IGS Researchers Use Multiomics to Investigate Microbial Genomics & Infectious Diseases
The faculty who investigate microbial and multicellular pathogens use multiomics to better understand how organisms and populations respond to selective pressures and external stimuli, such as drugs, vaccines, and the presence of other organisms.
They research host-microbe interactions, characterizing molecular interactions between them, to identify determinants of pathogenesis. Their research identifies disease phenotypes, novel approaches to control chronic and invasive infections, and markers of vaccine efficacy.
These studies employ a variety of state-of-the-art techniques, such as epi-transcriptomics, multiomics sequencing in single nuclei, spatial transcriptomics, dual-species transcriptomics, and single cell proteomics as well as immuno- and phospho-proteomics, using molecular assays, and various infection models.