Search
Sepsis-3
- After nearly 2 decades, the definitions for sepsis and septic shock have been updated.
- Key findings from the Task Force convened by SCCM and ESICM include:
- Sepsis
- Definition: life-threatening organ dysfunction due to a dysregulated host response to infection
- ICU patients: organ dysfunction is defined as an increase of 2 points or more in the Sequential Organ Failure Assessment (SOFA) score
- ED patients: 2 or more of the following new qSOFA (quickSOFA) score may identify patients with increased mortality
- SBP less than or equal to 100 mm Hg
- RR greater than or equal to 22
- Altered mental status
- Septic Shock
- Definition: a subset of patients with sepsis and profound circulatory, cellular, and metabolic abnormalities
- Clinical Criteria:
- Persistent hypotension requiring vasopressors to maintain MAP greater than or equal to 65 mm Hg despite adequate volume resuscitation
- Lactate greater than or equal to 2 mmol/L
- The term "severe sepsis" is no longer used
- Sepsis
References
Singer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315:801-10.