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Division of Infectious Disease & Tropical Pediatrics

Mission

Improve the health of children by promoting excellence in diagnosis, management, and prevention of infectious diseases through clinical care, education, research, advocacy, and training.


Clinical Services

Our clinical services include comprehensive inpatient and outpatient consultations to children with proven or suspected infections. We develop and interpret diagnostic evaluations and formulate management plans, including recommendations for type and duration of antimicrobial therapy. We evaluate children who present with uncertain diagnoses, recurrent or persistent infections, or with complicated infections.

Research

Our investigators lead large domestic and international projects. On a national scale, we are one of nine sites in the U.S. contracted by the National Institute of Allergy and Infectious Disease (NIAID) to run a Vaccine Treatment and Evaluation Unit (VTEU) that performs clinical trials and detailed immunologic assessments of vaccines against infectious diseases of public health importance. We are also one of six sites in the U.S. with a large U19 from NIAID to run a Cooperative Center for Human Immunology (CCHI) focused in understanding human immune responses to infectious agents and the basis of immune protection. We are testing new vaccines to prevent RSV and improved vaccines for meningococcus and measles. At our CVD-Mali field site, we are conducting clinical trials of vaccines against Ebola and meningococcus and are examining the effectiveness of vaccinating pregnant women against pertussis (whooping cough) to protect their newborns. We are conducting large studies of the causes, outcomes, and treatment of diarrheal illnesses and mortality in young children.

At our field site in Malawi, Central Africa, and with our collaborators in Burkina Faso, we are evaluating a new typhoid fever vaccine, including conducting large-scale epidemiological and immunological studies.

Our team of malaria researchers work in Mali, Malawi, and Burkina Faso leading malaria vaccine trials, large-scale epidemiological and immunological studies, and clinical trials evaluating strategies to prevent malaria in pregnancy and HIV-malaria interactions. We are leading clinical and translational research to understand the pathophysiology of severe malaria. Our well-established research sites provide a platform for additional areas of research such as examining the impact of HIV exposure during pregnancy on infant immune responses to vaccines.

 

Research Facilities

Pediatric vaccine trials are conducted at the CVD outpatient facilities and within private pediatric practices in the Baltimore-Washington metropolitan area.

We maintain field sites for clinical trials and epidemiological studies in Mali (CVD-Mali) and Blantyre, Malawi (Blantyre Malaria Project) in addition to our collaborations with other sites in sub-Saharan Africa in The Gambia, Kenya, Burkina Faso, and in South Asia (Bangladesh).

Basic and translational studies are performed in the CVD laboratories and in collaboration with partner institutions to promote capacity-building.


Education

Click on the link above to learn more about the T32 Training Grant in Vaccinology or review the T32 fact sheet.


Faculty

Clinical Faculty

Click on the faculty member's name to view their web page.

  • Andrea Berry, MD
    Academic Title: Assistant Professor of Pediatrics and Medicine

    Dr. Berry conducts clinical trials designed to evaluate new and improved pediatric vaccines among children in Baltimore. In addition, she is conducting research on immune responses to malaria infection and vaccination.

  • James D. Campbell, MD, MS
    Academic Title: Professor of Pediatrics

    Dr. Campbell's research interests include the performance of clinical trials of vaccines in all age groups, the investigation of the epidemiology of vaccine-preventable diseases, and HIV prevention.
  • Karen L. Kotloff, MD
    Academic Title: Professor of Pediatrics and Medicine
    Administrative Title: Division Head, Pediatric Infectious Diseases and Tropical Medicine

    Dr. Kotloff is Principal Investigator of the NIAID-sponsored Vaccine Testing and Evaluation Unit, for which she led two of the nation’s first studies of the 2009 H1N1 influenza virus vaccine in both children and adults (see video here). She also performs pediatric clinical trials and epidemiologic studies in developing countries.
  • Miriam K. Laufer, MD, MPH
    Academic Title:Associate Professor of Pediatrics, Medicine, Epidemiology & Public Health
    Administrative Title: Associate Director for Malaria Research

    Dr. Laufer conducts clinical trials in Malawi focusing on the epidemiology of drug-resistant malaria, malaria-HIV interactions, and the interaction between malaria and pregnancy.
  • Matthew Laurens, MD, MPH
    Academic Title: Associate Professor of Pediatrics and Medicine

    Dr. Laurens’ research interests include malaria-HIV interactions, malaria vaccine trials, malaria challenge studies, and correlates of protection against malaria infection and disease.
  • Monica A. McArthur, MD, PhD
    Academic Title:
    Assistant Professor of Pediatrics

    Dr. McArthur's research interests include the interactions between pathogens and the human immune system. She is particularly interested in T cell responses against infectious agents affecting children in the developing world.

    Currently, Dr. McArthur is leading the Zika vaccine clinical trial at the University of Maryland CVD.  She is also involved in several translational human immunology projects studying T cell responses against Vibrio cholerae, Enterotoxigenic Escherichia coli (ETEC), and flaviviruses (including Zika, dengue, and yellow fever viruses).

  • Milagritos Tapia, MD
    Academic Title: Associate Professor of Pediatrics and Medicine

    Dr. Tapia conducts epidemiologic studies and vaccine trials at CVD-Mali.
  • Mark Travassos, MD
    Academic Title: Assistant Professor of Pediatrics and Medicine

    Dr. Travassos’ research interest is malaria. He is using molecular techniques to assess the role of variant antigen switching in the development of symptomatic malaria.

Research Faculty

Click on the faculty member's name to view their web page.

  • Myron M. Levine, MD, DTPH
    Academic Title: Simon and Bessie Grollman Distinguished Professor of Medicine and Microbiology and Immunology, Epidemiology & Public Health, Pediatrics
    Administrative Title: Associate Dean for Global Health, Vaccinology and Infectious Diseases

    Dr. Levine’s world-renowned research involves studies of pathogenesis and vaccine development and the assessment of a variety of vaccines in adults and children in Baltimore, as well as in many developing countries. He conducted pivotal trials leading to licensure of vaccines to prevent typhoid fever and cholera. He is the recipient of the Albert B. Sabin Gold Medal Award for lifetime achievement in the area of vaccine development and implementation.
  • Rosangela Mezghanni, PhD
    Academic Title: Associate Professor of Pediatrics

    Dr. Mezghanni performs research to detail the different types of immune responses that occur after exposure to infection and vaccination, and the cellular signals that regulate these responses. She is developing an organotypic model of the human intestinal mucosa.
  • Marcela Pasetti, PhD
    Academic Title: Professor of Pediatrics and Microbiology and Immunology

    Dr. Pasetti’s research focuses on characterizing immune responses to vaccination in young infants and children and evaluating the humoral immune responses to vaccination in clinical trials.
  • Marcelo B. Sztein, MD
    Academic Title: Professor of Pediatrics and Medicine, Microbiology and Immunology

    Dr. Sztein’s research focuses on understanding the immunologic correlates of protection in the context of vaccine development.
  • Rezwanul Wahid, MBBS, PhD
    Academic Title: Assistant Professor of Pediatrics

    Dr. Wahid studies T and B cell mediated host-immune responses and induction immune memory by immunization with licensed or candidate vaccines in humans. He primarily utilizes the clinical samples obtained from volunteers participating in various vaccine trials.

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