The CBT is structured into seven Sections whose leaders work with PIs, postdoctoral fellows, and students to address complex research goals by providing expertise and state-of-the-art resources.

Please visit each section page to learn more about their capabilities and instrumentation.

 

Protein Engineering & Biophysics (PEB)

Section Leader: Jonathan Fay, PhD

Provides expertise and assistance in producing purified proteins for investigators, including those needed for advanced uses in other CBT sections (i.e. Structural Biology (SB) and Target Validation & Screening (TVS)).

 

Structural Biology (SB)

Section Leader: Kristen Varney, PhD

CryoEM, NMR, and X-ray crystallography provide users a suite of complementary structural biology approaches to determine three-dimensional structures and elucidate dynamic properties of proteins, protein complexes, and other macromolecules. 

 

Target Validation & Screening (TVS)

Section Leader: Gerald Wilson, PhD

Cell and molecular biology techniques are used to identify therapeutic targets and develop assays for chemical perturbagens as a step towards generating new drugs and therapies.

 

 

Medicinal Chemistry (MC)

Section Leader: Vincent Njar, PhD

Discovering and developing new drugs for improving human health.

 

 

Computer-Aided Drug Design (CADD)

Section Leader: Alex MacKerell, PhD

The CBT works with the UMB School of Pharmacy to provide computational approaches to speed drug discovery and design. 

 

 

In Vivo Biology & Drug Testing (IVBDT)

Section Leader: Rena Lapidus, PhD

The CBT works with the UMB Translational Laboratory Shared Resource (TLSR) for in vivo pre-clinical evaluation of chemical probes and lead compounds from drug discovery efforts, as well as diagnostics.

 

 

Genomics & Bioinformatics (GB)

Section Leader: Scott Devine, PhD

The CBT works directly with the Institute for Genome Sciences (IGS) to generate high quality genomic data and genome annotation/analysis.