UMEM Educational Pearls

Keywords

Category

Author

Title: Headaches and Pregnancy

Category: Obstetrics & Gynecology

Keywords: Migraines, Pregnancy (PubMed Search)

Posted: 1/27/2008 by Michael Bond, MD (Updated: 3/3/2026)

Migraines and Pregnancy

Typically headache frequency will increase during the first 2 to 3 months of pregnancy
70% of women report significant improvement in headaches during their second and third trimester.
Most migraine medication should NOT be given to pregnant woman. Verify prior to prescribing.
- Class X/D drugs include
  - Cafergot (ergotamine)
  - Depakote
  - Dihydroergotamine (DHE)
- Class C drugs include
  - Imitrex
  - Zomig
  - Midrin
  - Relapex
Some headache centers will prophalax pregnant woman with Vitamin B2 and Magnesium.