Search
Protamine for enoxaparin overdose
- Protamine may be used to treat severe cases of hemorrhage in enoxaparin overdose
- Protamine reverses the prolonged aPTT, but fails to completely reverse the anti-Xa effect (reverses about 60%)
- Administer protamine by slow IV to equal the dose of enoxaparin injected: (1:1 ratio)
- if < 8 hours after last dose enoxaparin, give 1 mg protamine per 1 mg enoxaparin;
- if 8-12 hours after last dose enoxaparin, give 0.5 mg protamine per 1 mg enoxaparin;
- if >12 hours after last dose of enoxaparin, protamine is not required