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Classic Kawasaki is diagnosed by fever for greater than 5 days plus 4 out of 5 classic signs.
- Mnemonic: “CRASH and burn”
- Conjunctivitis (bilateral and nonexudative)
- Rash (polymorphous, ie can look like anything)
- Adenopathy (cervical, usually greater than 1.5cm and usually unilateral)
- Strawberry tongue or other oral changes (lip swelling/fissuring/erythema/bleeding, oropharyngeal hyperemia)
- Hands and feet (induration and erythema, desquamation is a late sign)
- Burn = fever lasting for >5 days
But what about an 8 month-old with 6 days of fever plus nonexudative conjunctivitis, unilateral cervical adenopathy and a diffuse maculopapular rash? Send some labs!
Incomplete Kawasaki is defined as fever for >5 days with 2 or more of the classic findings plus elevated ESR (>40mm/hr) and CRP (>3.0mg/dL). It is most common in infants under 12 months of age.
Disposition for the 8 month-old?
- If ESR and CRP are not elevated, discharge to home with f/u in 24 hours to re-evaluate symptoms and for repeat labs if fever persists.
- If ESR and CRP are elevated, the child needs an echo to evaluate for coronary artery aneurysms.
If the echo is normal, follow up in 24-48 hours and will need a repeat echo if fever persists.
TREAT kids with IVIG and aspirin (which generally means admission) if echo is positive, or with normal echo and the presence of 3 or more supplemental criteria:
- Anemia for age
- Elevated ALT
- Albumin<3.0mg/dL,
- Sterile Pyuria (>10 WBC/hpf)
- Platelets >450K after 7 days
- WBC >15,000