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The incidence of tendon rupture related to fluoroquinolone use is reported to be in the range of 1 in 6000.
The risk of tendon rupture associated with FQ use is increased in those older than 60 years of age, those taking steroids, and in patients who have received heart, renal, or pulmonary transplants.
There is no evidence that tendon rupture is more likely for patients taking levofloxacin compared to other FQs.
References
The Medical Letter 2011;53(1368):55-56.