Our Mission
The Disease Modeling Unit (DMU) is central to CPDM@UMB’s mission, driving the development of precision disease models that translate genetic discoveries into mechanistic insights and therapeutic advancements. The DMU’s major goals include:
- Evaluating Variant Feasibility: Assessing the suitability of genetic variants for modeling across Drosophila, zebrafish, and mouse platforms.
- Precision Disease Model Generation: Creating high-throughput Drosophila models for initial validation and advancing clinically significant findings to zebrafish and mouse models for deeper analysis.
- Causal Association and Mechanistic Studies: Establishing causal links between genetic variants and disease phenotypes through phenotypic assays and multi-omics analyses.
- Therapeutic Development and Testing: Collaborating with the Preclinical Section to develop and test targeted, mechanism-based treatments in Tier 1 and Tier 2 models.
Roles of the Disease Modeling Unit and its interaction with the other center sections
Organizational Chart
