Resource & Service
Our Mission and Service:
The Center for Precision Disease Modeling offers a carefully curated and well-documented biorepository for Drosophila melanogaster (fly), Danio rerio (zebrafish) and human-induced pluripotent stem cells (hiPSCs). The Resource and Service is your point of contact for any inquiries or services. Our highly experienced team of researchers is specialized in precision disease modeling using fly, zebrafish and hiPSC model systems as well as comparative bioinformatics analysis and ontology. We are here to help you apply these approaches to answer your research questions on feasibility, functional analysis, disease mechanisms and/or drug discovery. Contact us for more information (CPDM@som.umaryland.edu), search our catalog or submit your variants of interest.
Handling variant submissions: CPDM offers an evaluation of the feasibility of modeling the genetic disease variant in one or more of our platforms. We will provide a report with our recommendations (free-of-charge).
Bio- and Data Repository: The biorepository safeguards its carefully curated samples, their quality, and documentation.
Community relations: The Center organizes seminars and an annual symposium as a platform to disseminate research. We also offer internship opportunities (email us if you are interested - CPDM@som.umaryland.edu).
Interaction with the other center sections
Service Section Management:
First and foremost, the Resource and Service Section interacts with the biomedical community including customer services, community relations, and engagement activities and is the point of contact between all Center Sections and the community. Second, we work closely with the Bioinformatic Section to develop and maintain the Center website, and they support us with developing metrics to measure how successful we are in serving the community and meeting their needs. Third, we work closely with the Disease Modeling Unit in the acquisition, validation, and distribution of precision disease models. Further, we will communicate regularly with safety regulatory oversight programs to ensure we adhere to the latest standards, laws, and regulations. We will actively seek out other NIH-supported repositories to engage in collaborative endeavors. For oversight, we will communicate directly with the Steering Committee, which includes the NIH Project Scientist and Program Officer as voting members, and with the Coordination Section. Through the latter, we will also receive feedback and recommendations from the External Advisory Board.
Delivery of Resource and Services:
The information flow and interaction related to the services provided by the Center are depicted by blue (level 1), green (level 2), yellow (level 3), red (level 4) and grey arrows in the figure. The Service Section is directly involved in the colored arrows. We process initials requests, work with the Bioinformatic Core to generate the initial feasibility report, and mediate communications between the different Center Sections and the requestor, including the delivery of project proposals with quotes and research reports.