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2025

2025 Publications

Robert H. Christenson, PhD

  1. Supples MW, Dameron AG, Powell S, Snavely AC, Ashburn NP, Allen BR, Christenson RH, Wilkerson RG, Mumma BE, Madsen TE, Mahler SA. The HET (history, electrocardiogram, and troponin) score has low efficacy and negative predictive value in a multisite U.S. cohort study. Am J Emerg Med. 2025 Mar;89:151-158. doi: 10.1016/j.ajem.2024.12.012. Epub 2024 Dec 15. PMID: 39729682.
  2. Griffith BP, Grazioli A, Singh AK, Tully A, Galindo J, Saharia KK, Shah A, Strauss ER, Odonkor PN, Williams B, Silverman HJ, Burke A, Drachenberg CB, Wells CL, Dickfeld T, Hong SN, Hicks AJ 3rd, Ananthram M, Gupta A, Christenson RH, Tamburro L, Zhang T, Hershfeld A, Lewis B, Feller ED, Kuravi K, Sorrells L, Morgand E, Mezine F, Goutaudier V, Rothblatt M, Lau CL, Taylor B, Perrin S, Loupy A, Ayares D, Mohiuddin MM. Transplantation of a genetically modified porcine heart into a live human. Nat Med. 2025 Feb;31(2):589-598. doi: 10.1038/s41591-024-03429-1. Epub 2025 Jan 8. PMID: 39779924.
  3. Daniels LB, Ajongwen P, Christenson RH, Clark CL, Diercks DB, Fermann GJ, Mace SE, Mahler SA, Pang PS, Rafique Z, Runyon MS, Tauras J, deFilippi CR. Clinical Performance of an N-Terminal Pro-B-Type Natriuretic Peptide Assay in Acute Heart Failure Diagnosis. J Appl Lab Med. 2025 Mar 3;10(2):325-338. doi: 10.1093/jalm/jfae107. PMID: 39495056.
  4. Bima P, Lopez-Ayala P, Koechlin L, Morello F, Boeddinghaus J, Dimitrova M, Spagnuolo CC, Kaplan E, Nestelberger T, Glaeser J, Wildi K, du Fay de Lavallaz J, Morawiec B, Miro O, Martínez-Nadal G, Martin-Sanchez FJ, Christ M, Slankamenac K, Labarile G, Lindahl B, Giannitsis E, Lupia E, Mueller C; APACE and TRAPID-AMI Investigators. Derivation and Validation of ESC-0/1-h Algorithm for High-Sensitivity Troponin T and I in Cancer Patients. JACC Adv. 2025 Jun;4(6 Pt 1):101821. doi: 10.1016/j.jacadv.2025.101821. Epub 2025 May 22. PMID: 40408798; PMCID: PMC12152628.
  5. Caton ER, Pan Y, Kiser KM, Haddaway CR, Bryden WA, McLoughlin M, Mirski MA, Christenson RH, Sevilla CC, Feng S, Chen S, Chen D. Rapid sepsis diagnosis with protease activity measurement. medRxiv [Preprint]. 2025 Jul 15:2025.07.14.25331514. doi: 10.1101/2025.07.14.25331514. PMID: 40791693; PMCID: PMC12338904.
  6. Schwalb ME, McEvoy JW, Navas-Acien A, Wallace AS, Rooney MR, Selvin E, Christenson RH, Jones MR. Tobacco Exposure and Markers of Myocardial Stress and Damage Among US Adults. Am J Cardiol. 2025 May 15;243:19-21. doi: 10.1016/j.amjcard.2025.01.028. Epub 2025 Jan 31. PMID: 39894331.
  7. Christenson RH, Alahapperuma D, Allen BR, Guidi JL, Headden G, Peacock WF, Winden N, Januzzi JL Jr. Analytical Characterization and Validation of a Novel Automated Amino-Terminal proB-Type Natriuretic Peptide Assay. J Appl Lab Med. 2025 May 2;10(3):659-670. doi: 10.1093/jalm/jfaf012. PMID: 40071769.
  8. Guidi JL, Allen BR, Headden G, Winden N, Alahapperuma D, Christenson RH, Peacock WF, Januzzi JL. A novel NT-proBNP assay for heart failure diagnosis: A prospective, multicenter clinical trial. Clin Chim Acta. 2025 May 15;572:120249. doi: 10.1016/j.cca.2025.120249. Epub 2025 Mar 17. PMID: 40107595.
  9. Wu AHB, Levy JH, Peacock WF, Rimawi R, Sanchez Luna M, Farnsworth C, Stiegler H, Christenson RH. Handling Hemolytic Blood Samples from High-Risk Clinical Areas: A Call to Action. J Appl Lab Med. 2025 Sep 3;10(5):1347-1361. doi: 10.1093/jalm/jfaf082. PMID: 40709795.
  10. Wilkerson RG, Ashburn NP, Snavely AC, Allen BR, Christenson RH, Weaver M, Zhang X, Madsen TE, Mumma BE, Supples MW, Mahler SA. Performance of High-Sensitivity Troponin T Risk Stratification Strategies for 90-day Cardiac Death or Myocardial Infarction. Crit Pathw Cardiol. 2025 Sep 1;24(3):e0397. doi: 10.1097/HPC.0000000000000397. Epub 2025 Jul 16. PMID: 40668737.
  11. Shuter J, Davis OA, deFilippi C, Christenson RH, Li L, Potts W, Himelhoch S. Nicotine Metabolite Ratio in People with HIV Who Smoke Cigarettes Receiving Pharmacologic and Behavioral Cessation Therapy. Cancer Prev Res (Phila). 2025 Mar 3;18(3):111-115. doi: 10.1158/1940-6207.CAPR-24-0449. PMID: 39718469.
  12. Ashburn NP, Snavely AC, Supples MW, Millard MJ, Allen BR, Christenson RH, Madsen T, Mumma BE, Hashemian T, Wilkerson RG, Mahler SA. Performance of the High-STEACS Early Rule Out Pathway Using hs-cTnT at 30 Days in a Multisite US Cohort. Circ Cardiovasc Qual Outcomes. 2025 Feb;18(2):e011084. doi: .1161/CIRCOUTCOMES.124.011084. Epub 2025 Jan 9. PMID: 39781769; PMCID: PMC11902900.
  13. Supples MW, Dameron AG, Powell S, Snavely AC, Ashburn NP, Allen BR, Christenson RH, Wilkerson RG, Mumma BE, Madsen TE, Mahler SA. The HET (history, electrocardiogram, and troponin) score has low efficacy and negative predictive value in a multisite U.S. cohort study. Am J Emerg Med. 2025 Mar;89:151-158. doi: 10.1016/j.ajem.2024.12.012. Epub 2024 Dec 15. PMID: 39729682.
  14. Bima P, Lopez-Ayala P, Koechlin L, Morello F, Boeddinghaus J, Dimitrova M, Spagnuolo CC, Kaplan E, Nestelberger T, Glaeser J, Wildi K, du Fay de Lavallaz J, Morawiec B, Miro O, Martínez-Nadal G, Martin-Sanchez FJ, Christ M, Slankamenac K, Labarile G, Lindahl B, Giannitsis E, Lupia E, Mueller C; APACE and TRAPID-AMI Investigators. Derivation and Validation of ESC-0/1-h Algorithm for High-Sensitivity Troponin T and I in Cancer Patients. JACC Adv. 2025 Jun;4(6 Pt 1):101821. doi: 10.1016/j.jacadv.2025.101821. Epub 2025 May 22. PMID: 40408798; PMCID: PMC12152628.
  15. DiPasquale C, Christenson RH, Donnelly JG, Evans SA, Wu AHB, Olson EG, Barr R, Kosa N, McKenzie H, Abigania M, Jacobson JW. Equivalence between Capillary Blood and Venous Blood Test Results Using Miniaturized Assays and Novel Collection Methods to Support Routine Bloodwork. J Appl Lab Med. 2025 Sep 3;10(5):1090-1104. doi: 10.1093/jalm/jfaf059. PMID: 40387130.

 

Christopher R. deFilippi, MD, MS

  1. Walpert AR, Gupta M, Dunderdale CN, Haptu HH, Manandhar M, deFilippi CR, Burdo TH, Lee H, Kwong RY, Srinivasa S. Exploring the PREVENT HF score and myocardial function among persons with HIV. AIDS. 2025;39:1592-1597. doi: 10.1097/QAD.0000000000004252.
  2. Chitsazan M, Parekh JK, Kosyakovsky LB, Nemeth SM, Lau ES, Januzzi JL Jr, Wang TJ, Levy D, Ndumele CE, Selvin E, Ballantyne C, Psaty BM, Gottdiener JS, Kizer JR, deFilippi CR, Allen NB, de Boer RA, Shah SJ, Ho JE. Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity. Circ Heart Fail. 2025:e013112. doi: 10.1161/CIRCHEARTFAILURE.125.013112. Epub ahead of print.
  3. O'Connor CM, Rathwell S, Mehrotra DV, Corda S, McMULLAN CJ, Lam CSP, Ezekowitz JA, Piekse B, Hernandez AF, Anstrom KJ, Mentz RJ, deFilippi CR, Voors A, Ponikowski P, Butler J, Westerhout CM, Armstrong PW; VICTORIA Study Group. Assessing Benefit in Patients With Heart Failure and Reduced Ejection Fraction: Analysis of the VICTORIA Trial Using Novel Prognostic Risk Stratification. J Card Fail. 2025:S1071-9164(25)00373-2. doi: 10.1016/j.cardfail.2025.07.024. Epub ahead of print.
  4. Kolossváry M, Sereti I, Zanni MV, Fichtenbaum CJ, Aberg JA, Bloomfield GS, Malvestutto CD, Currier JS, Chu SM, Diggs MR, Lu AB, deFilippi C, Foldyna B, McCallum S, Sponseller CA, Lu MT, Douglas PS, Ribaudo HJ, Grinspoon SK. Statin-dependent and -independent pathways are associated with major adverse cardiovascular events in people with HIV. J Clin Invest. 2025 Sep 9:e196021. doi: 10.1172/JCI196021. Epub ahead of print.
  5. Memon M, Christenson RH, Jacobsen G, Apple FS, Singer AJ, Limkakeng AT Jr, Peacock WF, deFilippi CR, Miller JB, McCord J. Utility of N-Terminal Pro-B-Type Natriuretic Peptide-to-Troponin and BNP-to-Troponin Ratios for Differentiating Type 1 from Type 2 Myocardial Infarction: A HIGH-US Sub-Study. Crit Pathw Cardiol. 2025. doi: 10.1097/HPC.0000000000000399. Epub ahead of print.
  6. Moumneh MB, Forman DE, Damluji AA, deFilippi CR. Evolving Insights Regarding Biomarkers to Better Manage Older Adults With Cardiovascular Disease. J Appl Lab Med. 2025 Oct 3:jfaf156. doi: 10.1093/jalm/jfaf156. Epub ahead of print.
  7. Daniels LB, Ajongwen P, Christenson RH, Clark CL, Diercks DB, Fermann GJ, Mace SE, Mahler SA, Pang PS, Rafique Z, Runyon MS, Tauras J, deFilippi CR. Clinical Performance of an N-Terminal Pro-B-Type Natriuretic Peptide Assay in Acute Heart Failure Diagnosis. J Appl Lab Med. 2025;10:325-338. doi: 10.1093/jalm/jfae107.
  8. Shuter J, Davis OA, deFilippi C, Christenson R, Li L, Potts W, Himelhoch S. Nicotine metabolite ratio in people with HIV who smoke cigarettes receiving pharmacologic and behavioral cessation therapy. Cancer Prev Res (Phila). 2025;18:111-115. doi: 10.1158/1940-6207.CAPR-24-0449.
  9. Parashar Y; Awwad A; Bagchi S; Claggett B; Siddiqui SA; Ogheneochuko AW; Christie M Ballantyne CM; deFilippi C. A meta-analysis and systematic review of cardiac troponin I vs. T in community-dwelling adults: is specificity at risk? Clin Chem. doi: 10.1093/clinchem/hvaf023. Epub ahead of print.
  10. Chevli PA, Selvaraj S, Jaeger BC, Hammoud A, Connelly MA, deFilippi C, Lima JAC, Khan SS, Herrington DM, Shapiro MD, Vaduganathan M. Integrating Ketone Bodies in Multi-Marker Risk Prediction of Incident Heart Failure in the Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Prev Cardiol. 2025 Mar 21:zwaf168. doi: 10.1093/eurjpc/zwaf168. Epub ahead of print. PMID: 40116814.
  11. Doudesis D, Lee KK, Anwar M, Singer AJ, Hollander JE, Chenevier-Gobeaux C, Claessens YE, Wussler D, Weil D, Kozhuharov N, Strebel I, Sabti Z, deFilippi C, Seliger S, Mesquita ET, Wiemer JC, Möckel M, Coste J, Jourdain P, Kimiaki K, Yoshimura M, Ibrahim I, Ooi SBS, Sen Kuan W, Gegenhuber A, Mueller T, Hanon O, Vidal JS, Cameron P, Lam L, Freedman B, Chung T, Collins SP, Lindsell CJ, Newby DE, Japp AG, Shah ASV, Villacorta H, Richards AM, McMurray JJV, Mueller C, Januzzi JL, Mills NL. Machine learning to optimise use of natriuretic peptides in the diagnosis of acute heart failure. Eur Heart J Acute Cardiovasc Care. 2025 Apr 12:zuaf051. doi: 10.1093/ehjacc/zuaf051. Epub ahead of print. PMID: 40219913.
  12. Shah ASV, Keene SJ, Pennells L, Kaptoge S, Kimenai DM, Walker M, Halley JD, Rocha S, Hoogeveen RC, Gudnason V, Bakker SJL, Wannamethee SG, Pareek M, Eggers KM, Jukema JW, Hankey GJ, deLemos JA, Ford I, Omland T, Lyngbakken MN, Psaty BM, deFilippi CR, Wood AM, Danesh J, Welsh P, Sattar N, Mills NL, Di Angelantonio E; CAPRICE Co-Investigators. Cardiac Troponins and Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis. J Am Coll Cardiol. 2025;85:1471-1484. doi: 10.1016/j.jacc.2025.02.016. PMID: 40204376.
  13. Kushner, PR, Fonseca V, Nichols JH, Shubrook JH, Miller E, Wight E, deFilippi C, Vassalotti JA. Clinical Need for Point-of-Care Testing in Diabetes in CLIA-Waived Environments. Clin Diabetes. 2024;43:227-239. doi: 10.2337/cd24-0071. eCollection 2025 Spring. PMID: 40290824.
  14. Lu MT, Ribaudo HJ, McCallum S, Zanni MV, deFilippi C, Taron J, Karady J, Foldyna B, Paradis K, Chu SM, Diggs MR, Burdo TH, Currier JS, Bloomfield GS, Fichtenbaum CJ, Malvestutto CD, Aberg JA, Mayrhofer T, Douglas PS, Grinspoon SK; REPRIEVE Investigators. Coronary Plaque, Inflammation, Subclinical Myocardial Injury, and Major Adverse Cardiovascular Events in the REPRIEVE Substudy. JACC Adv. 2025 May 14;4(6 Pt 1):101781. doi: 10.1016/j.jacadv.2025.101781. Epub ahead of print. PMID: 40373520.
  15. Walpert AR, Gupta M, Dunderdale CN, Haptu HH, Manandhar M, deFilippi CR, Burdo TH, Lee H, Kwong RY, Srinivasa S. Exploring the PREVENT HF score and myocardial function among persons with HIV. AIDS. 2025 Jun 5. doi: 10.1097/QAD.0000000000004252. Epub ahead of print. PMID: 40478895.
  16. Cai X, White Q, Johnson WC, Hansen SL, Dardari ZA, Blaha M, Michos ED, Lima JA, deFilippi CR, Budoff MJ, Watson KE, McClelland RL, Yang EH. Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort. JACC Adv. 2025;4(7):101884. doi: 10.1016/j.jacadv.2025.101884. Epub ahead of print. PMID: 40527284; PMCID: PMC12213292.
  17. Tomar S, Lidani KCF, Moraes AAI, Huang S, Oakley C, Nasir K, Blaha MJ, Heckbert SR, Hughes TM, deFilippi CR, Sandoval Y, Jaffe AS, DeFilippis AP. Subclinical Myocardial Injury and Global Cognitive Performance: MESA (Multi-Ethnic Study of Atherosclerosis). JACC Adv. 2025 Jun 23;4(8):101894. doi: 10.1016/j.jacadv.2025.101894. Epub ahead of print. PMID: 40555139; PMCID: PMC12226125.
  18. Goldberg JF, deFilippi CR, Lockhart C, McNair ER, Sinha SS, Kong H, Najjar SS, Lohmar BJ, Tchoukina I, Shah K, Feller E, Hsu S, Rodrigo ME, Jang M, Marboe CC, Berry GJ, Valantine HA, Agbor-Enoh S, Shah P. Proteomics in Acute Heart Transplant Rejection, on Behalf of the GRAfT Investigators. Transplantation. 2025 Jul 1;109(7):1230-1240. doi: 10.1097/TP.0000000000005258. Epub 2024 Dec 3. PMID: 39630098; PMCID: PMC12130342.

