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SSRI Toxicity
Things to watch for in patients that are taking SSRI:
- Therapeutic administration usually safe
- Hyponatremia is a common adverse effect (ADH secretion regulated by serotonin)
- Serotonin Syndrome is a possibilty in combination with other serotnergic drugs
- One SSRI is more problematic than the rest => Citalopram and Escitalopram
- The only SSRI that can cause QT prolongation (even 24hrs after OD) and can cause seizures
- This is the only SSRI with significant toxicity and unfortunately is the most commonly Rx by psych