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Salicylates:
- stimulate the respiratory center in the brainstem, causing respiratory alkalosis
- interfere with the Krebs cycle, limiting ATP production, leading to an anaerobic metabolism
- uncouple oxidative phosphorylation, causing accumulation of pyruvic and lactic acid and heat production, resulting in acidosis and hyperthermia
- increase fatty acid metabolism, generating ketone bodies
Overall, this results in a mixed respiratory alkalosis and metabolic acidosis.
References
Micromedex; Poisindex, salicylate poisoning.