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- Sulfonyurea overdose is associated with hypoglycemia, which may be delayed and prolonged.
- Treatment with dextrose results in hyperglycemia, which potentiates insulin release from the pancreas, resulting in recurrent hypoglycemia.
- Octreotide mimics somatostatin, which suppresses the secretion of glucagon and insulin, among others.
- Octreotide binds with somatostatin receptors, closing calcium channels, preventing the influx of calcium and subsequent insulin release.
- The dose is 100 mcg SUBCUTANEOUSLY, repeated every 8 hours as needed.
References
Dougherty PP, Klein-Schwartz W. J. Med Toxicol 2010;6:199-206.