2024

2024 Publications

Robert H. Christenson, PhD

  1. Christenson RH. Commentary on Resolved Myositis, Normal CPK, and Peaking Cardiac Troponin T. J Appl Lab Med. 2024 Jul 1;9(4):853-854. doi: 10.1093/jalm/jfae047. PMID: 38712710.
  2. Petriceks AH, Appel LJ, Miller ER 3rd, Mitchell CM, Schrack JA, Wanigatunga AA, Michos ED, Christenson RH, Rebuck H, Juraschek SP. Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease. J Gerontol A Biol Sci Med Sci. 2024 Nov 1;79(11):glae234. doi: 10.1093/gerona/glae234. PMID: 39292998; PMCID: PMC11561395.
  3. Morales-Alvarez MC, Nissaisorakarn V, Appel LJ, Miller ER 3rd, Christenson RH, Rebuck H, Rosas SE, William JH, Juraschek SP. Effects of Reduced Dietary Sodium and the DASH Diet on GFR: The DASH-Sodium Trial. Kidney360. 2024 Apr 1;5(4):569-576. doi: 10.34067/KID.0000000000000390. Epub 2024 Feb 8. PMID: 38326949; PMCID: PMC11093532.
  4. Boegner DJ, Na M, Harris AD, Christenson RH, Damcott CM, King B, Stubbs L, Rock P, White IM. Sample-to-Answer Detection of SARS-CoV-2 Viremia Using Thermally Responsive Alkane Partitions. Anal Chem. 2024 Jul 23;96(29):12049-12056. doi: 10.1021/acs.analchem.4c02105. Epub 2024 Jul 8. PMID: 38975928; PMCID: PMC11724521.
  5. Wu AHB, Jaffe AS, Peacock WF, Kavsak P, Greene D, Christenson RH. The Role of Artificial Intelligence for Providing Scientific Content for Laboratory Medicine. J Appl Lab Med. 2024 Mar 1;9(2):386-393. doi: 10.1093/jalm/jfad095. PMID: 38102068.
  6. Ashburn NP, McCord JK, Snavely AC, Christenson RH, Apple FS, Nowak RM, Peacock WF, deFilippi CR, Mahler SA. Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins? Circulation. 2024 Jan 2;149(1):70-72. doi: 10.1161/CIRCULATIONAHA.123.065030. Epub 2023 Dec 28. PMID: 38153992; PMCID: PMC10756639.
  7. Fang M, Zhang S, Tang O, Christenson RH, Brady T, McEvoy JW, Selvin E. Determinants of High-Sensitivity Cardiac Troponin T and I in US Children and Adolescents. J Am Heart Assoc. 2024 Jun 18;13(12):e035142. doi: 10.1161/JAHA.123.035142. Epub 2024 Jun 6. PMID: 38842269; PMCID: PMC11255754.
  8. Ondracek CR, Melanson SEF, Doan L, Schulz KM, Kleinman S, Zhao Z, Kumanovics A, Wu AHB, Wiencek J, Meng QH, Apple FS, Koch D, Vesper H, Pokuah F, Bryksin J, Myers GL, Christenson RH, Zhang YV. Large-Scale Scientific Study Led by a Professional Organization during the COVID-19 Pandemic: Operations, Best Practices, and Lessons Learned. J Appl Lab Med. 2024 Mar 1;9(2):371-385. doi: 10.1093/jalm/jfad089. PMID: 38059919.
  9. Pickering JW, Kavsak P, Christenson RH, Troughton RW, Pemberton CJ, Richards AM, Joyce L, Than MP. Determination of Clinically Acceptable Analytical Variation of Cardiac Troponin at Decision Thresholds. Clin Chem. 2024 Jul 5;70(7):967-977. doi: 10.1093/clinchem/hvae059. PMID: 38712541.
  10. Coudray MS, Hansel S, Alesci S, Meyer WA 3rd, Christenson RH, Landry LG, Edwards C, Puckrein G, Forney DJ, Akinboboye O. Vitamin D Levels and SARS-CoV-2 Infection among Medically Underserved Populations in the Minority and Rural Coronavirus Insights Study. Viruses. 2024 Apr 19;16(4):639. doi: 10.3390/v16040639. PMID: 38675979; PMCID: PMC11053904.
  11. Christenson RH, Hansel S, II'yasova D, Meyer WA 3rd, Puckrein G, Lee L, Landry LG, Akinboboye O. Nucleocapsid and Spike Protein-Based Anti-SARS-CoV-2 Assay Performance in the Minority and Rural Coronavirus Insights Study: Characteristics of Socioeconomically Disadvantaged Populations with Health Disparities. J Appl Lab Med. 2024 May 2;9(3):493-501. doi: 10.1093/jalm/jfad126. PMID: 38384143.
  12. Supples MW, Snavely AC, Ashburn NP, Allen BR, Christenson RH, Nowak R, Wilkerson RG, Mumma BE, Madsen T, Stopyra JP, Mahler SA. Performance of the 0/2-hour high-sensitivity cardiac troponin T diagnostic protocol in a multisite United States cohort. Acad Emerg Med. 2024 Mar;31(3):239-248. doi: 10.1111/acem.14827. Epub 2024 Jan 8. PMID: 37925594.
  13. Supples MW, Snavely AC, O'Neill JC, Ashburn NP, Allen BR, Christenson RH, Nowak R, Wilkerson RG, Mumma BE, Madsen T, Stopyra JP, Mahler SA. Sex and race differences in the performance of the European Society of Cardiology 0/1-h algorithm with high-sensitivity troponin T. Clin Cardiol. 2024 Feb;47(2):e24199. doi: 10.1002/clc.24199. Epub 2023 Dec 13. PMID: 38088463; PMCID: PMC10823440.
  14. Zhang YV, Kumanovics A, Wiencek J, Melanson SEF, Love T, Wu AHB, Zhao Z, Meng QH, Koch DD, Apple FS, Ondracek CR, Christenson RH. Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response. Viruses. 2024 Feb 14;16(2):292. doi: 10.3390/v16020292. PMID: 38400067; PMCID: PMC10891747.
  15. Foti K, Wang D, Tang O, Daya NR, Commodore-Mensah Y, Juraschek SP, Christenson RH, Selvin E, McEvoy JW. Modeling the Impact of Biomarker-Guided Versus ASCVD Risk-Guided Drug Treatment in US Adults With Stage 1 Hypertension: The National Health and Nutrition Examination Survey, 1999 to 2004. Hypertension. 2024 Jul;81(7):1599-1608. doi: 10.1161/HYPERTENSIONAHA.123.22665. Epub 2024 May 1. PMID: 38690651; PMCID: PMC11168872.
  16. McEvoy JW, Wang D, Tang O, Fang M, Ndumele CE, Coresh J, Christenson RH, Selvin E. Four high sensitivity troponin assays and mortality in US adults with cardiovascular disease: The national health and nutrition examination survey, 1999-2004. Am J Prev Cardiol. 2024 Jan 15;17:100631. doi: 10.1016/j.ajpc.2023.100631. PMID: 38304389; PMCID: PMC10832369.
  17. Ashburn NP, Snavely AC, Allen BR, Christenson RH, Madsen T, McCord JK, Mumma BE, Hashemian T, Stopyra JP, Wilkerson RG, Mahler SA. Performance of the European Society of Cardiology 0/1-hour algorithm with high-sensitivity cardiac troponin T at 90 days among patients with known coronary artery disease. Am J Emerg Med. 2024 May;79:111-115. doi: 10.1016/j.ajem.2024.02.029. Epub 2024 Feb 23. PMID: 38417221.

 

