The Center for Precision Disease Modeling at the University of Maryland School of Medicine (CPDM-UMSOM) offers a variety of services aimed to propel translation of disease-associated genetic variants into targeted therapeutics and to benefit the biomedical community. These include a resource the Center’s carefully curated and well-documented biorepository of precision animal/cell disease models including fly (Drosophila melanogaster), zebrafish (Danio rerio) and human induced pluripotent stem (iPS) cell-derived models, as well as unique services that range from design to precision disease mechanistic and targeted therapeutics projects. Collaboration and communication between the different Center Section (Service Section, Bioinformatic Section, Disease Modeling Unit and Preclinical Section) will be critical to the Center’s success. The Coordination Section has been tasked with providing oversight and support, with keeping projects on time and on task, setting Center priorities, and with coordinating communication and maximizing the synergy between the different Center Sections. They will develop and implement strategies to maximize interaction with the biomedical community and engage its members to participate in Center activities. And, they will actively seek out opportunities for collaboration with other initiatives in order to provide the best Services and tools possible. The Coordination Section will further track and report metrics of CPDM success in delivering services to the biomedical community and monitor the impact of Center activities on the biomedical field.
Roles of the Coordination Section and its interaction with the other center sections
The Coordination Section at CPDM-UMSOM integrates the Center’s scientific and administrative components. The Coordination Section is highly significant for the following specific duties that it performs:
- Ensuring Service as the Top Priority: The Coordination Section ensures that the number one priority of the Center is to provide services for the biomedical community that aid the translation of genetic variants in clinically meaningful ways. All Center activities are structured with this in mind.
- Maintain Synergistic Interactions: The Coordination Section is the key to maintain synergistic interactions of the Disease Modeling Unit, Preclinical Section, Bioinformatics Section, and Service Section.
- Become an Effective Portal: The Coordination Section is the portal between all Center Sections and the Center Steering Committee and the External Advisory Broad. It ensures that Center activities and progress are regularly reported to the governing bodies and their decisions and recommendations are effectively followed.
- Community Outreach: The Coordination Section is also responsible for reaching out to the biomedical community to advise on the services provided by CPDM.
The CPDM’s pipeline projects will run across multiple sections, therefore communication and synergizing efforts will be essential for the Center’s success. The Coordination Section will develop strategies to optimize the interaction between the different sections (depicted as arrows in the figure). In addition to within Center cross-talk, the Core will coordinate active interaction with the clinical and research biomedical community as well as other initiatives. Finally, the Coordination Core will be the main point of contact for the Steering Committee, NIH Program Staff and the External Advisory Board.