Publications
2020 - Present
Bhat SA, Henry RJ, Blanchard AC, Stoica BA, Loane DJ, Faden AI. Enhanced Akt/GSK-3β/CREB signaling mediates the anti-inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice. J Neurochem. 2020 Jan 11:e14954. [Epub ahead of print] PMID: 31926033.
Barrett JP, Henry RJ, Ann Shirey K, Doran SJ, Makarevich OD, Ritzel RR, Meadows VA, Vogel SN, Faden AI, Stoica BA, Loane DJ. Interferon-β plays a detrimental role in experimental traumatic brain injury by enhancing neuroinflammation that drives chronic neurodegeneration. J Neurosci. 2020 Feb 5. pii: 2516-19. [Epub ahead of print] PMID: 3202953.
Henry RJ, Ritzel RM, Barrett JP, Doran SJ, Jiao Y, Leach JB, Szeto GL, Stoica BA, Faden AI, Loan DJ. Microglial depletion with CSF1R inhibitor during chronic phase of experimental traumatic brain injury reduces neurodegeneration and neurological deficits. J Neurosci . J Neurosci. 2020 Feb 24. pii: 2402-19. [Epub ahead of print] PMID: 32094203.
Ritzel RM, Li Y, He J, Khan N, Doran SJ, Faden AI, Wu J. Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury. Neurobiol Dis. 2020 Mar; 136:104713. PMID: 31843705.
Thayer JA, Awad O, Hegdekar N, Sarkar C, Tesfay H, Burt C, Feldman RA and Lipinski MM. The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability. Autophagy. 2020;16(1):140-152. PMID: 30957634.
Doran SJ, Henry RJ, Shirey KA, Barrett JP, Ritzel RM, Lai W, Blanco JC, Faden AI, Vogel SN, Loane DJ. Early or late bacterial lung infection increases mortality after traumatic brain injury in male mice and chronically impairs monocyte innate immune function. Crit Care Med . 2020 Mar 5. [Epub ahead of print] PMID: 32149839.
Henry RJ, Doran SJ, Barrett JP, Meadows VE, Sabirzhanov B, Stoica BA, Loane DJ, Faden AI. Inhibition of miR-155 limits neuroinflammation and improves functional recovery after experimental traumatic brain injury in mice. Neurotherapeutics (in press).
Cao T, Matyas JJ, Renn CL, Faden AI, Dorsey SG, Wu J. Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain. Cells. 2020;9(5):E1194. 2020 May 11. PMID: 32403409.
Sabirzhanov B, Makarevich O, Barrett J, Jackson IL, Faden AI, Stoica BA. Down-Regulation of miR-23a-3p Mediates Irradiation-Induced Neuronal Apoptosis. Int J Mol Sci. 2020;21(10):E3695. 2020 May 24. PMID: 32456284.
Abulwerdi G, Stoica BA, Loane DJ, Faden AI. Putative mGluR4 Positive Allosteric Modulators Activate Gi-Independent Anti-Inflammatory Mechanisms in Microglia. Neurochem Int. 2020 May 23:104770. doi: 10.1016/j.neuint.2020.104770. Online ahead of print. PMID: 32454165.
Henry RJ, Meadows VE, Stoica BA, Faden A, Loane DJ. Longitudinal assessment of sensorimotor function following controlled cortical impact in mice: comparison of beamwalk, rotarod and automated gait analysis tests. J Neurotrauma. 2020 Jun 2. doi: 10.1089/neu.2020.7139. Online ahead of print. PMID: 32484024.
Sarkar C, Jones JW, Hegdekar N, Thayer JA, Kumar A, Faden AI, Kane MA, Lipinski MM. PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. Autophagy. 2020 Mar;16(3):466-485. doi: 10.1080/15548627.2019.1628538. Epub 2019 Jun 25.
