Modulating How Injured Tissue is Sensed and Repaired
Metabolic glycoengineering (MGE) is a biochemical strategy in which therapeutic cells are supplied with engineered sugar building blocks, enabling the glycans on their surface to be rewritten in predictable ways and thereby modulating how injured tissue is sensed and repaired.
In our laboratory, MGE is applied to human neural stem cells and adipose-derived stem cells to enhance adhesion, survival, and pro-repair signaling. As a result, enhanced neuronal differentiation following brain injury, more rapid and stable Schwann-like differentiation, and ultimately stronger support for axonal growth and neural circuit recovery are achieved.