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Haseeb Zubair, PhD

Academic Title:

Assistant Professor

Primary Appointment:

Surgery

Email:

hzubair@som.umaryland.edu

Location:

670 W Baltimore Street

Phone (Primary):

410-706-3546

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Education and Training

2003-2006       B.Sc. Biochemistry, Aligarh Muslim University

2006-2008       M.Sc. Biochemistry, Aligarh Muslim University

2008-2012       Ph.D. Biochemistry, Aligarh Muslim University

2014-2020       Postdoctoral Fellow, University of South Alabama

2020-2021       Lead Researcher, 3D Genome Consortium, St. Jude Children's Research Hospital

Research/Clinical Keywords

Cancer: Molecular pathogenesis, tumor-stromal interaction, chemoresistance, Transplant: Operational Tolerance, ischemia-reperfusion injury, disease pathogenesis Overarching: single-cell/nuclei RNA sequencing, immunology, DNA methylation, epigenetics, genomics, non-invasive biomarkers

Highlighted Publications

Azim S, Zubair H, Rousselle T, McDaniels JM, Shetty AC, Kuscu C, Kuscu C, Talwar M, Eason, JD, Maluf DG, Mas VR. Single cell RNA sequencing reveals peripheral blood mononuclear immune  landscape associated with operational tolerance in a kidney transplant recipient. Am J Transplant. 2023 May 16;S1600-6135(23)00466-5. doi: 10.1016/j.ajt.2023.04.035. Online ahead of print.
Zubair H, Azim S, Maluf DG, Mas VR, Martins PN. Contribution of Proteomics in Transplantation: Identification of Injury and Rejection Markers. Transplantation. 2023 Feb 23;. doi: 10.1097/TP.0000000000004542. [Epub ahead of print] PubMed PMID: 36814094.
Hagiwara K, Natarajan S*, Wang Z*, Zubair H*, Mulder HL, Dong L, Plyler EM, Thimmaiah P, Ma X, Ness KK, Li Z, Mulrooney DA, Wilson CL, Yasui Y, Hudson MM, Easton J, Robison LL, Zhang J. Dynamics of Age- versus Therapy-Related Clonal Hematopoiesis in Long-term Survivors of Pediatric Cancer. Cancer Discov. 2023 Apr 3;13(4):844-857. doi: 10.1158/2159-8290.CD-22-0956. PubMed PMID: 36751942; PubMed Central PMCID: PMC10070170. *co-second author contribution
Zubair H, Khan MA, Anand S, Srivastava SK, Singh S, Singh AP. Modulation of the tumor microenvironment by natural agents: implications for cancer prevention and therapy. Semin Cancer Biol. 2022 May;80:237-255. doi: 10.1016/j.semcancer.2020.05.009. Epub 2020 May 26. Review. PubMed PMID: 32470379; PubMed Central PMCID: PMC7688484.
 
Srivastava SK, Khan MA, Anand S, Zubair H, Deshmukh SK, Patel GK, Singh S, Andrews J, Wang B, Carter JE, Singh AP. MYB interacts with androgen receptor, sustains its ligand-independent activation and promotes castration resistance in prostate cancer. Br J Cancer. 2022 May;126(8):1205-1214. doi: 10.1038/s41416-021-01641-1. Epub 2021 Nov 26. PubMed PMID: 34837075; PubMed Central PMCID: PMC9023474.
Acharya S, Anand S, Khan MA, Zubair H, Srivastava SK, Singh S, Singh AP. Biphasic transcriptional and post-transcriptional regulation of MYB by androgen signaling mediates its growth control in prostate cancer. J Biol Chem. 2022 Nov 18;:102725. doi: 10.1016/j.jbc.2022.102725. [Epub ahead of print] PubMed PMID: 36410437.
Deshmukh SK, Srivastava SK, Zubair H, Khan MA, Singh AP, Singh S. Resistin Induces LIN28A-Mediated Let-7a Repression in Breast Cancer Cells Leading to IL-6 and STAT3 Upregulation. Cancers (Basel). 2021 Sep 7;13(18). doi: 10.3390/cancers13184498. PubMed PMID: 34572725; PubMed Central PMCID: PMC8470467.
Zubair H, Patel GK, Khan MA, Azim S, Zubair A, Singh S, Srivastava SK, Singh AP. Proteomic Analysis of MYB-Regulated Secretome Identifies Functional Pathways and Biomarkers: Potential Pathobiological and Clinical Implications. J Proteome Res. 2020 Feb 7;19(2):794-804. doi: 10.1021/acs.jproteome.9b00641. Epub 2020 Jan 27. PubMed PMID: 31928012; PubMed Central PMCID: PMC7700759.
Zubair H, Azim S, Srivastava SK, Ahmad A, Bhardwaj A, Khan MA, Patel GK, Arora S, Carter JE, Singh S, Singh AP. Glucose Metabolism Reprogrammed by Overexpression of IKKε Promotes Pancreatic Tumor Growth. Cancer Res. 2016 Dec 15;76(24):7254-7264. doi: 10.1158/0008-5472.CAN-16-1666. Epub 2016 Oct 20. PubMed PMID: 27923829; PubMed Central PMCID: PMC5161695.
Patton MC, Zubair H, Khan MA, Singh S, Singh AP. Hypoxia alters the release and size distribution of extracellular vesicles in pancreatic cancer cells to support their adaptive survival. J Cell Biochem. 2020 Jan;121(1):828-839. doi: 10.1002/jcb.29328. Epub 2019 Aug 12. PubMed PMID: 31407387; PubMed Central PMCID: PMC6878126.

Awards and Affiliations

2012 Best Poster Award, Aligarh Muslim University, awarded for poster presentation at Silver Jubilee Symposium on Emerging Trends in Biochemical and Toxicological Sciences

2016 Young Investigator Award, American Pancreatic Association at APA Annual Conference in October, 2016

2017 Fellowship to attend the 5th Annual Workshop on Metabolomics, July 16-21, 2017 at University of Alabama, Birmingham sponsored by the National Institute of General Medical Sciences and Departments of Chemistry and Pharmacology and Toxicology at UAB

2023 Rising Star Award, The 2023 International Congress of ILTS, ELITA and LICAGE at Rotterdam, Netherlands.

2023 Travel Award, The American Transplant Congress, awarded by the Liver-Intestine Community of Practice for Oral Presentation at ATC 2023

Grants and Contracts

ACS-IRG

NSRP

Professional Activity

2016 Designer, Pamphlets for Pancreatic Cancer Awareness at USA Mitchell Cancer Institute

2017 Judge, Poster Session (Graduate and Undergraduate students), NanoBio Summit 2017, USA Mitchell Cancer Institute

2018, 2019 Judge, USA Mitchell Cancer Institute paid-internship oral presentation

2019-2020 Co-organizer, Pancreatic Cancer Research Forum at USA Mitchell Cancer Institute

2022 Judge, Poster Session, 12th Annual Cancer Biology Research Retreat, University of Maryland Baltimore

2022-2025: Sterling Committee Member- Special Interest Group: Precision Medicine and Biomarkers in Liver Transplantation, International Liver Transplantation Society

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