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Vascular Imaging Core
DepartmentsDepartment of SurgeryDivisionsDivision of Vascular SurgeryVascular Imaging CoreCore Lab StudiesACCOF FAMILY

ACCOF FAMILY

Asymptomatic Carotid Stenosis: Cognitive Function and Plaque Correlates (ACCOF-1)

Study demonstrated that asymptomatic carotid stenosis impairs cognitive function and developed a novel 3D ultrasound technology/technique to evaluate carotid plaque morphology (geometry and tissue-composition). Transcranial Doppler was used to measure microembolization rates to the middle cerebral artery. TCD was also used with breath holding to quantify cerebrovascular reactivity.

The Core Lab’s role was to conduct, compile, store, and analyze all the above imaging data.

  • Funding: VA Clinical Sciences Research and Development Department (CSR&D)
  • PI: Brajesh K Lal, MD
  • Coordinator: Laila Anthony
  • VIC Staff: John Yokemick

     


ASYMPTOMATIC CAROTID STENOSIS: COGNITIVE FUNCTION AND PLAQUE CORRELATES – 2 (ACCOF-2)

ACCOF family

A clinical study looking at patients with >70%, high-grade stenosis. Assessment of cognitive and physical functions at baseline then reassessment after revascularization.

The Core Lab’s role in this study is to perform and analyze 2D-DUS and transcranial Doppler studies in house and preserve records from the trial. Additionally, we distribute radiologic imaging to specific sites for associated research projects.

  • Funding: VA Clinical Sciences Research and Development Department (CSR&D)
  • PI: Brajesh K Lal, MD
  • Sub-I: Sarasijhaa Desikan MD, Vicki Gray MPT PhD, Moira Dux PhD, Jigar Patel MD, and John D. Sorkin MD PhD
  • Coordinators: Emily Redding
  • VIC Staff: John Yokemick, Brian Caraballo, Janice Martinez-Delcid, Matt Chrencik

 

 

 

ASYMPTOMATIC CAROTID STENOSIS: COGNITIVE FUNCTION AND PLAQUE CORRELATES - Exercise Intervention (ACCOF-EX)

A clinical study looking at patients with >50%, moderate asymptomatic carotid artery stenosis. Assessment of cognitive and physical functions after 12-week aerobic exercise and balance training program.

The Core Lab’s role in this study is to perform and analyze 2D-DUS and transcranial Doppler studies in house and preserve records from the trial. Additionally, we distribute radiologic imaging to specific sites for associated research projects.

  • Funding: Department of Surgery
  • PI: Sarasijhaa Desikan MD
  • Mentors & Sub-Is: Brajesh K Lal MD, Vicki Gray MPT PhD
  • Coordinator: Emily Redding
  • VIC Staff: John Yokemick

 

 

Dental Carotid Cognitive Study (DCCS): Treatment of Periodontitis to Prevent Dementia in Older Adults with Asymptomatic Carotid Artery Stenosis and Mild Cognitive Impairment

A clinical study examining the effects of intensive therapy for periodontitis on cognition, inflammation and brain function in high-risk people with asymptomatic carotid artery stenosis and mild cognitive impairment. Results could highlight periodontal disease as a readily modifiable risk factor for dementia.

The Core Lab’s role in this study is to perform and analyze 2D-DUS and transcranial Doppler studies in house and preserve records from the trial. Additionally, we distribute radiologic imaging to specific sites for associated research projects.

  • Funding: National Institute on Aging- NIH
  • PI: Brajesh Lal, MD
  • Sub-I: Andrew Goldberg MD, Thomas Oates DMD PhD, Brock Beamer MD, Laurence Magder PhD, Shari Waldstein PhD, Michael Terrin MD MPH, John Sorkin MD PhD
  • Coordinator: Dawn Barth, RN
  • VIC Staff: John Yokemick, Brian Caraballo