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Autosomal dominant inherited arrhythmic disorder characterized by mutation in sodium-channels
Arrhythmic events are often observed at rest or while asleep, resulting in VF and SCD
Diagnostic criteria consists of 2 parts: (1) ECG abnormalities (2) clinical characteristics
A. ECG abnormalities: incomplete or complete RBBB in right precordial leads (V1-V2) w/
Type I coved-type ST segment elevation and negative T wave
Type II saddle-back ST segment elevation followed by a positive or biphasic T wave
Type III ST segment elevation without meeting criteria for type I or II variants
B. Clinical characteristics: hx of VT/ VF, family hx of SCD or abnormal ECG, agonal respirations during sleep, or inducible VT/VF during EP study
References
Mizusawa Y, Wilde A. Brugada Syndrome. Circ Arrhythm Electrophysiol. 2012;5:606-616.