Christopher R. deFilippi, MD, MS

  1. Ashburn NP, McCord JK, Snavely AC, Christenson RH, Apple FS, Nowak RM, Peacock WF, deFilippi CR, Mahler SA. Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins? 2024;149:70-72.
  2. Barasch E, Gottdiener J, Buzkova P, Cappola A, Shah S, deFilippi C, Gardin J and Kizer JR. Association of thyroid dysfunction in individuals≥ 65 years of age with subclinical cardiac abnormalities. The Journal of Clinical Endocrinology & Metabolism. 2024 Sep 16;109(10):e1847-e1856.
  3. deFilippi CR, Parashar Y and Awwad A. Systematic Review and Meta-Analysis of Renal Biomarkers for Cardiovascular Prognosis: A Look Under the Hood. JACC: Advances. 2024;3:100764.
  4. Leung JM, Wu MJ, Kheradpour P, Chen C, Drake KA, Tong G, Ridaura VK, Zisser HC, Conrad WA, Hudson N, Allen J, Welberry C, Parsy-Kowalska C, Macdonald I, Tapson VF, Moy JN, deFilippi CR, Rosas IO, Basit M, Krishnan JA, Parthasarathy S, Prabhakar BS, Salvatore M, Kim CC. Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals. Front Immunol. 2024;15:1348041. doi: 10.3389/fimmu.2024.1348041.
  5. Lu MT, Ribaudo H, Foldyna B, Zanni MV, Mayrhofer T, Karady J, Taron J, Fitch KV, McCallum S, Burdo TH, Paradis K, Hedgire SS, Meyersohn NM, deFilippi C, Malvestutto CD, Sturniolo A, Diggs M, Siminski S, Bloomfield GS, Alston-Smith B, Desvigne-Nickens P, Overton ET, Currier JS, Aberg JA, Fichtenbaum CJ, Hoffmann U, Douglas PS, Grinspoon SK; REPRIEVE Trial Writing Group. Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial. JAMA Cardiol. 2024 Apr 1;9(4):323-334. doi: 10.1001/jamacardio.2023.5661. Epub ahead of print.
  6. Murtagh G, deFilippi C, Zhao Q, Barac A. Circulating biomarkers in the diagnosis and prognosis of immune checkpoint inhibitor-related myocarditis: time for a risk-based approach. Front Cardiovasc Med. 2024;11:1350585. doi: 10.3389/fcvm.2024.1350585.
  7. Bansal N, Katz R, Seliger S, deFilippi C, Wettersten N, de Lemos JA, Christenson R, Killeen AA, Berry JD, Shlipak MG, Ix JH. Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial. Circulation. 2024 Mar 19;149(12):967-969. doi: 10.1161/CIRCULATIONAHA.123.066377.
  8. Naghavi M, Yankelevitz D, Reeves AP, Budoff MJ, Li D, Atlas K, Zhang C, Atlas TL, Lirette S, Wasserthal J, Roy SK, Henschke C, Wong ND, deFilippi C, Heckbert SR, Greenland P. AI-enabled left atrial volumetry in coronary artery calcium scans (AI-CACTM) predicts atrial fibrillation as early as one year, improves CHARGE-AF, and outperforms NT-proBNP: The multi-ethnic study of atherosclerosis. J Cardiovasc Comput Tomogr. 2024 Jul-Aug;18(4):383-391. doi: 10.1016/j.jcct.2024.04.005.
  9. Naghavi M, Reeves A, Budoff M, Li D, Atlas K, Zhang C, Atlas T, Roy SK, Henschke CI, Wong ND, deFilippi C, Levy D, Yankelevitz DF. AI-enabled cardiac chambers volumetry in coronary artery calcium scans (AI-CACTM) predicts heart failure and outperforms NT-proBNP: The multi-ethnic study of Atherosclerosis. J Cardiovasc Comput Tomogr. 2024 Jul-Aug;18(4):392-400. doi: 10.1016/j.jcct.2024.04.006.
  10. Greene SJ, Chambers R, Lerman JB, Harrington J, deFilippi CR, Wendell DC, Kim HW, Green CL, Butler J, Felker GM. Sacubitril/valsartan and cardiovascular biomarkers among patients with recent COVID-19 infection: The PARACOR-19 randomized clinical trial. Eur J Heart Fail. 2024 Jun;26(6):1393-1398. doi: 10.1002/ejhf.3199. Epub ahead of print. PMID: 38733160.
  11. Neumann JT, Twerenbold R, Weimann J, Ballantyne CM, Benjamin EJ, Costanzo S, de Lemos JA, deFilippi CR, Di Castelnuovo A, Donfrancesco C, Dörr M, Eggers KM, Engström G, Felix SB, Ferrario MM, Gansevoort RT, Giampaoli S, Giedraitis V, Hedberg P, Iacoviello L, Jørgensen T, Kee F, Koenig W, Kuulasmaa K, Lewis JR, Lorenz T, Lyngbakken MN, Magnussen C, Melander O, Nauck M, Niiranen TJ, Nilsson PM, Olsen MH, Omland T, Oskarsson V, Palmieri L, Peters A, Prince RL, Qaderi V, Vasan RS, Salomaa V, Sans S, Smith JG, Söderberg S, Thorand B, Tonkin AM, Tunstall-Pedoe H, Veronesi G, Watanabe T, Watanabe M, Zeiher AM, Zeller T, Blankenberg S, Ojeda F. Prognostic Value of Cardiovascular Biomarkers in the Population. JAMA. 2024;331:1898-1909. doi: 10.1001/jama.2024.5596.
  12. Tromp J, Lam CSP, Alemayehu W, de Filippi CR, Melenovský V, Sliwa K, Lopatin Y, Arango JL, Bahit MC, Roessig L, O'Connor CM, Shah P, Westerhout CM, Voors AA, Pieske B, Armstrong PW; VICTORIA Study Group. Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial. Eur J Heart Fail. 2024 Oct;26(10):2231-2239. doi: 10.1002/ejhf.3397.
  13. Vigen R, Ayers C, Berry J, Rohatgi A, Nambi V, Ballantyne CM, Omland T, deFilippi CR, de Lemos J. Individual and Joint Associations of High-Sensitivity Troponin I and High-Sensitivity Troponin T with Cardiac Phenotypes and Outcomes in the General Population: An Analysis From the Dallas Heart Study. J Am Heart Assoc. 2024 Jul 2;13(13):e034549. doi: 10.1161/JAHA.124.034549.
  14. deFilippi CR, McCallum S, Markella ZV, Fitch KV, Diggs MR, Bloomfield GS, Fichtenbaum CJ, Aberg JA, Malvestutto CD, Pinto-Martinez A, Stapleton A, Duggan J, Robbins GK, Taron J, Karady J, Foldyna, B, Lu MT, Ribaudo HJ, Douglas PS, Grinspoon SK. Association of cardiac troponin T with coronary atherosclerosis in asymptomatic primary prevention people with HIV. JACC: Advances 2024 Aug 16;3(9):101206. doi.org/10.1016/j.jacadv.2024.101206.
  15. Barac, A, Wadlow, R, Deeken, J, deFilippi CR. Cardiac Troponin I and T in ICI Myocarditis Screening, Diagnosis, and Prognosis. J Am Coll Cardiol CardioOnc. 2024 Aug 6;6(5):804-807. .https://doi.org/10.1016/j.jaccao.2024.07.001
  16. Phan V, Richards T, Kang K, Sheridan M, Levorson R, deFilippi C, Yang E. Seroprevalence of SARS-CoV-2 in pediatric hematology-oncology patients. Pediatr Blood Cancer. 2024:e31212. 2024;71:e31212. doi: 10.1002/pbc.31212. doi: 10.1002/pbc.31212.
  17. deFilippi CR, Shah P, Shah SJ, Alemayehu W, Lam CP, Butler J, Roessig L, O’Connor CM, Westerhout CM, Armstrong PW. Proteomics identify clinical phenotypes and predict functional outcomes in heart failure with preserved ejection fraction: Insights from VITALITY-HFpEF. Circ Heart Fail. 2024 Sep;17(9):e011792. doi: 10.1161/CIRCHEARTFAILURE.124.011792
  18. Cai X, White Q, Wang DR, deFilippi CR, Bertoni AG, Wu CO, Liu K, Lima JAC, Budoff MJ, Fonarow GC, Watson KE, McClelland RL, Yang EH. Cardiovascular Risks and Outcomes Among Chinese American Immigrants: Insights From the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc. 2024 Sep 17;13(18):e037114. doi: 10.1161/JAHA.124.037114.
  19. Damluji AA, Bruce SA, Reeves G, Pastva AM, Bertoni AG, Mentz RJ, Whellan DJ, Kitzman DW, deFilippi CR. Circulating Biomarkers as Predictors of Improvement in Physical Function in Hospitalized Older Adults with Geriatric Syndromes: Findings from the REHAB-HF Trial. medRxiv 2024.09.13.24313662; doi: https://doi.org/10.1101/2024.09.13.24313662 (pre-press)
  20. Tan ESJ, Choi H, deFilippi CR, Oon YY, Chan SP, Gong L, Lunaria JB, Liew OW, Chong JP, Tay EL, Soo WM, Yip JW, Yong QW, Lee EM, Daniel Yeo PS, Ding ZP, Tang HC, Ewe SH, Chin CWL, Chai SC, Goh PP, Ling LF, Ong HY, Richards AM, Ling LH. Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes. J Am Heart Assoc. 2024 Sep 30:e035486. doi: 10.1161/JAHA.124.035486. Epub ahead of print.
  21. Awwad A, Parashar Y, Bagchi S, Siddiqui SA, Ogheneochuko AW, deFilippi C. Preclinical Screening for Cardiovascular Disease with High-Sensitive Cardiac Troponins:Ready, Set, Go? Front Cardiovasc Med. 2024 Nov 14:11:1350573. doi: 10.3389/fcvm.2024.1350573.
  22. Kolossváry M, Schnittman SR, Zanni MV, Fitch KV, Fichtenbaum CJ, Aberg JA, Bloomfield GS, Malvestutto CD, Currier J, Diggs MR, deFilippi C, Eckard AR, Curran A, Centinbas M, Sadreyev R, Foldyna B, Mayrhofer T, Karady J, Taron J, McCallum S, Lu MT, Ribaudo HJ, Douglas PS, Grinspoon SK. Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial. JAMA Cardiol. 2025;10:254-264. doi: 10.1001/jamacardio.2024.4115.

2023

2023 Publications

Robert H. Christenson, PhD

  1. Ashburn NP, Snavely AC, O'Neill JC, Allen BR, Christenson RH, Madsen T, Massoomi MR, McCord JK, Mumma BE, Nowak R, Stopyra JP, In't Veld MH, Wilkerson RG, Mahler SA. Performance of the European Society of Cardiology 0/1-Hour Algorithm With High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease. JAMA Cardiol. 2023 Apr 1;8(4):347-356. doi: 10.1001/jamacardio.2023.0031. PMID: 36857071; PMCID: PMC9979014.
  2. Rooney MR, Zhang S, Fang M, Minhas AS, Wallace AS, Grams ME, Echouffo-Tcheugui JB, Christenson RH, Selvin E. Performance of glycated albumin as a biomarker of hyperglycemia in pregnancy: Results from the National Health and Nutrition Examination Survey 1999-2004. Clin Biochem. 2023 Feb;112:67-70. doi: 10.1016/j.clinbiochem.2022.11.008. Epub 2022 Nov 19. PMID: 36414047; PMCID: PMC9870942.
  3. Lai C, Potosky AL, McGuire C, Lobo T, Ahn J, Haddad BR, Richards EW, Anand P, Wright K, Christenson RH, Boyle L, Goy A, Atkins MB. Incidence and Durability of SARS-CoV-2 Antibodies in Patients with Cancer and Health Care Workers following the First Wave of the Pandemic. J Oncol. 2022 Feb 19;2022:8798306. doi: 10.1155/2022/8798306. PMID: 35228845; PMCID: PMC8882049.
  4. Christenson RH. UNIVANTS of Healthcare Excellence: More Than an Award. J Appl Lab Med. 2022 Jun 30;7(4):1009-1011. doi: 10.1093/jalm/jfac035. PMID: 35771879.
  5. McEvoy JW, Daya N, Tang O, Fang M, Ndumele CE, Coresh J, Christenson RH, Selvin E. High-sensitivity troponins and mortality in the general population. Eur Heart J. 2023 Jul 21;44(28):2595-2605. doi: 10.1093/eurheartj/ehad328. PMID: 37264651; PMCID: PMC10361011.
  6. Christenson RH. In the Bubble and on the Ball. J Appl Lab Med. 2023 Nov 2;8(6):1009-1012. doi: 10.1093/jalm/jfad074. PMID: 37902499.
  7. Echouffo-Tcheugui JB, Zhang S, McEvoy JW, Juraschek SP, Fang M, Ndumele CE, Christenson RH, Selvin E. Insulin Resistance and N-Terminal Pro-B-Type Natriuretic Peptide Among Healthy Adults. JAMA Cardiol. 2023 Oct 1;8(10):989-995. doi: 10.1001/jamacardio.2023.2758. PMID: 37672260; PMCID: PMC10483384.
  8. Christenson RH. Pediatric Reference Ranges for Cardiac Biomarkers in Health-Paucity Is the Enemy of Good. J Appl Lab Med. 2023 May 4;8(3):437-439. doi: 10.1093/jalm/jfad013. PMID: 37029554.
  9. Hicks CW, Wang D, McDermott K, Matsushita K, Tang O, Echouffo-Tcheugui JB, McEvoy JW, Christenson RH, Selvin E. Associations of Cardiac Biomarkers With Peripheral Artery Disease and Peripheral Neuropathy in US Adults Without Prevalent Cardiovascular Disease. Arterioscler Thromb Vasc Biol. 2023 Aug;43(8):1583-1591. doi: 10.1161/ATVBAHA.122.318774. Epub 2023 Jun 15. PMID: 37317848; PMCID: PMC10526698.
  10. Neumann JT, Twerenbold R, Ojeda F, Aldous SJ, Allen BR, Apple FS, Babel H, Christenson RH, Cullen L, Di Carluccio E, Doudesis D, Ekelund U, Giannitsis E, Greenslade J, Inoue K, Jernberg T, Kavsak P, Keller T, Lee KK, Lindahl B, Lorenz T, Mahler SA, Mills NL, Mokhtari A, Parsonage W, Pickering JW, Pemberton CJ, Reich C, Richards AM, Sandoval Y, Than MP, Toprak B, Troughton RW, Worster A, Zeller T, Ziegler A, Blankenberg S; ARTEMIS study group. Personalized diagnosis in suspected myocardial infarction. Clin Res Cardiol. 2023 Sep;112(9):1288-1301. doi: 10.1007/s00392-023-02206-3. Epub 2023 May 2. PMID: 37131096; PMCID: PMC10449973.
  11. Fang M, Wang D, Tang O, McEvoy JW, Echouffo-Tcheugui JB, Christenson RH, Selvin E. Subclinical Cardiovascular Disease in US Adults With and Without Diabetes. J Am Heart Assoc. 2023 Jun 6;12(11):e029083. doi: 10.1161/JAHA.122.029083. Epub 2023 May 31. PMID: 37254959; PMCID: PMC10381986.
  12. Mu S, Echouffo-Tcheugui JB, Ndumele CE, Coresh J, Juraschek S, Brady T, McEvoy JW, Ozkan B, Tang O, Christenson RH, Selvin E. NT-proBNP Reference Intervals in Healthy U.S. Children, Adolescents, and Adults. J Appl Lab Med. 2023 Jul 5;8(4):700-712. doi: 10.1093/jalm/jfad024. PMID: 37279581; PMCID: PMC10320012.
  13. Wanigatunga AA, Chiu V, Cai Y, Urbanek JK, Mitchell CM, Miller ER 3rd, Christenson RH, Rebuck H, Michos ED, Juraschek SP, Walston J, Xue QL, Bandeen-Roche K, Appel LJ, Schrack JA. Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence. Med Sci Sports Exerc. 2023 Feb 1;55(2):281-288. doi: 10.1249/MSS.0000000000003048. Epub 2022 Sep 29. PMID: 36170549; PMCID: PMC9840658.
  14. Boone S, Peacock WF, Wu AHB, Jaffe A, Christenson RH, Ettner FM, Dadkhah S. Concentration of hs-Troponin in small cohort of transgender patients. Clin Chim Acta. 2023 Jan 15;539:66-69. doi: 10.1016/j.cca.2022.12.003. Epub 2022 Dec 8. PMID: 36495928.
  15. McEvoy JW, Tang O, Wang D, Ndumele CE, Coresh J, Christenson RH, Selvin E. Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in U.S. Adults. J Am Coll Cardiol. 2023 May 23;81(20):2028-2039. doi: 10.1016/j.jacc.2023.03.403. PMID: 37197846; PMCID: PMC10300307.
  16. Echouffo-Tcheugui JB, Zhang S, McEvoy JW, Juraschek SP, Coresh J, Christenson RH, Ndumele CE, Selvin E. Body Composition Measures and N-terminal pro-B-type Natriuretic Peptide (NT-pro-BNP) in US Adults. Clin Chem. 2023 Aug 2;69(8):901-914. doi: 10.1093/clinchem/hvad085. PMID: 37477552; PMCID: PMC10478300.
  17. Echouffo-Tcheugui JB, Zhang S, Daya N, McEvoy JW, Tang O, Juraschek SP, Ndumele CE, Coresh J, Christenson RH, Selvin E. NT-proBNP and All-Cause and Cardiovascular Mortality in US Adults: A Prospective Cohort Study. J Am Heart Assoc. 2023 Jun 6;12(11):e029110. doi: 10.1161/JAHA.122.029110. Epub 2023 May 26. PMID: 37232235; PMCID: PMC10382006.
  18. Sullivan VK, Wallace AS, Rooney MR, Zhang S, Fang M, Christenson RH, Selvin E. Inverse Associations between Measures of Adiposity and Glycated Albumin in US Adults, NHANES 1999-2004. J Appl Lab Med. 2023 Jul 5;8(4):751-762. doi: 10.1093/jalm/jfad004. PMID: 36998214; PMCID: PMC10330585.
  19. Daya NR, McEvoy JW, Christenson RH, Tang O, Foti K, Juraschek SP, Selvin E, Echouffo-Tcheugui JB. Prevalence of Elevated NT-proBNP and its Prognostic Value by Blood Pressure Treatment and Control. Am J Hypertens. 2023 Oct 13;36(11):602-611. doi: 10.1093/ajh/hpad065. PMID: 37458697; PMCID: PMC10570660.
  20. Ozkan B, Grams ME, Coresh J, McEvoy JW, Echouffo-Tcheugui JB, Mu SZ, Tang O, Daya NR, Kim H, Christenson RH, Ndumele CE, Selvin E. Associations of N-terminal pro-B-type natriuretic peptide, estimated glomerular filtration rate, and mortality in US adults. Am Heart J. 2023 Oct;264:49-58. doi: 10.1016/j.ahj.2023.05.014. Epub 2023 Jun 7. PMID: 37290699; PMCID: PMC10526685.
  21. McEvoy JW, Wang D, Brady T, Tang O, Ndumele CE, Coresh J, Christenson RH, Selvin E. Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in a Population-Based Sample of US Children and Adolescents. Circulation. 2023 Jul 4;148(1):7-16. doi: 10.1161/CIRCULATIONAHA.122.063281. Epub 2023 Apr 20. PMID: 37078280; PMCID: PMC10330102.
  22. Yang P, Rooney MR, Wallace AS, Kim H, Echouffo-Tcheugui JB, McEvoy JW, Ndumele C, Christenson RH, Selvin E, Rebholz CM. Associations between diet quality and NT-proBNP in U.S. adults, NHANES 1999-2004. Am J Prev Cardiol. 2023 Jul 30;16:100528. doi: 10.1016/j.ajpc.2023.100528. PMID: 37601625; PMCID: PMC10432600.
  23. Ashburn NP, McCord JK, Snavely AC, Christenson RH, Apple FS, Nowak RM, Peacock WF, deFilippi CR, Mahler SA. Navigating the Observation Zone: Do Risk Scores Help Stratify Patients With Indeterminate High-Sensitivity Cardiac Troponins? Circulation. 2024 Jan 2;149(1):70-72. doi: 10.1161/CIRCULATIONAHA.123.065030. Epub 2023 Dec 28. PMID: 38153992; PMCID: PMC10756639.
  24. Zhang YV, Kumanovics A, Wiencek J, Melanson SEF, Love T, Wu AHB, Zhao Z, Meng QH, Koch DD, Apple FS, Ondracek CR, Christenson RH. Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response. Viruses. 2024 Feb 14;16(2):292. doi: 10.3390/v16020292. PMID: 38400067; PMCID: PMC10891747.
  25. Petriceks AH, Appel LJ, Miller ER 3rd, Mitchell CM, Schrack JA, Wanigatunga AA, Michos ED, Christenson RH, Rebuck H, Juraschek SP. Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease. J Gerontol A Biol Sci Med Sci. 2024 Nov 1;79(11):glae234. doi: 10.1093/gerona/glae234. PMID: 39292998; PMCID: PMC11561395.
  26. Selvin E, Wang D, Tang O, Fang M, Christenson RH, McEvoy JW. Elevated Cardiac Biomarkers, Erectile Dysfunction, and Mortality in U.S. Men: NHANES 2001 to 2004. JACC Adv. 2023 Jun;2(4):100380. doi: 10.1016/j.jacadv.2023.100380. Epub 2023 Jun 30. PMID: 37427147; PMCID: PMC10328217.
  27. Zhao Z, Kumanovics A, Love T, Melanson SEF, Meng QH, Wu AHB, Wiencek J, Apple FS, Ondracek CR, Koch DD, Christenson RH, Zhang YV. T Cell Responses Correlate with Self-Reported Disease Severity and Neutralizing Antibody Responses Predict Protection against SARS-CoV-2 Breakthrough Infection. Viruses. 2023 Mar 9;15(3):709. doi: 10.3390/v15030709. PMID: 36992418; PMCID: PMC10058409.
  28. Popp LM, Ashburn NP, Snavely AC, Allen BR, Christenson RH, Madsen T, Mumma BE, Nowak R, Stopyra JP, Wilkerson RG, Mahler SA. Race differences in cardiac testing rates for patients with chest pain in a multisite cohort. Acad Emerg Med. 2023 Oct;30(10):1020-1028. doi: 10.1111/acem.14762. Epub 2023 Jun 19. PMID: 37306075.
  29. Ashburn NP, Snavely AC, O'Neill JC, Allen BR, Christenson RH, Madsen T, Massoomi MR, McCord JK, Mumma BE, Nowak R, Stopyra JP, In't Veld MH, Wilkerson RG, Mahler SA. Performance of the European Society of Cardiology 0/1-Hour Algorithm With High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease. JAMA Cardiol. 2023 Apr 1;8(4):347-356. doi: 10.1001/jamacardio.2023.0031. PMID: 36857071; PMCID: PMC9979014.
  30. Belanger MJ, Kovell LC, Turkson-Ocran RA, Mukamal KJ, Liu X, Appel LJ, Miller ER 3rd, Sacks FM, Christenson RH, Rebuck H, Chang AR, Juraschek SP. Effects of the Dietary Approaches to Stop Hypertension Diet on Change in Cardiac Biomarkers Over Time: Results From the DASH-Sodium Trial. J Am Heart Assoc. 2023 Jan 17;12(2):e026684. doi: 10.1161/JAHA.122.026684. Epub 2023 Jan 11. PMID: 36628985; PMCID: PMC9939071.
  31. Elgebaly SA, Peacock WF, Christenson RH, Kreutzer DL, Faraag AHI, Sarguos AMM, El-Khazragy N. Integrated Bioinformatics Analysis Confirms the Diagnostic Value of Nourin-Dependent miR-137 and miR-106b in Unstable Angina Patients. Int J Mol Sci. 2023 Sep 30;24(19):14783. doi: 10.3390/ijms241914783. PMID: 37834231; PMCID: PMC10573268.
  32. Rooney MR, Zhang S, Fang M, Minhas AS, Wallace AS, Grams ME, Echouffo-Tcheugui JB, Christenson RH, Selvin E. Performance of glycated albumin as a biomarker of hyperglycemia in pregnancy: Results from the National Health and Nutrition Examination Survey 1999-2004. Clin Biochem. 2023 Feb;112:67-70. doi: 10.1016/j.clinbiochem.2022.11.008. Epub 2022 Nov 19. PMID: 36414047; PMCID: PMC9870942.
  33. Supples MW, Snavely AC, O'Neill JC, Ashburn NP, Allen BR, Christenson RH, Nowak R,    Wilkerson RG, Mumma BE, Madsen T, Stopyra JP, Mahler SA. Sex and race differences in the performance of the European Society of Cardiology 0/1-h algorithm with high-sensitivity troponin T. Clin Cardiol. 2024 Feb;47(2):e24199. doi: 10.1002/clc.24199. Epub 2023 Dec 13. PMID: 38088463; PMCID: PMC10823440.
  34. McEvoy JW, Daya N, Tang O, Fang M, Ndumele CE, Coresh J, Christenson RH, Selvin E. High-sensitivity troponins and mortality in the general population. Eur Heart J. 2023 Jul 21;44(28):2595-2605. doi: 10.1093/eurheartj/ehad328. PMID: 37264651; PMCID: PMC10361011.

