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Oseltamivir (Tamiflu)
- Has low protein binding and does not inhibit CYP450 (resulting in a low incidence of drug interactions)
- Requires dosage adjustment with creatinine clearance of < 30 ml/min
- Does not require dosage adjustment in patients with liver failure or the elderly
- Most common adverse effects are nausea and vomiting
- Serious effects include anaphylaxis and skin reactions. Neuropsychiatric effects reported include hallucinations, delerium and abnormal behavior
- It may be administered to infants and children due to the high potential morbidity associated with influenza
For complete indications and dosing: www.cdc.gov/h1n1flu/recommendations.htm
References
www.cdc.gov/h1n1flu/recommendations.htm
www.cdc.gov/flu/professionals/antivirals/side-effects.htm