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This large UK and US study looked at the addition of high dose cryoprecipitate to mass transfusion protocols and found: “Among patients with trauma and bleeding who required activation of a major hemorrhage protocol, the addition of early and empirical high-dose cryoprecipitate to standard care did not improve all cause 28-day mortality.”
References
Davenport RCurry NFox EE, et al. Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial. JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.21019