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Propofol Infusion Syndrome
- Many of us are now using propofol for sedation in our critically ill patients
- Although a great drug, it is important to be aware of "propofol infusion syndrome" (PIS)
- Risk factors for PIS include young age, severe CNS or pulmonary illness, and exogenous catecholamine administration
- Clinical features include: unexplained metabolic acidosis, rhabdomyolysis, hyperlipidemia, hepatomegaly, and cardiovascular instability
- Pearl: It is reported that the development of coved ST elevations in V1-V3 (similar to Brugada syndrome) may be the first sign of cardiac instability with PIS
References
Kam PCA, Cardone D. Propofol infusion syndrome. Anaesthesia 2007;62:690-701.