2 g/kg of IVIG infused over 12 hours plus high-dose aspirin at a dose of 80 to 100 mg/kg per day in 4 divided doses
More than 50% of coronary artery aneurysms regress within the first 2 years of onset
Regression is associated with marked thickening of the intima, which may later stimulate atherosclerosis with a risk for ischemic heart disease
References
Scuccimarri R. Kawasaki Disease. Pediatric Clin N Am 59(2012)425-445