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Thrombolytic Therapy for Pulmonary Embolism
Current, FDA-approved thrombolytic therapy for PE:
- tPA 100 mg over two hours-infusion
- Heparin drip should be turned off during tPA infusion and turned back on ONLY after PTT has fallen to 2 X normal
- Other drugs are being used-like Tenecteplase (TNKase), but strictly speaking, not FDA approved for thrombolysis of PE
- Most studies to date do not show that catheter-based delivery of lytics is safer than systemically administered lytics