 

Christopher R. deFilippi, MD, MS

  1. Sigurdardottir FD, Bertisch SM, Reid ML, deFilippi CR, Lima JAC, Redline S, Omland T. Association between insomnia phenotypes and subclinical myocardial injury: The Multi-Ethnic Study of Atherosclerosis. Sleep. 2023 Apr 12;46(4):zsac318. doi: 10.1093/sleep/zsac318.
  2. Barasch E, Gottdiener JS, Tressel W, Bartz TM, Buzkova P, Massera D, deFilippi C, Biggs ML, Psaty BM, Kizer JR, Owens D. The Associations of Aortic Valve Sclerosis, Aortic Annular Increased Reflectivity, and Mitral Annular Calcification with Subsequent Aortic Stenosis in Older Individuals: Findings from the Cardiovascular Health Study. J Am Soc Echocardiogr. 2023;36:41-49.e1.
  3. Minciunescu A, Genovese L, deFilippi C. Cardiovascular Alterations and Structural Changes in the Setting of Chronic Kidney Disease: a Review of Cardiorenal Syndrome Type 4. SN Compr Clin Med. 2023;5(1):15. doi: 10.1007/s42399-022-01347-2.
  4. Saha A, Patel KV, Ayers C, Ballantyne CM, Correa A, defilippi C, Hall ME, Mentz RJ, Seliger SL, Yimer W, Butler J, Berry JD, De Lemos JA, Pandey A. Longitudinal Changes in Cardiac Troponin and Risk of Heart Failure Among Black Adults. J Card Fail. 2023;29:6-15.
  5. Patel KV, Saha A, Ayers CR, Rohatgi A, Berry JD, Almandoz JP, Johannsen NM, deFilippi CR, Church TS, de Lemos JA, Pandey A. JACC Adv. 2023 Jan, 2 (1) 100174.
  6. deFilippi CR, Alemayehu WG, Voors AA, Kaye D, Blaustein RO, Butler J, Ezekowitz JA, Hernandez AF, Lam CSP, Roessig L, Seliger S, Shah P, Westerhout CM, Armstrong PW, O'Connor CM; VICTORIA Study Group. Assessment of Biomarkers of Myocardial injury, Inflammation, and Renal Function in Heart Failure with Reduced Ejection Fraction: The VICTORIA Biomarker Substudy. J Card Fail. 2023 Jan 9:S1071-9164(23)00002-7. doi: 10.1016/j.cardfail.2022.12.013.
  7. deFilippi CR, Tran H, Gattani R, Daniels LB, Shah P, Ilkhanoff L, Christenson R, Lima JA, Seliger S. Association of Prognostic Cardiac and Non-Cardiac Specific Circulating Biomarkers with Replacement and Interstitial Cardiac Fibrosis in Community Dwelling Adults: The Multi-Ethnic Study of Atherosclerosis. Front Cardiovasc Med. 10:1104715. doi: 10.3389/fcvm.2023.1104715.
  8. Tedla YG, Driver S, Szklo M, Kuller L, Lima JA, Michos ED, Ning H, deFilippi CR, Greenland P. Joint effect of highly-sensitive cardiac troponin T and ankle-brachial index on incident cardiovascular events: The MESA and CHS. Am J Prev Cardiol. 2023;13:100471. doi: 10.1016/j.ajpc.2023.100471.
  9. Bakhshi H, Michelhaugh SA, Bruce SA, Seliger SL, Qian X, Venkatesh BA, Varadarajan V, Bagchi P, Lim JA, deFilippi Association between proteomic biomarkers and myocardial fibrosis measured by MRI: The Multi-ethnic Study of Atherosclerosis. EBioMedicine. 2023; Apr:90:104490. doi: 10.1016/j.ebiom.2023.104490.
  10. Shah P, Arias R, deFilippi CR. Redefining Pre–Heart Failure With Cardiac Biomarkers: Clinical and Research Implications. JACC Heart Fail. 2023;11:451-453.
  11. Butler J, Zheng Y, Khan MS, Bonderman D, Lund LH, deFilippi CR, Blaustein RO, Ezekowitz JA, Freitas C and Hernandez AF. Ejection Fraction, Biomarkers, and Outcomes and Impact of Vericiguat on Outcomes Across EF in VICTORIA. JACC Heart Fail. 2023;11:583-592.
  12. Tsutsui H, Albert NM, Coats AJ, Anker SD, Bayes‐Genis A, Butler J, Chioncel O, deFilippi CR, Drazner MH and Felker GM. Natriuretic peptides: role in the diagnosis and management of heart failure: a scientific statement from the Heart Failure Association of the European Society of Cardiology, Heart Failure Society of America and Japanese Heart Failure Society. Eur J Heart Fail. 2023;25:616-631.
  13. Kolossváry M, deFilippi C, McCallum S, Fitch KV, Diggs MR, Fulda ES, Ribaudo HJ, Fichtenbaum CJ, Aberg JA, Malvestutto CD, Currier JS, Casado JL, Gutiérrez F, Sereti I, Douglas PS, Zanni MV and Grinspoon SK. Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV. EBioMedicine. 2023;90:104538. doi: 10.1016/j.ebiom.2023.104538.
  14. Shemesh E, Chevli PA, Islam T, German CA, Otvos J, Yeboah J, Rodriguez F, deFilippi C, Lima JAC, Blaha M, Pandey A, Vaduganathan M and Shapiro MD. Circulating ketone bodies and cardiovascular outcomes: the MESA study. Eur Heart J. 2023;44:1636-1646. doi: 10.1093/eurheartj/ehad087.
  15. Damluji AA, Alfaraidhy M, AlHajri N, Rohant NN, Kumar M, Al Malouf C, Bahrainy S, Ji Kwak M, Batchelor WB, Forman DE, Rich MW, Kirkpatrick J, Krishnaswami A, Alexander KP, Gerstenblith G, Cawthon P, deFilippi CR, Goyal P. Sarcopenia and Cardiovascular Diseases. 2023;147:1534-1553.
  16. O'Lone E, Apple FS, Burton JO, Caskey FJ, Craig JC, deFilippi CR, Forfang D, Hicks KA, Jha V, Mahaffey KW, Mark PB, Rossignol P, Scholes-Robertson N, Jaure A, Viecelli AK, Wang AY, Wheeler DC, White D, Winkelmayer WC and Herzog CA. Defining myocardial infarction in trials of people receiving hemodialysis: consensus report from the SONG-HD MI Expert Working group. Kidney Int. 2023;103:1028-1037.
  17. Goldberg JF, Truby LK, Agbor-Enoh S, Jackson AM, deFilippi CR, Khush KK and Shah P. Selection and Interpretation of Molecular Diagnostics in Heart Transplantation. 2023;148:679-694.
  18. Ilkhanoff L, Qian X, Lima JA, Tran H, Soliman EZ, Yeboah J, Seliger S and deFilippi CR. Electrocardiographic Associations of Cardiac Biomarkers and Cardiac Magnetic Resonance Measures of Fibrosis in the Multiethnic Study of Atherosclerosis (MESA). Am J Cardiol. 2023;204:287-294.
  19. deFilippi C and Barac A. Cardiac Troponins for Diagnosis and Prognostic Assessment of Immune Checkpoint Inhibitor Myocarditis and Myositis: The Emerging Importance of Peripheral Vision. 2023;148:1135-1137.
  20. Rogawski McQuade ET, Becker L, Stroup SE, Khan F, Shah B, Brush J, Goldsmith G, Mullin R, Guilliams D, deFilippi C, Barackman K, Mohr AB, Farrell F, Bearman G, Peake L and Houpt ER. Risk factors and titers of COVID-19 infection in a longitudinal statewide seroepidemiology cohort. BMC Infect Dis. 2023;23:676.

