The Radiation Oncology-Biology Integration Network Oligometastasis (ROBIN OligoMET) Center is focused on understanding how radiation therapy can affect the metastatic process, particularly in low-volume or oligometastatic prostate cancer (PCa).
Our center brings together in-depth experience, knowledge, and high-level skills to study mechanisms of how radiation therapy (RT) can affect the metastatic process. This collaborative effort spans the following institutions:
- University of Maryland Baltimore (UMB)
- Weill Cornell Medicine (WCM)
- Thomas Jefferson University (TJU)
- The University of Texas MD Anderson Cancer Center (MDACC)
This multidisciplinary perspective enables us to bring the latest clinical trials, profiling and computational methods to bear on the most clinically relevant aspects of oligometastasis. The projects integrate state-of-the-art tissue, liquid and radiomic multi-parametric profiling techniques from humans complimented with syngeneic mouse tumor models in the context of a first-in-man phase II randomized trial. Data will be integrated using novel network methods to prioritize candidates for functional validation across projects.
Principal Investigators
This U54 ROBIN OligoMET Center is led by Drs. Amit Sawant (University of Maryland), Phuoc Tran (MD Anderson), and Nicole Simone (Thomas Jefferson University).
Amit Sawant, PhD
Professor of Radiation Oncology
Vice Chair for Medical Physics
Department of Radiation Oncology
University of Maryland School of Medicine
Phuoc T. Tran, MD, PhD
Professor and Chair, Genitourinary Radiation Oncology
Department of Genitourinary Radiation Oncology
Division of Radiation Oncology
The University of Texas MD Anderson Cancer Center
Adjunct Professor, Department of Radiation Oncology
University of Maryland School of Medicine
Nicole Simone, MD, PhD
Margaret Q. Landenberger Professor
Vice Chair, Research & Faculty Development
Sidney Kimmel Medical College at Thomas Jefferson University
Research Team
Project 1 (genomics, radiomics and liquid biopsies) is led by Drs. Sawant, Tran, and Ren; Project 2 (metabolomics and disparities) is led by Dr. Simone; and the Resource Sharing and Cross-Training Cores are led by Drs. Luigi Marchionni, Sawant and Ren. To learn more about all of our researchers and projects, visit the Our Teams page.
Contact
For more information, please contact Amit Sawant, PHD, at asawant@som.umaryland.edu.
