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- Frank hypointensity (i.e. dark hue) on CT of the brain, particularly if involving greater than one-third of the middle cerebral artery (MCA) territory, is a contraindication to treating acute ischemic stroke with tPA.
- Early signs of infarct on brain CT, regardless of extent, are NOT contraindications to treatment.
References
- Latchaw et al. Recommendations for imaging acute ischemic stroke: A scientific statement from the American Heart Association. Stroke 2009;40:3646-78.