2022

2022 Publications

Robert H. Christenson, PhD

  1. Alshaikh LM, Apple FS, Christenson RH, deFilippi CR, Limkakeng AT Jr, McCord J, Nowak RM, Singer AJ, Peacock WF. Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin. J Am Coll Emerg Physicians Open. 2022 Nov 17;3(6):e12844. doi: 10.1002/emp2.12844. PMID: 36408352; PMCID: PMC9669988.
  2. Stein SR, Ramelli SC, Grazioli A, Chung JY, Singh M, Yinda CK, Winkler CW, Sun J, Dickey JM, Ylaya K, Ko SH, Platt AP, Burbelo PD, Quezado M, Pittaluga S, Purcell M, Munster VJ, Belinky F, Ramos-Benitez MJ, Boritz EA, Lach IA, Herr DL, Rabin J, Saharia KK, Madathil RJ, Tabatabai A, Soherwardi S, McCurdy MT; NIH COVID-19 Autopsy Consortium; Peterson KE, Cohen JI, de Wit E, Vannella KM, Hewitt SM, Kleiner DE, Chertow DS. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature. 2022 Dec;612(7941):758-763. doi: 10.1038/s41586-022-05542-y. Epub 2022 Dec 14. PMID: 36517603; PMCID: PMC9749650.
  3. Neumann JT, Twerenbold R, Ojeda F, Aldous SJ, Allen BR, Apple FS, Babel H, Christenson RH, Cullen L, Di Carluccio E, Doudesis D, Ekelund U, Giannitsis E, Greenslade J, Inoue K, Jernberg T, Kavsak P, Keller T, Lee KK, Lindahl B, Lorenz T, Mahler SA, Mills NL, Mokhtari A, Parsonage W, Pickering JW, Pemberton CJ, Reich C, Richards AM, Sandoval Y, Than MP, Toprak B, Troughton RW, Worster A, Zeller T, Ziegler A, Blankenberg S; ARTEMIS study group. Personalized diagnosis in suspected myocardial infarction. Clin Res Cardiol. 2023 Sep;112(9):1288-1301. doi: 10.1007/s00392-023-02206-3. Epub 2023 May 2. PMID: 37131096; PMCID: PMC10449973.
  4. Echouffo-Tcheugui JB, Zhang S, McEvoy JW, Juraschek SP, Fang M, Ndumele CE, Christenson RH, Selvin E. Insulin Resistance and N-Terminal Pro-B-Type Natriuretic Peptide Among Healthy Adults. JAMA Cardiol. 2023 Oct 1;8(10):989-995. doi: 10.1001/jamacardio.2023.2758. PMID: 37672260; PMCID: PMC10483384.
  5. Fang M, Daya N, Coresh J, Christenson RH, Selvin E. Glycated Albumin for the Diagnosis of Diabetes in US Adults. Clin Chem. 2022 Mar 4;68(3):413-421. doi: 10.1093/clinchem/hvab231. PMID: 35092266; PMCID: PMC8897243.
  6. Wanigatunga AA, Chiu V, Cai Y, Urbanek JK, Mitchell CM, Miller ER 3rd, Christenson RH, Rebuck H, Michos ED, Juraschek SP, Walston J, Xue QL, Bandeen-Roche K, Appel LJ, Schrack JA. Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence. Med Sci Sports Exerc. 2023 Feb 1;55(2):281-288. doi: 10.1249/MSS.0000000000003048. Epub 2022 Sep 29. PMID: 36170549; PMCID: PMC9840658.
  7. Boone S, Peacock WF, Wu AHB, Jaffe A, Christenson RH, Ettner FM, Dadkhah S. Concentration of hs-Troponin in small cohort of transgender patients. Clin Chim Acta. 2023 Jan 15;539:66-69. doi: 10.1016/j.cca.2022.12.003. Epub 2022 Dec 8. PMID: 36495928.
  8. Rooney MR, Daya N, Tang O, McEvoy JW, Coresh J, Christenson RH, Selvin E. Glycated Albumin and Risk of Mortality in the US Adult Population. Clin Chem. 2022 Mar 4;68(3):422-430. doi: 10.1093/clinchem/hvab232. PMID: 35092265; PMCID: PMC8897960.
  9. Susman SJ, Bouffler A, Gordee A, Kuchibhatla M, Leahy JC, Griffin SM, Christenson RH, Newby LK, Limkakeng AT. Stress-Delta B-Type Natriuretic Peptide Does Not Exclude ACS in the ED. J Appl Lab Med. 2022 Sep 1;7(5):1098-1107. doi: 10.1093/jalm/jfac027. PMID: 35587711; PMCID: PMC9939016.
  10. Merrill VD, Ward MD, Diaz-McNair J, Pickett EA, Duh SH, Christenson RH. Assessing Phlebotomy Device Preference and Specimen Quality in an Oncology Outpatient Clinic. J Appl Lab Med. 2022 Mar 2;7(2):532-540. doi: 10.1093/jalm/jfab109. PMID: 34632493.
  11. Limkakeng AT Jr, Hertz J, Lerebours R, Kuchibhatla M, McCord J, Singer AJ, Apple FS, Peacock WF, Christenson RH, Nowak RM. Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction. Am J Emerg Med. 2022 Jun;56:323-324. doi: 10.1016/j.ajem.2021.08.066. Epub 2021 Aug 28. PMID: 34482998.
  12. Kim H, Tang O, Rebholz CM, Grams ME, Coresh J, Christenson RH, Selvin E. Associations of Glycated Albumin and HbA1c with Chronic Kidney Disease in US Adults. J Appl Lab Med. 2022 Jun 30;7(4):842-853. doi: 10.1093/jalm/jfac006. PMID: 35213712; PMCID: PMC9246894.
  13. Greene DN, Schmidt RL, Christenson RH, Rongitsch J, Imborek KL, Rebuck H, Lorey TS, Saenger AK, Krasowski MD. Distribution of High-Sensitivity Cardiac Troponin and N-Terminal Pro-Brain Natriuretic Peptide in Healthy Transgender People. JAMA Cardiol. 2022 Nov 1;7(11):1170-1174. doi: 10.1001/jamacardio.2022.3299. PMID: 36197689; PMCID: PMC9535541.
  14. Koechlin L, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Shrestha S, Wussler D, Haeni N, Walter JE, Twerenbold R, Eckstein FS, Reuthebuch O, McCord J, Nowak RM, Christenson RH, deFilippi CR, Apple FS, Mueller C; APACE and High-US investigators. Lower diagnostic accuracy of hs-cTnI in patients with prior coronary artery bypass grafting. Int J Cardiol. 2022 May 1;354:1-6. doi: 10.1016/j.ijcard.2022.02.025. Epub 2022 Feb 18. PMID: 35189168.
  15. Abboud A, Kui N, Gaggin HK, Ibrahim NE, Chen-Tournoux AA, Christenson RH, Hollander JE, Levy PD, Nagurney JT, Nowak RM, Pang PS, Peacock WF, Walters EL, Januzzi JL. Multiple Cardiac Biomarker Testing Among Patients With Acute Dyspnea From the ICON-RELOADED Study. J Card Fail. 2022 Feb;28(2):226-233. doi: 10.1016/j.cardfail.2021.08.025. Epub 2021 Oct 9. PMID: 34634446.
  16. Alshaikh LM, Apple FS, Christenson RH, deFilippi CR, Limkakeng AT Jr, McCord J, Nowak RM, Singer AJ, Peacock WF. Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin. J Am Coll Emerg Physicians Open. 2022 Nov 17;3(6):e12844. doi: 10.1002/emp2.12844. PMID: 36408352; PMCID: PMC9669988.
  17. Daya NR, Rooney MR, Tang O, Coresh J, Christenson RH, Selvin E. Glycated Albumin in Pristine and Non-Pristine Stored Samples in the National Health and Nutrition Examination Survey (NHANES) 1999-2004. J Appl Lab Med. 2022 Jun 30;7(4):916-922. doi: 10.1093/jalm/jfab168. PMID: 34993541; PMCID: PMC9247021.
  18. Ashburn NP, Snavely AC, Allen BR, Christenson RH, Herrington DM, Hiestand BC, Miller CD, Stopyra JP, Mahler SA. Monocyte chemoattractant protein-1 is not predictive of cardiac events in patients with non-low-risk chest pain. Emerg Med J. 2022 Nov;39(11):853-858. doi: 10.1136/emermed-2021-211266. Epub 2021 Dec 21. PMID: 34933919; PMCID: PMC9209560.
  19. Christenson RH, Frenk LDS, de Graaf HJ, van Domburg TSY, Wijnands FPG, Foolen HWJ, Kemper DWM, Bruinen AL, Meijering BDM, Fonville JM, de Theije FK. Point-of-Care: Roadmap for Analytical Characterization and Validation of a High-Sensitivity Cardiac Troponin I Assay in Plasma and Whole Blood Matrices. J Appl Lab Med. 2022 Jun 30;7(4):971-988. doi: 10.1093/jalm/jfac028. Erratum in: J Appl Lab Med. 2023 Mar 6;8(2):418. doi: 10.1093/jalm/jfac072. PMID: 35660917.
  20. Bansal N, Zelnick LR, Ballantyne CM, Chaves PHM, Christenson RH, Coresh J, deFilippi CR, de Lemos JA, Daniels LB, Go AS, He J, Hedayati SS, Matsushita K, Nambi V, Shlipak MG, Taliercio JJ, Seliger SL; CRIC Study Investigators. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD. Am J Kidney Dis. 2022 Mar;79(3):383-392. doi: 10.1053/j.ajkd.2021.06.017. Epub 2021 Jul 19. PMID: 34293394; PMCID: PMC8766621.
  21. Michos ED, Kalyani RR, Blackford AL, Sternberg AL, Mitchell CM, Juraschek SP, Schrack JA, Wanigatunga AA, Roth DL, Christenson RH, Miller ER 3rd, Appel LJ. The Relationship of Falls With Achieved 25-Hydroxyvitamin D Levels From Vitamin D Supplementation: The STURDY Trial. J Endocr Soc. 2022 Apr 16;6(6):bvac065. doi: 10.1210/jendso/bvac065. PMID: 35592513; PMCID: PMC9113179.
  22. Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022 Aug 1;33(5):376-384. doi: 10.1097/MCA.0000000000001135. Epub 2022 Mar 8. PMID: 35880560.
  23. Peacock WF, Maisel AS, Mueller C, Anker SD, Apple FS, Christenson RH, Collinson P, Daniels LB, Diercks DB, Somma SD, Filippatos G, Headden G, Hiestand B, Hollander JE, Kaski JC, Kosowsky JM, Nagurney JT, Nowak RM, Schreiber D, Vilke GM, Wayne MA, Than M. Finding acute coronary syndrome with serial troponin testing for rapid assessment of cardiac ischemic symptoms (FAST-TRAC): a study protocol. Clin Exp Emerg Med. 2022 Jun;9(2):140-145. doi: 10.15441/ceem.21.154. Epub 2022 Jun 30. PMID: 35843615; PMCID: PMC9288884.

 

Christopher R. deFilippi, MD, MS

  1. Chiang CH, Chiang CH, Pickering JW, Stoyanov KM, Chew DP, Neumann JT, Ojeda F, Sörensen NA, Su KY, Kavsak P, Worster A, Inoue K, Johannessen TR, Atar D, Amann M, Hochholzer W, Mokhtari A, Ekelund U, Twerenbold R, Mueller C, Bahrmann P, Buttinger N, Dooley M, Ruangsomboon O, Nowak RM, deFilippi CR, Peacock WF, Neilan TG, Liu MA, Hsu WT, Lee GH, Tang PU, Ma KS, Westermann D, Blankenberg S, Giannitsis E, Than MP, Lee CC. Performance of the European Society of Cardiology 0/1-Hour, 0/2-Hour, and 0/3-Hour Algorithms for Rapid Triage of Acute Myocardial Infarction: An International Collaborative Meta-analysis. Ann Intern Med. 2022 Jan;175(1):101-113. doi: 10.7326/M21-1499.
  2. Cooper LB, Bruce S, Psotka M, Mentz R, Bell R, Seliger SL, O'Connor C, deFilippi C. Proteomic differences among patients with heart failure taking furosemide or torsemide. Clin Cardiol. 2022 Mar;45(3):265-272. doi: 10.1002/clc.23733.
  3. Koechlin L, Boeddinghaus J, Nestelberger T, Lopez-Ayala P, Shrestha S, Wussler D, Haeni N, Walter JE, Twerenbold R, Eckstein FS, Reuthebuch O, McCord J, Nowak RM, Christenson RH, deFilippi CR, Apple FS, Mueller C; APACE and High-US investigators. Lower diagnostic accuracy of hs-cTnI in patients with prior coronary artery bypass grafting. Int J Cardiol. 2022 Feb 18;S0167-5273.
  4. Rosner CM, Atkins M, Saeed IM, de Lemos JA, Khera A, Maghsoudi A, Min J, Tehrani BN, O'Connor CM, deFilippi CR. Patients With Myocarditis Associated With COVID-19 Vaccination. J Am Coll Cardiol. 2022;79:1317-1319.
  5. Massera D, Hu M, Delaney JA, Bartz TM, Bach ME, Dvorak SJ, deFilippi CR, Psaty BM, Gottdiener JS, Kizer JR, Shah SJ. Adverse cardiac mechanics and incident coronary heart disease in the Cardiovascular Health Study. 2022;108:529-535.
  6. Gottdiener JS, Buzkova P, Kahn PA, deFilippi C, Shah S, Barasch E, Kizer JR, Psaty B, Gardin JM. Relation of Cigarette Smoking and Heart Failure in Adults ≥65 Years of Age (From the Cardiovascular Health Study). Am J Cardiol. 2022;168:90-98.
  7. Kolossváry M, deFilippi C, Lu MT, Zanni MV, Fulda ES, Foldyna B, Ribaudo H, Mayrhofer T, Collier AC, Bloomfield GS, Fichtenbaum C, Overton ET, Aberg JA, Currier J, Fitch KV, Douglas PS, Grinspoon SK. Proteomic Signature of Subclinical Coronary Artery Disease in People with HIV: Analysis of the REPRIEVE Mechanistic Substudy. J Infect Dis. 2022 Nov 11;226(10):1809-1822. doi: 10.1093/infdis/jiac196.
  8. Saha A, Patel KV, Ayers C, Ballantyne CM, Correa A, deFilippi C, Hall ME, Mentz RJ, Seliger SL, Yimer W, Butler J, Berry JD, de Lemos JA, Pandey A. Longitudinal changes in cardiac troponin and risk of heart failure among Black adults. J Card Fail. 2023 Jan;29(1):6-15.
  9. Lee KK, Doudesis D, Anwar M, Astengo F, Chenevier-Gobeaux C, Claessens YE, Wussler D, Kozhuharov N, Strebel I, Sabti Z, deFilippi C, Seliger S, Moe G, Fernando C, Bayes-Genis A, van Kimmenade RRJ, Pinto Y, Gaggin HK, Wiemer JC, Möckel M, Rutten JHW, van den Meiracker AH, Gargani L, Pugliese NR, Pemberton C, Ibrahim I, Gegenhuber A, Mueller T, Neumaier M, Behnes M, Akin I, Bombelli M, Grassi G, Nazerian P, Albano G, Bahrmann P, Newby DE, Japp AG, Tsanas A, Shah ASV, Richards AM, McMurray JJV, Mueller C, Januzzi JL, Mills NL; CoDE-HF investigators. Development and validation of a decision support tool for the diagnosis of acute heart failure: systematic review, meta-analysis, and modelling study. 2022 Jun 13;377:e068424. doi: 10.1136/bmj-2021-068424.
  10. Austin TR, McHugh CP, Brody JA, Bis JC, Sitlani CM, Bartz TM, Biggs ML, Bansal N, Buzkova P, Carr SA, deFilippi CR, Elkind MSV, Fink HA, Floyd JS, Fohner AE, Gerszten RE, Heckbert SR, Katz DH, Kizer JR, Lemaitre RN, Longstreth WT, McKnight B, Mei H, Mukamal KJ, Newman AB, Ngo D, Odden MC, Vasan RS, Shojaie A, Simon N, Smith GD, Davies NM, Siscovick DS, Sotoodehnia N, Tracy RP, Wiggins KL, Zheng J, Psaty BM. Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing. Eur J Epidemiol. 2022 Jul;37(7):755-765. doi: 10.1007/s10654-022-00888-z.
  11. deFilippi CR, Damluji AA. At the Crossroad Between Skeletal and Cardiac Muscle Cells. Circulation. 2022;145:1780-1783.
  12. Shah P, Agbor-Enoh S, Bagchi P, deFilippi CR, Mercado A, Diao G, Morales DJ, Shah KB, Najjar SS, Feller E, Hsu S, Rodrigo ME, Lewsey SC, Jang MK, Marboe C, Berry GJ, Khush KK, Valantine HA; GRAfT Investigators. Circulating microRNAs in cellular and antibody-mediated heart transplant rejection. J Heart Lung Transplant. 2022;S1053-2498
  13. Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Prognosis is worse with elevated cardiac troponin in nonacute coronary syndrome compared with acute coronary syndrome. Coron Artery Dis. 2022;33:376-384.
  14. Bansal N, Katz R, Seliger S, deFilippi C, Wettersten N, Zelnick LR, Berry JD, de Lemos JA, Christenson R, Killeen AA, Shlipak MG, Ix JH. Kidney Function Specific Reference Limits for N-terminal Pro Brain Natriuretic Peptide and High Sensitivity Troponin T: The Systolic Blood Pressure Intervention Trial. Kidney Med. 2022;4:100517.
  15. Tehrani BN, Sherwood MW, Rosner C, Truesdell AG, Ben Lee S, Damluji AA, Desai M, Desai S, Epps KC, Flanagan MC, Howard E, Ibrahim N, Kennedy J, Moukhachen H, Psotka M, Raja A, Saeed I, Shah P, Singh R, Sinha SS, Tang D, Welch T, Young K, deFilippi CR, Speir A, O'Connor CM, Batchelor WB. A Standardized and Regionalized Network of Care for Cardiogenic Shock. JACC Heart Fail. 2022;10:768-781.
  16. deFilippi CR, Seliger S. Malignant Left Ventricular Hypertrophy and Epidemiology 101. J Am Coll Cardiol. 2022;80:1526-1528.
  17. Alshaikh LM, Apple FS, Christenson RH, deFilippi CR, Limkakeng AT Jr, McCord J, Nowak RM, Singer AJ, Peacock WF. Outcomes in ED patients with non-specific ECG findings and low high-sensitivity troponin. J Am Coll Emerg Physicians Open. 2022;3:e12844.
  18. Eltelbany M, Shah P, deFilippi C. Biomarkers in HFpEF for Diagnosis, Prognosis, and Biological Phenotyping. Curr Heart Fail Rep. 2022;19:412-424.

