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Center for Precision Disease Modeling
DepartmentsDepartment of MedicineDivisionsDivision of Endocrinology, Diabetes and NutritionResearchCenter for Precision Disease ModelingCPDM Catalog

CPDM Catalog

Please email us at CPDM@som.umaryland.edu for more information

Fruit Fly (Drosophila Melanogaster) Models

Disease Genotype Note
Heart Disease Hand-GFP Best GFP marker for visualizing the fly heart
Heart Disease Hand-Gal4 Heart-specific Gal4 driver 
Heart Disease 4xHand-Gal4 Strongest heart-specific Gal4 driver 
Heart Disease   Hand-GFP, 4xHand-Gal4 Strongest heart-specific Gal4 driver & heart marker 
Heart Disease  UAS-WDR5-wt   Wildtype human WDR5 gene 
Heart Disease  UAS-WDR5-K7Q   Congenital Heart Disease variant for WDR5 
Kidney Diseases  MHC-ANF-RFP  Fly nephrocyte functional marker 
Kidney Diseases  MHC-ANF-RFP, Dot-Gal4  Nephrocyte-specific Gal4 driver & nephrocyte functional marker 
Kidney Diseases  UAS-COQ2-wt   Wildtype human COQ2 
Kidney Diseases   UAS-COQ2-S146N  Nephrotic Syndrome variant for COQ2 
Kidney Diseases    UAS-CD2AP-wt  Wildtype human CD2AP 
Kidney Diseases   UAS-CD2AP-K301M  Nephrotic Syndrome variant for CD2AP 
Kidney Diseases   UAS-NUP160-wt   Wildtype human NUP160 
Kidney Diseases   UAS-NUP160-E803K  Nephrotic Syndrome variant for NUP160
Kidney Diseases   UAS- NUP160-R1173X  Nephrotic Syndrome variant for NUP160
Blood Diseases Hml-Gal4, UAS-GFP Blood specific Gal4 driver plus GFP 
Muscle Disease Mef2-Gal4, UAS-RFP Muscle-specific Gal4 driver plus RFP 
Neurological Diseases  Elav-Gal4, UAS-GFP  Neuronal Gal4 driver plus GFP 
Metabolic Diseases  FB-Gal4, UAS-GFP  Fat body-specific Gal4 driver & GFP 
Metabolic Diseases  Tub-Gal4  Ubiquitous Gal4 driver 

Zebrafish (Danio rerio) Models

Disease Genotype Note
Heart Disease cmlc2:GFP Best GFP marker for visualizing the zebrafish heart
Heart Disease rttn -/- Model of dilated cardiomyopathy
Heart Disease VU177 Model of Conotruncal defects
Vascular Disease fli:egfp Best GFP marker for visualizing the zebrafish vasculature
Vascular Disease vbg Model of hemorrhagic telangiectasia type 2
Signaling Reporter OTM:dGFP Reports wnt activity
Signaling Reporter dusp6:dGFP Reports FGF activity
Signaling Reporter Her4:RFP Reports Notch activity 

Human Induced Pluripotent Stem Cells (iPSC)

Disease iPSC name Reprogramming method Source Sex of patient
Epilepsy DEPC-29 Sendai virus   F
Epilepsy DEPI-22 Sendai virus   F
Tuberous sclerosis complex epilepsy TSP20-1 Sendai virus fibroblast F
Tuberous sclerosis complex epilepsy TSP 16-8 episomal vector fibroblast M
Dilated cardiomyopathy LViP-1 episomal vector Left ventricular cardiac fibroblast M
Dilated cardiomyopathy LViP-3 episomal vector Left ventricular cardiac fibroblast M
Long QT type 1 LCL-4 episomal vector EBV-immortalized Lymphoblastoid cell line  
Long QT type 1 LCL-8 episomal vector EBV-immortalized Lymphoblastoid cell line