The Medicinal Chemistry (MC) section conducts innovative, multidisciplinary and collaborative research to discover and develop new drugs for improving human health. They are dedicated to hit-to-lead medicinal chemistry and lead optimization. The medicinal chemists within the CBT work together with the Computer Aided Drug Design (CADD) center and other medicinal chemists within the School of Pharmacy (SOP). Thus, the efficient design of inhibitors, searches of structurally related compounds (SAR by catalogue), and virtual screening capabilities are done via CADD in conjunction with syntheses efforts from the MC section.
Capabilities
Instrumentation
- 400 MHz Bruker Ascend walk-up NMR
- LC/MS and LC/MS/MS
- Milestone START microwave synthesizer
- Fully automated HPLC systems (analytical and preparative)
- CombiFlash Rf-200 automated Flash Chromatography System
- Autopol III – dual wavelength automatic polarimeter
- Perkin Elmer 1600 FTIR Infrared spectrometer
- High-resolution mass spectrophotometer (MS/HRMS)
Services
- Hit-to-lead medicinal chemistry
- Synthesis of research and proprietary compounds
- Rational design and synthesis of new molecules
- Lead optimization employing SAR
- Medicinal chemistry strategies to achieve superior ADMET properties