2021

2021 Publications

Robert H. Christenson, PhD

  1. Damluji AA, Christenson RH, deFilippi C. Clinical Application of Serologic Testing for Coronavirus Disease 2019 in Contemporary Cardiovascular Practice. J Am Heart Assoc. 2021 Feb;10(5):e019506. doi: 10.1161/JAHA.120.019506. Epub 2021 Feb 23. PMID: 33619984; PMCID: PMC8174282.
  2. Limkakeng AT Jr, Hertz J, Lerebours R, Kuchibhatla M, McCord J, Singer AJ, Apple FS, Peacock WF, Christenson RH, Nowak RM. Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction. Am J Emerg Med. 2022 Jun;56:323-324. doi: 10.1016/j.ajem.2021.08.066. Epub 2021 Aug 28. PMID: 34482998.
  3. Lopez-Ayala P, Nestelberger T, Boeddinghaus J, Koechlin L, Ratmann PD, Strebel I, Gehrke J, Meier S, Walter J, Rubini Gimenez M, Mutschler E, Miró Ò, López-Barbeito B, Martín-Sánchez FJ, Rodríguez-Adrada E, Keller DI, Newby LK, Twerenbold R, Giannitsis E, Lindahl B, Mueller C; APACE and TRAPID-AMI Investigators†. Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm. Circulation. 2021 Sep 7;144(10):773-787. doi: 10.1161/CIRCULATIONAHA.120.052982. Epub 2021 Aug 11. Erratum in: Circulation. 2021 Dec 7;144(23):e488. doi: 10.1161/CIR.0000000000001045. PMID: 34376064.
  4. Jacob JT, Baker JM, Fridkin SK, Lopman BA, Steinberg JP, Christenson RH, King B, Leekha S, O'Hara LM, Rock P, Schrank GM, Hayden MK, Hota B, Lin MY, Stein BD, Caturegli P, Milstone AM, Rock C, Voskertchian A, Reddy SC, Harris AD. Risk Factors Associated With SARS-CoV-2 Seropositivity Among US Health Care Personnel. JAMA Netw Open. 2021 Mar 1;4(3):e211283. doi: 10.1001/jamanetworkopen.2021.1283. PMID: 33688967; PMCID: PMC7948059.
  5. Abboud A, Kui N, Gaggin HK, Ibrahim NE, Chen-Tournoux AA, Christenson RH, Hollander JE, Levy PD, Nagurney JT, Nowak RM, Pang PS, Peacock WF, Walters EL, Januzzi JL. Multiple Cardiac Biomarker Testing Among Patients With Acute Dyspnea From the ICON-RELOADED Study. J Card Fail. 2022 Feb;28(2):226-233. doi: 10.1016/j.cardfail.2021.08.025. Epub 2021 Oct 9. PMID: 34634446.
  6. Elgebaly SA, Christenson RH, Kandil H, El-Khazragy N, Rashed L, Yacoub B, Eldeeb H, Ali M, Sharafieh R, Klueh U, Kreutzer DL. Nourin-Dependent miR-137 and miR-106b: Novel Early Inflammatory Diagnostic Biomarkers for Unstable Angina Patients. Biomolecules. 2021 Feb 28;11(3):368. doi: 10.3390/biom11030368. PMID: 33670982; PMCID: PMC7997347.
  7. Bransky A, Larsson A, Aardal E, Ben-Yosef Y, Christenson RH. A Novel Approach to Hematology Testing at the Point of Care. J Appl Lab Med. 2021 Mar 1;6(2):532-542. doi: 10.1093/jalm/jfaa186. PMID: 33274357; PMCID: PMC7798949.
  8. Ashburn NP, Snavely AC, Allen BR, Christenson RH, Herrington DM, Hiestand BC, Miller CD, Stopyra JP, Mahler SA. Monocyte chemoattractant protein-1 is not predictive of cardiac events in patients with non-low-risk chest pain. Emerg Med J. 2022 Nov;39(11):853-858. doi: 10.1136/emermed-2021-211266. Epub 2021 Dec 21. PMID: 34933919; PMCID: PMC9209560.
  9. Juraschek SP, Kovell LC, Appel LJ, Miller ER 3rd, Sacks FM, Chang AR, Christenson RH, Rebuck H, Mukamal KJ. Effects of Diet and Sodium Reduction on Cardiac Injury, Strain, and Inflammation: The DASH-Sodium Trial. J Am Coll Cardiol. 2021 Jun 1;77(21):2625-2634. doi: 10.1016/j.jacc.2021.03.320. PMID: 34045018; PMCID: PMC8256779.
  10. Bansal N, Zelnick LR, Ballantyne CM, Chaves PHM, Christenson RH, Coresh J, deFilippi CR, de Lemos JA, Daniels LB, Go AS, He J, Hedayati SS, Matsushita K, Nambi V, Shlipak MG, Taliercio JJ, Seliger SL; CRIC Study Investigators. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD. Am J Kidney Dis. 2022 Mar;79(3):383-392. doi: 10.1053/j.ajkd.2021.06.017. Epub 2021 Jul 19. PMID: 34293394; PMCID: PMC8766621.
  11. Ondracek CR, Melanson SEF, Doan L, Schulz KM, Kleinman S, Zhao Z, Kumanovics A, Wu AHB, Wiencek J, Meng QH, Apple FS, Koch D, Vesper H, Pokuah F, Bryksin J, Myers GL, Christenson RH, Zhang YV. Large-Scale Scientific Study Led by a Professional Organization during the COVID-19 Pandemic: Operations, Best Practices, and Lessons Learned. J Appl Lab Med. 2024 Mar 1;9(2):371-385. doi: 10.1093/jalm/jfad089. PMID: 38059919.
  12. Allen BR, Christenson RH, Cohen SA, Nowak R, Wilkerson RG, Mumma B, Madsen T, McCord J, Huis In't Veld M, Massoomi M, Stopyra JP, Montero C, Weaver MT, Yang K, Mahler SA. Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort. Circulation. 2021 Apr 27;143(17):1659-1672. doi: 10.1161/CIRCULATIONAHA.120.049298. Epub 2021 Jan 21. PMID: 33474976.
  13. Allen BR, Christenson RH, Cohen SA, Weaver MT, Yang K, Mahler SA. Response by Allen et al to Letter Regarding Article, "Diagnostic Performance of High-Sensitivity Cardiac Troponin T Strategies and Clinical Variables in a Multisite US Cohort". Circulation. 2021 Nov 9;144(19):e285-e286. doi: 10.1161/CIRCULATIONAHA.121.056533. Epub 2021 Nov 8. PMID: 34748395.
  14. Appel LJ, Michos ED, Mitchell CM, Blackford AL, Sternberg AL, Miller ER 3rd, Juraschek SP, Schrack JA, Szanton SL, Charleston J, Minotti M, Baksh SN, Christenson RH, Coresh J, Drye LT, Guralnik JM, Kalyani RR, Plante TB, Shade DM, Roth DL, Tonascia J; STURDY Collaborative Research Group. The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults : A Response-Adaptive, Randomized Clinical Trial. Ann Intern Med. 2021 Feb;174(2):145-156. doi: 10.7326/M20-3812. Epub 2020 Dec 8. PMID: 33284677; PMCID: PMC8240534.
  15. Nowak RM, Jacobsen G, Limkakeng A Jr, Peacock WF, Christenson RH, McCord J, Apple FS, Singer AJ, deFilippi CR. Outpatient versus observation/inpatient management of emergency department patients rapidly ruled-out for acute myocardial infarction: Findings from the HIGH-US study. Am Heart J. 2021 Jan;231:6-17. doi: 10.1016/j.ahj.2020.10.067. Epub 2020 Oct 28. PMID: 33127532.
  16. Giannitsis E, Blankenberg S, Christenson RH, Frey N, von Haehling S, Hamm CW, Inoue K, Katus HA, Lee CC, McCord J, Möckel M, Chieh JTW, Tubaro M, Wollert KC, Huber K. Critical appraisal of the 2020 ESC guideline recommendations on diagnosis and risk assessment in patients with suspected non-ST-segment elevation acute coronary syndrome. Clin Res Cardiol. 2021 Sep;110(9):1353-1368. doi: 10.1007/s00392-021-01821-2. Epub 2021 Feb 26. PMID: 33635437; PMCID: PMC8405476.
  17. Ward MD, Mullins KE, Pickett E, Merrill V, Ruiz M, Rebuck H, Duh SH, Christenson RH. Performance of 4 Automated SARS-CoV-2 Serology Assay Platforms in a Large Cohort Including Susceptible COVID-19-Negative and COVID-19-Positive Patients. J Appl Lab Med. 2021 Jul 7;6(4):942-952. doi: 10.1093/jalm/jfab014. PMID: 33693808; PMCID: PMC7989439.
  18. Elgebaly SA, Christenson RH, Kandil H, Ibrahim M, Rizk H, El-Khazragy N, Rashed L, Yacoub B, Eldeeb H, Ali MM, Kreutzer DL. Nourin-Dependent miR-137 and miR-106b: Novel Biomarkers for Early Diagnosis of Myocardial Ischemia in Coronary Artery Disease Patients. Diagnostics (Basel). 2021 Apr 14;11(4):703. doi: 10.3390/diagnostics11040703. PMID: 33919942; PMCID: PMC8070915.