Li Y, Ritzel RM, Lei Z, Cao T, He J, Faden AI, Wu J. Sexual dimorphism in neurological function after SCI is associated with disrupted neuroinflammation in both injured spinal cord and brain. Brain Behav Immun. 2021 Dec 23; 101:1-22. PMID: 34954073
Li Y, Cao T, Ritzel RM, He J, Faden AI, Wu J. Dementia, Depression, and Associated Brain Inflammatory Mechanisms after Spinal Cord Injury. Cells. 2020 Jun 8;9(6):1420. doi: 10.3390/cells9061420. PMID: 32521597
Sabirzhanov B, Makarevich O, Barrett JP, Jackson IL, Glaser EP, Faden AI, Stoica BA. Irradiation-Induced Upregulation of miR-711 Inhibits DNA Repair and Promotes Neurodegeneration Pathways. Int J Mol Sci. 2020 Jul 23;21(15):5239. doi: 10.3390/ijms21155239. PMID: 32718090
Makarevich O, Sabirzhanov B, Aubrecht TG, Glaser EP, Polster BM, Henry RJ, FADEN AI, Stoica BA. Mithramycin selectively attenuates DNA-damage-induced neuronal cell death. Cell Death Dis. 2020 Jul 27;11(7):587. doi: 10.1038/s41419-020-02774-6. PMID: 32719328
Li Y, Ritzel RM, Khan N, Cao T, He J, Lei Z, Matyas JJ, Sabirzhanov B, Liu S, Li H, Stoica BA, Loane DJ, Faden AI, Wu J. Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice. Theranostics. 2020 Sep 14;10(25):11376-11403. doi: 10.7150/thno.49199. eCollection 2020. PMID: 33052221
Ritzel RM, He J, Li Y, Cao T, Khan N, Shim B, Sabirzhanov B, Aubrecht T, Stoica BA, Faden AI, Wu LJ, Wu J. Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury. Glia. 2021 Mar;69(3):746-764. doi: 10.1002/glia.23926. Epub 2020 Oct 22. PMID: 33090575
Khan NZ, Cao T, He J, Ritzel RM, Li Y, Henry RJ, Colson C, Stoica BA, Faden AI, Wu J. Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential. Brain Behav Immun. 2021 Feb;92:165-183. doi: 10.1016/j.bbi.2020.12.007. Epub 2020 Dec 9. PMID: 33307173
Hanscom M, Loane DJ, Aubretch T, Leser J, Molesworth K, Hedgekar N, Ritzel RM, Abulwerdi G, Shea-Donohue T, Faden AI. Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits. J Neuroinflammation. 2021 Jan 18;18(1):24. doi: 10.1186/s12974-020-02067-x. PMID: 33461596
Faden AI, Barrett JP, Stoica BA, Henry RJ. Bidirectional Brain-Systemic Interactions and Outcomes After TBI. Trends Neurosci. 2021 Jan 22:S0166-2236(21)00002-3. doi: 10.1016/j.tins.2020.12.004. Online ahead of print. PMID: 33495023
Hanscom M, Loane DJ, Aubretch T, Leser J, Molesworth K, Hedgekar N, Ritzel RM, Abulwerdi G, Shea-Donohue T, Faden AI. Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits. J Neuroinflammation. 2021;18(1):24. PMID: 33461596.
Ritzel RM, Li Y, Lei Z, Carter J, He J, Choi HM, Khan N, Li H, Allen S, Lipinski MM, Faden AI, Wu J. Functional and transcriptional profiling of microglial activation during the chronic phase of TBI identifies an age-related driver of poor outcome in old mice. Geroscience. 2022;44(3):1407-1440. PMID: 35451674.
Li Y, Ritzel RM, Lei Z, Cao T, He J, Faden AI, Wu J. Sexual dimorphism in neurological function after SCI is associated with disrupted neuroinflammation in both injured spinal cord and brain. Brain Behav Immun. 2022;101:1-22. PMID: 34954073.
Ritzel RM, Li Y, Jiao Y, Lei Z, Doran SJ, He J, Shahror RA, Henry RJ, Khan R, Tan C, Liu S, Stoica BA, Faden AI, Szeto G, Loane DJ, Wu J. Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegeneration. Sci Adv. 2023 Mar 10;9(10). PMID: 36888713.
Lei Z, Krishnamachary B, Ritzel RM, Khan NZ, Li Y, Li H, Brunner K, Faden AI, Wu J. Age-related changes in plasma extracellular vesicles influence neuroinflammation in the brain and neurological outcome after traumatic spinal cord injury. Res Sq [Preprint]. 2023 Apr 17:rs.3.rs-2821858. PMID: 37131758.