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Aortic valve (AV) stenosis associated with gastrointestinal angiodysplasia
Proteolysis of Von Willebrand (type 2A) as it passes through the stenotic valve is one culprit of bleeding
Hemostatic abnormalities e.g. GI bleed are often corrected after AV replacement
Valve replacement is only recommended for cardiac symptoms
References
Vincentelli A, Susen S, et al. Acquired von Willebrand Syndrome in Aortic Stenosis. N Engl J Med 2003; 349:343-349