 

Christopher R. deFilippi, MD, MS

  1. Kula AJ, Katz R, Zelnick LR, Soliman E, Go A, Shlipak M, Deo R, Ky B, DeBoer I, Anderson A, Christenson R, Seliger SL, deFilippi C, Feldman HI, Wolf M, Kusek J, Shafi T, He J, Bansal N. Association of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease. Nephrol Dial Transplant. 2021 Dec 2;36(12):2282-2289. doi: 10.1093/ndt/gfaa296.
  2. Bansal N, Zelnick LR, Soliman E, Anderson A, Christenson R, deFilippi C, Deo R, Feldman HI, He J, Ky B, Kusek J, Lash J, Seliger S, Shafi T, Wolf M, Go AS, Shlipak MG; CRIC Study Investigators. Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2021 Jun;77(6):907-919.
  3. Nowak RM, Jacobsen G, Limkakeng A Jr, Peacock WF, Christenson RH, McCord J, Apple FS, Singer AJ, deFilippi CR. Outpatient versus observation/inpatient management of emergency department patients rapidly ruled-out for acute myocardial infarction: Findings from the HIGH-US study. Am Heart J. 2021;231:6-17.
  4. Rogawski McQuade ET, Guertin KA, Becker L, Operario D, Gratz J, Guan D, Khan F, White J, McMurry TL, Shah B, Garofalo S, Southerland M, Bear K, Brush J, Allen C, Frayser A, Vokes R, Pershad R, Peake L, deFilippi C, Barackman K, Bearman G, Bidanset A, Farrell F, Trump D, Houpt ER. Assessment of Seroprevalence of SARS-CoV-2 and Risk Factors Associated With COVID-19 Infection Among Outpatients in Virginia. JAMA Netw Open. 2021;4:e2035234.
  5. Cooper LB, Cotugno A, deFilippi C. Efficacy of Neprilysin in Women with HFpEF: Beyond Phenotypes and Natriuretic Peptides. Circulation. 2021;143:618-620.
  6. Damluji AA, Christenson RH, deFilippi C. Clinical Application of Serologic Testing for Coronavirus Disease 2019 in Contemporary Cardiovascular Practice. J Am Heart Assoc. 2021;10:e019506. DOI: 10.1161/JAHA.120.019506.
  7. deFilippi CR, Mills NL. Rapid Cardiac Troponin Release After Transient Ischemia. Circulation. 2021;143:1105-1108.
  8. Pandey A, Vaduganathan M, Patel KV, Ayers C, Ballantyne CM, Kosiborod MN, Carnethon M, deFilippi C, McGuire DK, Khan SS, Caughey MC, de Lemos JA, Everett BM. Biomarker-Based Risk Prediction of Incident Heart Failure in Pre-Diabetes and Diabetes. JACC Heart Fail. 2021;9:215-223.
  9. Januzzi JL Jr, Canty JM, Das S, deFilippi CR, Gintant GA, Gutstein DE, Jaffe A, Kaushik EP, Leptak C, Mehta C, Pina I, Povsic TJ, Rambaran C, Rhyne RF, Salas M, Shi VC, Udell JA, Unger EF, Zabka TS, Seltzer JH. Gaining Efficiency in Clinical Trials With Cardiac Biomarkers: JACC Review Topic of the Week.  J Am Coll Cardiol. 2021;77:1922-1933.
  10. Bansal N, Zelnick LR, Soliman EZ, Anderson A, Christenson R, deFilippi C, Deo R, Feldman HI, He J, Ky B, Kusek J, Lash J, Seliger S, Shafi T, Wolf M, Go AS, Shlipak MG; CRIC Study Investigators. Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study. Am J Kidney Dis. 2021;77:907-919.
  11. Stevenson LG, deFilippi CR. Swab-Free Transport as an Optimized Preanalytical Workflow for SARS-CoV-2 Molecular Testing. J Appl Lab Med. 2021;6:580-583.
  12. Damluji AA, Rajan D, Haymond A, deFilippi C. Serological Testing for COVID-19 Disease: Moving the Field of Serological Surveillance Forward. J Appl Lab Med. 2021;6:584-587.
  13. Haymond A, Damluji AA, Narayanan A, Mueller C, Reeder A, Alem F, Maxwell GL, Petricoin EF, Liotta L, deFilippi CR. Durability of Viral Neutralization in Asymptomatic Coronavirus Disease 2019 for at Least 60 Days. J Infect Dis. 2021;223:1677-1680.
  14. Massera D, Hu M, Delaney JA, Bartz TM, Bach ME, Dvorak SJ, deFilippi CR, Psaty BM, Gottdiener JS, Kizer JR, Shah SJ. Adverse cardiac mechanics and incident coronary heart disease in the Cardiovascular Health Study. Heart. 2022 Apr;108(7):529-535.
  15. Rao A, Ranka S, Ayers C, Hendren N, Rosenblatt A, Alger HM, Rutan C, Omar W, Khera R, Gupta K, Mody P, deFilippi C, Das SR, Hedayati SS, de Lemos JA. Association of Kidney Disease With Outcomes in COVID-19: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry. Am Heart Assoc. 2021 Jun 15;10(12):e020910.
  16. Damluji AA, Wei S, Bruce SA, Haymond A, Petricoin EF, Liotta L, Maxwell GL, Moore BC, Bell R, Garofalo S, Houpt ER, Trump D, deFilippi CR. Seropositivity of COVID-19 among asymptomatic healthcare workers: A multi-site prospective cohort study from Northern Virginia, United States. Lancet Reg Health Am. 2021 Oct;2:100030. doi: 10.1016/j.lana.2021.100030. Epub 2021 Jul 29.
  17. Patel KV, Simek S, Ayers C, Neeland IJ, deFilippi C, Seliger SL, Lonergan K, Minniefield N, Mentz RJ, Correa A, Yimer WK, Hall ME, Rodriguez CJ, de Lemos JA, Berry JD, Pandey A. Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults. JACC Heart Fail. 2021;9:484-493.
  18. Rosner CM, Genovese L, Tehrani BN, Atkins M, Bakhshi H, Chaudhri S, Damluji AA, de Lemos JA, Desai SS, Emaminia A, Flanagan MC, Khera A, Maghsoudi A, Mekonnen G, Muthukumar A, Saeed IM, Sherwood MW, Sinha SS, O'Connor CM, deFilippi CR. Myocarditis Temporally Associated With COVID-19 Vaccination. Circulation. 2021;144:502-505.
  19. Aurora L, McCord J, Nowak R, Giannitsis E, Christenson R, deFilippi C, Lindahl B, Christ M, Body R, Jacobsen G, Mueller C; TRAPID-AMI Investigators. Prognostic Utility of a Modified HEART Score When Different Troponin Cut Points Are Used. Crit Pathw Cardiol. 2021;20:134-139.
  20. Ezekowitz JA, Zheng Y, Cohen-Solal A, Melenovský V, Escobedo J, Butler J, Hernandez AF, Lam CSP, O'Connor CM, Pieske B, Ponikowski P, Voors AA, deFilippi C, Westerhout CM, McMullan C, Roessig L, Armstrong PW; VICTORIA Study Group. Hemoglobin and Clinical Outcomes in the VerICiguaT Global Study in Patients With Heart Failure and Reduced Ejection Fraction (VICTORIA). Circulation. 2021 Nov 2;144(18):1489-1499.
  21. Garg PK, Lima J, deFilippi CR, Daniels LB, Seliger SL, de Lemos JA, Maisel AS, Criqui MH, Bahrami H. Associations of cardiac injury biomarkers with risk of peripheral artery disease: The Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2021:S0167-5273(21)01495-9.
  22. Bansal N, Zelnick LR, Ballantyne CM, Chaves PHM, Christenson RH, Coresh J, deFilippi CR, de Lemos JA, Daniels LB, Go AS, He J, Hedayati SS, Matsushita K, Nambi V, Shlipak MG, Taliercio JJ, Seliger SL; CRIC Study Investigators. Upper Reference Limits for High-Sensitivity Cardiac Troponin T and N-Terminal Fragment of the Prohormone Brain Natriuretic Peptide in Patients With CKD. Am J Kidney Dis. 2022;79:383-392.
  23. Kula AJ, Katz R, Zelnick LR, Soliman E, Go A, Shlipak M, Deo R, Ky B, DeBoer I, Anderson A, Christenson R, Seliger SL, deFilippi C, Feldman HI, Wolf M, Kusek J, Shafi T, He J, Bansal N. Association of circulating cardiac biomarkers with electrocardiographic abnormalities in chronic kidney disease. Nephrol Dial Transplant 2021;36:2282-2289.
  24. Srinivasa S, deFilippi C, Fitch KV, Iyengar S, Shen G, Burdo TH, Walpert AR, Thomas TS, Adler GK, Grinspoon SK. Evaluation of Mineralocorticoid Receptor Antagonism on Changes in NT-proBNP Among Persons With HIV. J Endocr Soc. 2021 Nov 19;6(1):bvab175. doi: 10.1210/jendso/bvab175.
  25. Shavadia JS, Alemayehu W, deFilippi C, Westerhout CM, Tromp J, Granger CB, Armstrong PW, van Diepen S. Novel multi-marker proteomics in phenotypically matched patients with ST-segment myocardial infarction: association with clinical outcomes. J Thromb Thrombolysis. 2022 May;53(4):841-850. doi: 10.1007/s11239-021-02582-5. Online ahead of print.
  26. Ezekowitz JA, Zheng Y, Cohen-Solal A, Melenovský V, Escobedo J, Butler J, Hernandez AF, Lam CSP, O'Connor CM, Pieske B, Ponikowski P, Voors AA, deFilippi C, Westerhout CM, McMullan C, Roessig L, Armstrong PW. Hemoglobin and Clinical Outcomes in the Vericiguat Global Study in Patients With Heart Failure and Reduced Ejection Fraction (VICTORIA). Circulation. 2021;144:1489-1499.
  27. Yang Y, Bartz TM, Brown MR, Guo X, Zilhão NR, Trompet S, Weiss S, Yao J, Brody JA, defilippi CR, Hoogeveen RC, Lin HJ, Gudnason V, Ballantyne CM, Dörr M, Jukema JW, Petersmann A, Psaty BM, Rotter JI, Boerwinkle E, Fornage M, Jun G, Yu B. Identification of Functional Genetic Determinants of Cardiac Troponin T and I in a Multiethnic Population and Causal Associations With Atrial Fibrillation. Circ Genom Precis Med. 2021;14:e003460. 10.1161/CIRCGEN.121.003460. Epub 2021 Nov 4.
  28. Bakhshi H, Bagchi P, Meyghani Z, Tehrani B, Qian X, Garg PK, Ambale-Venkatesh B, Bhatia HS, Ohyama Y, Wu CO, Budoff M, Allison M, Criqui MH, Bluemke DA, Lima JAC, deFilippi CR. Association of coronary artery calcification and thoracic aortic calcification with incident peripheral arterial disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Eur Heart J Open. 2021 Dec 3;1(3):oeab042. doi: 10.1093/ehjopen/oeab042.

