1-1 of 1 results by Scott Sparks
Reducing 28-day all-cause mortality compared to conventional MAP management in sepsis patients requiring vasopressors after initial resuscitation.
- Cardiac output, MAP, and organ-specific vascular resistance determine organ perfusion.
- SEPSISPAM trial showed that a higher MAP reduced need for renal replacement therapy.
- An elevated Renal Resistive-Index (RRI) > 0.7 is associated with impaired perfusion, development of AKI, and increased MR.
- The kidney is a low vascular resistance organ sensitive to hypoperfusion in sepsis.
- 28-day all-cause MR and ventilator free days was decreased.
- RRI-guided MAP titration did not specifically decrease MR, incidence of AKI or need for CRRT.
- Although a pilot trial, this study lends credence to more individualized sepsis hemodynamic management and the need for a larger study.
- Use of RRI-guided MAP titration in sepsis may decrease overall 28-day MR.
- How to Guide. https://ultrasoundpaedia.com/renal-arteries-normal/
