At the intersection of therapeutic concepts and technical innovations, we employ interdisciplinary approaches to advance minimally invasive interventions and improve clinical outcomes.

Therapeutic Concepts

Our efforts primarily focus on regenerative medicine and oncology. We leverage recent breakthroughs in molecular targeting and prioritize biological therapeutic agents such as cells, vesicles, viruses, proteins, nanoparticles, and more. We have recently embarked on CRISPR-based technologies for image-guided genome editing of the brain and other pathologies. The increased penetration of therapeutic agents to the pathologies increases their therapeutic effects and minimizes adverse events. These agents hold immense potential due to their high efficacy and minor adverse effects, but their delivery to the central nervous system (CNS) and other tissues presents significant challenges.

Technical Developments

Technical developments focus on three directions, which are essential for full implementation of image-guided neurointerventions.

Labeling and Visualization of Agents

Therapeutic agent labeling protocols are meticulously tailored based on their chemical composition, disease type, species, and specific requirements like spatial resolution, sensitivity, and follow-up duration. Our primary tools are clinically applicable techniques such as magnetic labeling with iron oxide nanoparticles and 89Zr-based radiolabeling. Additionally, bioluminescence with advanced reporter genes provides unparalleled insights into cellular dynamics, while high-resolution intravital two-photon microscopy enables the examination of brain function at the subcellular level. Therefore, we cover the entire spectrum of in vivo imaging from sub-cellular resolution of two-photon microscopy to clinically applicable PET scanning.

Device Development

Progress in imaging neurointerventions necessitates the creation of specialized devices such as catheters, needles, coils, and even scanners. These devices are custom designed to meet the unique demands of CNS applications, seamlessly integrating into the workflow of interventional procedures. Ensuring these devices' safe and precise application for advanced PET- and MRI-guided interventions is paramount. We are involved on a project on robotized endovascular catheter development

Image Processing

Effective image-guided neurointerventions require robust, real-time image processing algorithms to deliver comprehensive procedural feedback. We are exploring artificial intelligence-based and other solutions that enhance efficiency and reliability to meet these demands.