Obstetrics, Gynecology and Reproductive Sciences
Bressler Research Building, 11-041
Education and Training
1982 B.Sc. in Biology, Dalian Fisheries College (Dalian Ocean University), Dalian, China
1985 M.Sc. in Zoology, South China Normal University, Guangzhou, China
1993 Ph.D. in Developmental Biology, University of Manchester, Manchester, England
1997 Postdoctoral Associate, Pennsylvania State University, University Park, PA
2000 Postdoctoral Associate, Yale University School of Medicine, New Haven, CT
Prior to joining the faculty of the University of Maryland School of Medicine, Dr. Zhao was an associate research scientist in the Department of Pediatrics at Yale University School of Medicine from 2000 to 2004 and assistant professor in the Department of Obstetrics and Gynecology at University of Arkansas for Medical Sciences from 2004 to 2006.
Cardiovascular development, birth defects, diabetic embryopathy, neural tube defects, heart defects, programmed cell death, adenosine receptor, GTPase, ROCK, phospholipid metabolism, intracellular calcium, endoplasmic reticulum stress, nitrosative stress, mitochondrion, protein folding, protein aggregation, phytochemicals
Zhao Z, Cao L, Reece EA. (2017) Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects. Proc Natl Acad Sci U S A; 114:4489-94.
Cao L, Tan C, Meng F, Liu P, Reece EA, Zhao Z. (2016) Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin. Sci Rep; 6:21491.
Cao L, Liu P, Gill K, Reece EA, Cheema AK, Zhao Z. (2016) Identification of novel cell survival regulation in diabetic embryopathy via phospholipidomic profiling. Biochem Biophys Res Commun; 470:599-605.
Zhao Z, Eckert RL, Reece EA. (2012) Reduction in embryonic malformations and alleviation of endoplasmic reticulum stress by nitric oxide synthase inhibition in diabetic embryopathy. Reprod Sci; 19:823-31.
Zhao Z. (2012) Endoplasmic reticulum stress in maternal diabetes-induced cardiac malformations during critical cardiogenesis period. Birth Defects Res B Dev Reprod Toxicol; 95:1-6.
Zhao Z. (2010) Cardiac malformations and alteration of TGFβ signaling system in diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol; 89:97-105.
Zhao Z, Yang P, Eckert RL, Reece EA. (2009) Caspase-8: a key role in the pathogenesis of diabetic embryopathy. Birth Defects Res B Dev Reprod Toxicol; 86:72-7.
Zhao Z, Rivkees SA. (2004) Rho-associated kinases play a role in endocardial cell differentiation and migration. Dev Biol; 275:183-91.
Zhao Z, Rivkees SA. (2003) Rho-associated kinases play an essential role in cardiac morphogenesis and cardiomyocyte proliferation. Dev Dyn; 226:24-32.
Zhao Z, Rivkees SA. (2000) Programmed cell death in the developing heart: regulation by BMP4 and FGF2. Dev Dyn; 217:388-400.
2001 Young Investigator Award, the Eastern Society for Pediatric Research
2007 CDC’s Special Emphasis Panel on "Scientific, Technical and Operational Services for Epidemiology, Surveillance and Laboratory Programs”
2012 Ad-hoc member of NIH Pregnancy and Neonatology (PN) study section
2012 NIH EMNR Special Review Panel
2013 Grant reviewer, The Israel Science Foundation
2013 Ad-hoc member of NIH Pregnancy and Neonatology (PN) study section
2014 NIH EMNR Special Review Panel
2014 Grant reviewer, Czech Science Foundation
2016/7 NIH Special Review Panel
2016/11 NIH Special Review Panel
2017/3 NIH Special Review Panel
2017 Ad-hoc member of NIH Cardiovascular Differentiation and Development (CDD) study section
2017 Grant reviewer, Health and Medical Research Fund, The Government of Hong Kong
2012- Editorial Board, Journal of Biomolecular Research and Therapeutics
2013- Editorial Board, Journal of Biochemistry & Molecular Biology
NIH R01HD076245 Zhao (PI) 7/16/2013-4/30/2018
Protein Modifications and Unfolded Protein Response in Diabetic Embryopathy.
NIH R03HD075995 Zhao (PI) 7/14/2014-6/30/2016
Targeting Nitrosative Stress to Prevent Fetal Anomalies in Diabetic Embryopathy.
NIH 3R01HD076245-03S1 Zhao (PI) 5/1/2015-4/30/2016
Impact of sex of embryo on morphogenesis and therapy in diabetic pregnancy.