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Translational Laboratory


The University of Maryland Greenebaum Comprehensive Cancer Center Translational Laboratory Shared Service (TLSS) offers pre-clinical and clinical
experimental support to basic researchers and physicians in the UMGCCC community. We work in areas across the entire spectrum: cell biology, in vitro, in vivo and human trials.


Translational-Lab01In Vitro Assays

  • Mycoplasma testing
  • Clonogenic Survival Assays
  • IC50 generation
  • Cell cycle (propidium iodide)
  • Viability (trypan blue exclusion)
  • Apoptosis
  • Potentiation/Synergy
  • ROS
  • Western Analysis
  • Angiogenesis

Image of MiceIn Vivo Assays

  • IACUC approved umbrella protocol
  • Tolerability
  • Tumor Growth
  • Patient Derived Xenograft Models
  • Pharmacokinetics: generation of plasma
  • Efficacy (flank models)
  • Efficacy (orthotopic models)
  • Pharmacodynamic Endpoints
  • Imaging of cells with Xenogen System

‌Pharmacodynamic (PD) Endpoints

  • in-patient samples, tumor or surrogate tissues, preclinical samples
  • Endpoint dependent on target (e.g., ELISA, flow cytometry, Western, unique assay)

CRISPR Services:

  • Knock Down and Single Nucleotide Polymorphism

Visit the CRISPR Services Website


  • Access to >120+ human/murine cell lines
  • Luciferase-expressing breast, leukemia, ovarian and prostate cancer cell lines
  • IACUC approved umbrella protocol
  • Access/Knowledge in Using Xenogen/IVIS Imaging Mice
  • Primary Derived Xenograft Models
    • Breast
    • Head and Neck (under development)
    • Leukemia (under development)
    • Ovarian (under development)
    • Pancreatic (under development)
Access to IRB approved protocol for tissue acquisition

Clinical Trial Support:

We isolate:

  • Plasma
  • Serum
  • Whole Blood (isolation of PBMC, DNA, RNA, protein)
  • Bone Marrow (isolation of marrow cells)
  • Staining of isolated lymphocyte cells
  • Coordination with Flow Cytometry Core for analysis
  • Exosomes and ct DNA

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Antonino Passaniti

Antonino Passaniti, PhD

Translational Laboratory Staff

Katharina Richard, PhD
Brandon Carter-Cooper, MS
Xinrong Ma, MD
Kayla Tighe, BS
Andrea Casildo, BS


Bressler Research Building
Room 7-010
655 West Baltimore Street
Baltimore, MD 21201


Monday through Friday
7:00am - 5:00pm


Office: 410-706-2171

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