2020

2020 Publications

Robert H. Christenson, PhD

  1. Mullins KE, Christenson RH. Optimal Detection of Acute Myocardial Injury and Infarction with Cardiac Troponin: Beyond the 99th Percentile, into the High-Sensitivity Era. Curr Cardiol Rep. 2020 Aug 4;22(9):101. doi: 10.1007/s11886-020-01350-w. PMID: 32748286.
  2. Christenson RH, Grenache DG, Oellerich M. Special Collection on the Value of Laboratory Medicine. J Appl Lab Med. 2020 Sep 1;5(5):841-843. doi: 10.1093/jalm/jfaa120. PMID: 32916709.
  3. Limkakeng AT Jr, Hertz J, Lerebours R, Kuchibhatla M, McCord J, Singer AJ, Apple FS, Peacock WF, Christenson RH, Nowak RM. Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction. Am J Emerg Med. 2021 Aug;46:170-175. doi: 10.1016/j.ajem.2020.06.072. Epub 2020 Jul 18. PMID: 33071083.
  4. Ward MD, Weber A, Merrill VD, Welch RD, Bazarian JJ, Christenson RH. Predictive Performance of Traumatic Brain Injury Biomarkers in High-Risk Elderly Patients. J Appl Lab Med. 2020 Jan 1;5(1):91-100. doi: 10.1093/jalm.2019.031393. Erratum in: J Appl Lab Med. 2020 May 1;5(3):608. doi: 10.1093/jalm/jfaa039. PMID: 32445344.
  5. Ibrahim NE, Afilalo M, Chen-Tournoux A, Christenson RH, Gaggin HK, Hollander JE, Kastner P, Levy PD, Mang A, Masson S, Nagurney JT, Nowak RM, Pang PS, Peacock WF, Dipl-Stat VR, Walters EL, Januzzi JL Jr. Diagnostic and Prognostic Utilities of Insulin-Like Growth Factor Binding Protein-7 in Patients With Dyspnea. JACC Heart Fail. 2020 May;8(5):415-422. doi: 10.1016/j.jchf.2020.02.009. PMID: 32354416.
  6. Giannitsis E, Blankenberg S, Christenson RH, Frey N, von Haehling S, Hamm CW, Inoue K, Katus HA, Lee CC, McCord J, Möckel M, Chieh JTW, Tubaro M, Wollert KC, Huber K. Critical appraisal of the 2020 ESC guideline recommendations on diagnosis and risk assessment in patients with suspected non-ST-segment elevation acute coronary syndrome. Clin Res Cardiol. 2021 Sep;110(9):1353-1368. doi: 10.1007/s00392-021-01821-2. Epub 2021 Feb 26. PMID: 33635437; PMCID: PMC8405476.
  7. Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction. Circulation. 2020 Oct 20;142(16):1532-1544. doi: 10.1161/CIRCULATIONAHA.120.046682. Epub 2020 Aug 21. PMID: 32820656.
  8. Ward MD, Weber A, Merrill VD, Welch RD, Bazarian JJ, Christenson RH. Predictive Performance of Traumatic Brain Injury Biomarkers in High-Risk Elderly Patients. J Appl Lab Med. 2020 May 1;5(3):608. doi: 10.1093/jalm/jfaa039. Erratum for: J Appl Lab Med. 2020 Jan 1;5(1):91-100. doi: 10.1093/jalm.2019.031393. PMID: 32445348.
  9. Coudray MS, Hansel S, Alesci S, Meyer WA 3rd, Christenson RH, Landry LG, Edwards C, Puckrein G, Forney DJ, Akinboboye O. Vitamin D Levels and SARS-CoV-2 Infection among Medically Underserved Populations in the Minority and Rural Coronavirus Insights Study. Viruses. 2024 Apr 19;16(4):639. doi: 10.3390/v16040639. PMID: 38675979; PMCID: PMC11053904.
  10. Kalayci A, Peacock WF, Nagurney JT, Hollander JE, Levy PD, Singer AJ, Shapiro NI, Cheng RK, Cannon CM, Blomkalns AL, Walters EL, Christenson RH, Chen-Tournoux A, Nowak RM, Lurie MD, Pang PS, Kastner P, Masson S, Gibson CM, Gaggin HK, Januzzi JL Jr. Echocardiographic assessment of insulin-like growth factor binding protein-7 and early identification of acute heart failure. ESC Heart Fail. 2020 Aug;7(4):1664-1675. doi: 10.1002/ehf2.12722. Epub 2020 May 14. PMID: 32406612; PMCID: PMC7373911.
  11. Juraschek SP, Kovell LC, Appel LJ, Miller ER 3rd, Sacks FM, Christenson RH, Rebuck H, Chang AR, Mukamal KJ. Associations Between Dietary Patterns and Subclinical Cardiac Injury: An Observational Analysis From the DASH Trial. Ann Intern Med. 2020 Jun 16;172(12):786-794. doi: 10.7326/M20-0336. Epub 2020 May 19. PMID: 32423348; PMCID: PMC7388686.
  12. Wu AHB, Kavsak PA, Aakre KM, Christenson RH, Greene DN, Apple FS, Peacock WF, Hollander JE, de Lemos JA, Morrow D, Januzzi J, Jaffe AS. Lot-to-Lot Variation for Commercial High-Sensitivity Cardiac Troponin: Can We Realistically Report Down to the Assay's Limit of Detection? Clin Chem. 2020 Sep 1;66(9):1146-1149. doi: 10.1093/clinchem/hvaa160. Erratum in: Clin Chem. 2020 Nov 1;66(11):1462. doi: 10.1093/clinchem/hvaa215. PMID: 32785711.
  13. Appel LJ, Michos ED, Mitchell CM, Blackford AL, Sternberg AL, Miller ER 3rd, Juraschek SP, Schrack JA, Szanton SL, Charleston J, Minotti M, Baksh SN, Christenson RH, Coresh J, Drye LT, Guralnik JM, Kalyani RR, Plante TB, Shade DM, Roth DL, Tonascia J; STURDY Collaborative Research Group. The Effects of Four Doses of Vitamin D Supplements on Falls in Older Adults : A Response-Adaptive, Randomized Clinical Trial. Ann Intern Med. 2021 Feb;174(2):145-156. doi: 10.7326/M20-3812. Epub 2020 Dec 8. PMID: 33284677; PMCID: PMC8240534.
  14. Nowak RM, Jacobsen G, Limkakeng A Jr, Peacock WF, Christenson RH, McCord J, Apple FS, Singer AJ, deFilippi CR. Outpatient versus observation/inpatient management of emergency department patients rapidly ruled-out for acute myocardial infarction: Findings from the HIGH-US study. Am Heart J. 2021 Jan;231:6-17. doi: 10.1016/j.ahj.2020.10.067. Epub 2020 Oct 28. PMID: 33127532.
  15. Stein NR, Zelnick LR, Anderson AH, Christenson RH, deFilippi CR, Deo R, Go AS, He J, Ky B, Lash JP, Seliger SL, Soliman EZ, Shlipak MG, Bansal N; CRIC Study Investigators. Associations Between Cardiac Biomarkers and Cardiac Structure and Function in CKD. Kidney Int Rep. 2020 May 7;5(7):1052-1060. doi: 10.1016/j.ekir.2020.04.031. PMID: 32647762; PMCID: PMC7335964.
  16. Plante TB, Gleason KT, Miller HN, Charleston J, McArthur K, Himmelfarb CD, Lazo M, Ford DE, Miller ER 3rd, Appel LJ, Juraschek SP; STURDY Collaborative Research Group. Recruitment of trial participants through electronic medical record patient portal messaging: A pilot study. Clin Trials. 2020 Feb;17(1):30-38. doi: 10.1177/1740774519873657. Epub 2019 Oct 3. PMID: 31581836; PMCID: PMC6992491.
  17. Oellerich M, Christenson RH, Beck J, Schütz E, Sherwood K, Price CP, Keown PA, Walson PD. Donor-Derived Cell-Free DNA Testing in Solid Organ Transplantation: A Value Proposition. J Appl Lab Med. 2020 Sep 1;5(5):993-1004. doi: 10.1093/jalm/jfaa062. PMID: 32447378.
  18. Christenson RH, Duh SH, Apple FA, Nowak R, Peacock WF, Limkakeng AT Jr, Bostanian Z, Mohammad A, McCord J, deFilippi CR. Pivotal findings for a high-sensitivity cardiac troponin assay: Results of the HIGH-US study. Clin Biochem. 2020 Apr;78:32-39. doi: 10.1016/j.clinbiochem.2019.10.013. Epub 2019 Oct 26. PMID: 31669511.
  19. Apple FS, Wu AHB, Sandoval Y, Sexter A, Love SA, Myers G, Schulz K, Duh SH, Christenson RH. Sex-Specific 99th Percentile Upper Reference Limits for High Sensitivity Cardiac Troponin Assays Derived Using a Universal Sample Bank. Clin Chem. 2020 Mar 1;66(3):434-444. doi: 10.1093/clinchem/hvz029. PMID: 32109298.
  20. Tummalapalli SL, Zelnick LR, Andersen AH, Christenson RH, deFilippi CR, Deo R, Go AS, He J, Ky B, Lash JP, Seliger SL, Soliman EZ, Shlipak MG, Bansal N; CRIC Study Investigators †. Association of Cardiac Biomarkers With the Kansas City Cardiomyopathy Questionnaire in Patients With Chronic Kidney Disease Without Heart Failure. J Am Heart Assoc. 2020 Jul 7;9(13):e014385. doi: 10.1161/JAHA.119.014385. Epub 2020 Jun 24. PMID: 32578483; PMCID: PMC7670503.
  21. Zhang YV, Kumanovics A, Wiencek J, Melanson SEF, Love T, Wu AHB, Zhao Z, Meng QH, Koch DD, Apple FS, Ondracek CR, Christenson RH. Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response. Viruses. 2024 Feb 14;16(2):292. doi: 10.3390/v16020292. PMID: 38400067; PMCID: PMC10891747.
  22. Nowak RM, Christenson RH, Jacobsen G, McCord J, Apple FS, Singer AJ, Limkakeng A Jr, Peacock WF, deFilippi CR. Performance of Novel High-Sensitivity Cardiac Troponin I Assays for 0/1-Hour and 0/2- to 3-Hour Evaluations for Acute Myocardial Infarction: Results From the HIGH-US Study. Ann Emerg Med. 2020 Jul;76(1):1-13. doi: 10.1016/j.annemergmed.2019.12.008. Epub 2020 Feb 8. PMID: 32046869.
  23. Christenson RH, Duh SH, Mullins KE, LeClair MM, Grigorov IL, Peacock WF. Analytical and clinical characterization of a novel high-sensitivity cardiac troponin assay in a United States population. Clin Biochem. 2020 Sep;83:28-36. doi: 10.1016/j.clinbiochem.2020.05.014. Epub 2020 May 30. PMID: 32485169.
  24. Kovell LC, Yeung EH, Miller ER 3rd, Appel LJ, Christenson RH, Rebuck H, Schulman SP, Juraschek SP. Healthy diet reduces markers of cardiac injury and inflammation regardless of macronutrients: Results from the OmniHeart trial. Int J Cardiol. 2020 Jan 15;299:282-288. doi: 10.1016/j.ijcard.2019.07.102. Epub 2019 Aug 2. PMID: 31447226; PMCID: PMC7172033.
  25. Michos ED, Mitchell CM, Miller ER 3rd, Sternberg AL, Juraschek SP, Schrack JA, Szanton SL, Walston JD, Kalyani RR, Plante TB, Christenson RH, Shade D, Tonascia J, Roth DL, Appel LJ; STURDY Collaborative Research Group. Corrigendum to "Rationale and design of the Study To Understand Fall Reduction and Vitamin D in You (STURDY): A randomized clinical trial of Vitamin D supplement doses for the prevention of falls in older adults" [Contemp Clin Trials. 73 (2018) 111-122]. Contemp Clin Trials. 2020 Mar;90:105936. doi: 10.1016/j.cct.2020.105936. Epub 2020 Jan 27. Erratum for: Contemp Clin Trials. 2018 Oct;73:111-122. doi: 10.1016/j.cct.2018.08.004. PMID: 32001213; PMCID: PMC7236292.
  26. Christenson RH. Out of the Darkness, Into the Light: Value of SARS-CoV-2 Antibody Testing in Populations to Benefit Public Health and in Individuals for Peace of Mind. J Appl Lab Med. 2020 Sep 1;5(5):1101-1106. doi: 10.1093/jalm/jfaa105. PMID: 32592490; PMCID: PMC7337836.

 

Christopher R. deFilippi, MD, MS

  1. Nowak RM, Christenson RH, Jacobsen G, McCord J, Apple FS, Limkakeng A, Peacock WF, deFilippi CR. Performance of Novel High-Sensitivity Cardiac Troponin I Assays for 0/1-Hour and 0/2–3-Hour Evaluations for Acute Myocardial Infarction: Results from the HIGH-US Study. Ann Emerg Med. 2020;76:1-13
  2. Shavadia JS, Granger CB, Alemayehu W, Westerhout CM, Povsic TJ, Brener SJ, Diepen SV, deFilippi C, Armstrong PW. High-throughput Targeted Proteomics Discovery Approach and Spontaneous Reperfusion in ST-segment Elevation Myocardial Infarction. Am Heart J. 2020;220:137-144
  3. Lewis AA, Ayers CR, Selvin E, Neeland I, Ballantyne C, Nambi V, Pandey A, Powell-Wiley TM, Drazner MH, Carnethon MR, Berry JD, Seliger SL, deFilippi CR, de Lemos JA. Racial Differences in Malignant Left Ventricular Hypertrophy and Incidence of Heart Failure: A Multi-Cohort Study. Circulation. 2020;141:957-967
  4. Christenson RH, Duh SH, Apple FA, Nowak R, Peacock WF, Limkakeng AT Jr, Bostanian Z, Mohammad A, McCord J, deFilippi CR. Pivotal Findings for a High-Sensitivity Cardiac Troponin Assay: Results of the HIGH-US Study. Clin Biochem.  2020;78:32-39.
  5. Nguyen K, Fan W, Bertoni A, Budoff MJ, deFilippi C, Lombardo D, Maisel A, Szklo M, Wong ND. N-terminal Pro B-type Natriuretic Peptide and High-sensitivity Cardiac Troponin as Markers for Heart Failure and Cardiovascular Disease Risks According to Glucose Status (from the Multi-Ethnic Study of Atherosclerosis [MESA]).  Am J Cardiol. 2020;125(8):1194-1201
  6. deFilippi C, Toribio M, Wong LP, Sadreyev R, Grundberg I, Fitch KV, Zanni MV, Lo J, Sponseller CA, Sprecher E, Rashidi N, Thompson MA, Cagliero D, Aberg JA, Braun LR, Stanley TL, Lee H, Grinspoon SK. Differential Plasma Protein Regulation and Statin Effects in HIV-infected and Non-HIV-infected Patients Utilizing a Proteomics Approach Protein Regulation and Statin Effects in HIV.  J Infect Dis. 2020;222:929-39
  7. Fitzgerald RL, Hollander JE, Peacock WF, Limkakeng AT, Breitenbeck N, Rivers EJ, Ziegler A, Laimighofer M, deFilippi C. The 99th percentile upper reference limit for the 5th generation cardiac troponin T assay in the United States.  Clin Chim Acta. 2020;504:172-179
  8. Shavadia JS, Granger CB, Alemayehu W, Westerhout CM, Povsic TJ, Van Diepen S, deFilippi C, Armstrong PW. Novel Biomarkers, ST-Elevation Resolution, and Clinical Outcomes Following Primary Percutaneous Coronary Intervention. J Am Heart Assoc. 2020;9(13):e016033. doi: 10.1161/JAHA.120.016033.
  9. Cooper LB, Psotka MA, Sinha S, Nallamothu BK, deFilippi CR, Batchelor W, O'Connor CM, Damluji AA. Specificity of administrative coding for older adults with acute heart failure hospitalizations. Am Heart J. 2020;223:1-2
  10. Gore MO, Ayers CR, Khera A, deFilippi CR, Wang TJ, Seliger SL, Nambi V, Selvin E, Berry JD, Hundley WG, Budoff M, Greenland P, Drazner MH, Ballantyne CM, Levine BD, de Lemos JA. Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults. J Am Heart Assoc. 2020;9(15):e015410. doi: 10.1161/JAHA.119.015410.
  11. Nowak RM, Peacock WF, deFilippi CR. In reply. Ann Emerg Med. 2020;76:692-93
  12. Horiuchi Y, Wettersten N, Patel MP, Mueller C, Neath SX, Christenson RH, Morgenthaler NG, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney JT, Schreiber D, deFilippi C, Hogan C, Diercks DB, Headden G, Limkakeng AT Jr, Anand I, Wu AHB, Ebmeyer S, Jaffe AS, Peacock WF, Maisel A. Biomarkers Enhance Discrimination and Prognosis of Type 2 Myocardial Infarction. Circulation. 2020;142:1532-44
  13. Stein NR, Zelnick LR, Anderson AH, Christenson RH, deFilippi CR, Deo R, Go AS, He J, Ky B, Lash JP, Seliger SL, Soliman EZ, Shlipak MG, Bansal N; CRIC Study Investigators. Associations Between Cardiac Biomarkers and Cardiac Structure and Function in CKD. Kidney Int Rep 2020;5:1052-1060
  14. Gibbs J, deFilippi C, Peacock F, Mahler S, Nowak R, Christenson R, Apple F, Jacobsen G, McCord J. The utility of risk scores when evaluating for acute myocardial infarction using high-sensitivity cardiac troponin I. Am Heart J. 2020;227:1-8
  15. Tummalapalli SL, Zelnick LR, Andersen AH, Christenson RH, deFilippi CR, Deo R, Go AS, He J, Ky B, Lash JP, Seliger SL, Soliman EZ, Shlipak MG, Bansal N; CRIC Study Investigators. Association of Cardiac Biomarkers With the Kansas City Cardiomyopathy Questionnaire in Patients With Chronic Kidney Disease Without Heart Failure. J Am Heart Assoc. 2020 Jul 7;9(13):e014385. doi: 10.1161/JAHA.119.014385
  16. Sbolli M, deFilippi C. BNP and NT-proBNP Interpretation in the Neprilysin Inhibitor Era. Curr Cardiol Rep. 2020;22:150 doi: 10.1007/s11886-020-01398-8
  17. Donthi N, Chandrabhatla T, Genovese L, deFilippi C. Fast and furious: flecainide toxicity presenting as monomorphic ventricular tachycardia [case report]. BMJ Case Rep. 2020;13:e236932. doi: 10.1136/bcr-2020-236932
  18. Suthahar N, Lau ES, Blaha MJ, Paniagua SM, Larson MG, Psaty BM, Benjamin EJ, Allison MA, Bartz TM, Januzzi JL Jr, Levy D, Meems LMG, Bakker SJL, Lima JAC, Cushman M, Lee DS, Wang TJ, deFilippi CR, Herrington DM, Nayor M, Vasan RS, Gardin JM, Kizer JR, Bertoni AG, Allen NB, Gansevoort RT, Shah SJ, Gottdiener JS, Ho JE, de Boer RA.Sex-Specific Associations of Cardiovascular Risk Factors and Biomarkers With Incident Heart Failure. J Am Coll Cardiol 2020;76:1455-65
  19. Gottdiener JS, Seliger S, deFilippi C, Christenson R, Baldridge AS, Kizer JR, Psaty BM, Shah SJ. Relation of Biomarkers of Cardiac Injury, Stress, and Fibrosis With Cardiac Mechanics in Patients ≥ 65 Years of Age. Am J Cardiol 2020;136:156-163