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Patients with pericarditis are generally treated with high-dose aspirin (e.g. 2-4 gms/day) or other NSAIDs in high dose. However, when myocarditis is also present (e.g. elevated TN levels), lower dosages of aspirin (e.g. 500 mg TID) or other NSAIDS should be used. The higher dosages of anti-inflammatory medications in the setting of myocarditis are thought to exacerbate the myocarditic process and increase mortality (animal studies).
Imazio M, Spodick DH, Brucato A, et al. Controversial Issues in the management of pericardial diseases. Circulation 2010;121:916-928.