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Nagendra Yadava, PhD

Academic Title:

Visiting Assistant Professor

Primary Appointment:

Anesthesiology

Location:

MSTF, 5-34

Phone (Primary):

(410) 706-3418

Fax:

(410) 328-5531

Education and Training

1986-1989            B.Sc. (Hons.), Botany (Honors), Chemistry, Zoology

                                 Banaras Hindu University, Varanasi, Uttar Pradesh, India

1989-1991            M.Sc., Biotechnology, Maharaja Sayajirao University of Baroda, Vadodara,

                                 Gujrat, India

1991-1998            Ph.D., Life Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India

1997-1998            Research Fellow; The Chicago Medical School, North Chicago, Illinois, USA      

1998-2003            Post-Graduate Research Biologist; Division of Biological Sciences, University

                                 of California San Diego, La Jolla, California, USA

     

 

Highlighted Publications

  1. Jasrai Y., Yadava N., Mehta A.R. Somatic embryogenesis from leaf induced cell cultures of Plantago ovata J. Herbs, Spices and Med. Plants, 1(4): 11-16 (1993).
  2. Yadava N., Chandok M.R., Prasad J., Bhattacharya S., Sopory S.K., Bhattacharya, A. Characterization of EhCaBP, a calcium-binding protein of Entamoeba histolytica and its binding proteins. Mol. Biochem. Parasitol., 84(1): 69-82; PMID: 9041522 (1997).
  3. Bhattacharya A., Anand M.T., Paul J., Yadav N., Bhattacharya S. Molecular changes in Entamoeba histolytica in response to bacteria. J. Euk. Microbiol., 45(2S): 28-33; PMID: 9561781 (1998).
  4. Chen D.Q., Kolli B.K., Yadava N., Lu H.G., Gilman-Sachs A., Peterson D.A., Chang K.P. Episomal expression of specific sense and antisense mRNAs in Leishmania amazonensis: modulation of gp63 level in promastigotes and their infection of macrophages in vitro. Infect. Immun., 68(1): 80-86; PMID: 10603371 (2000).
  5. Deswal R., Pandey G.K., Chandok M.R., Yadav N., Bhattacharya A., Sopory S.K. A novel protein kinase from Brassica juncea stimulated by a protozoan calcium-binding protein: Purification and partial characterization. Eur. J. Biochem., 267(11): 3181-3189; PMID: 10603371 (2000).
  6. Nelson M.K., Clark A., Abe T., Nomura A., Yadava N., Funair C.J., Jermyn K.A., Mohanty S., Firtel R.A., Williams J.G. An F-Box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behavior, and culmination. Dev. Biol., 224: 42-59; PMID: 10898960 (2000).
  7. Sahoo N., Chakrabarty P., Yadava N., Bhattacharya S., Bhattacharya A. Calcium-binding protein of Entamoeba histolytica. Arch. Med. Res., 31(4S): 57-59; PMID: 11070223 (2000).
  8. Mohanty S., Lee S., Yadava N., Dealy M.J., Johnson R.S., Firtel R.A. Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium. Genes & Dev., 15(11): 1435-1448; PMID: 11390363 (2001).
  9. Scheffler I.E., Yadava N. Molecular genetics of the mammalian NADH-ubiquinone oxidoreductase. J. Bioenerg. Biomembr., 33(3): 243-250; PMID: 11695834 (2001).
  10. Yadava N., Potluri P., Smith E., Bisevac A., Scheffler I. E. Species-specific and mutant MWFE proteins: their effect on the assembly of the mammalian mitochondrial complex I. J. Biol. Chem., 277(24):21221-21230. Additions and Corrections: 277 (45), 43544; PMID: 11937507 (2002)
  11. Scheffler I.E., Yadava N., Potluri P. Molecular genetics of complex I-deficient Chinese hamster cell lines. Biochim. Biophys. Acta, 1659:160-171; PMID: 15576048 (2004).
  12. Yadava N., Houchens T., Potluri P., Scheffler I.E. Development and characterization of a conditional mitochondrial complex I assembly system. J. Biol. Chem., 279(13): 12406-12413; PMID: 14722084 (2004).
  13. Yadava N., Scheffler I.E. Import and orientation of the MWFE protein in mitochondrial NADH-ubiquinone oxidoreductase. Mitochondrion, 4: 1-12; PMID: 16120368 (2004).
  14. Ricci J.E., Munoz-Pinedo C., Fitzerald P., Bailly-Maitre B., Perkins G.A., Yadava N., Scheffler I.E., Ellisman M.H., Green D.R. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit (NDUFS1) of complex I of the electron transport chain. Cell, 117: 773-786; PMID: 15186778 (2004).
  15. Potluri P., Yadava N., Scheffler I.E. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Eur. J. Biochem., 271: 3265-3273; PMID: 15265046 (2004).
  16. Mamelak A.J., Kwalski J., Murphy K., Yadava N., Zhurak M., Kouba D.J., Howell, B.G., Tzu J., Cummins D.L., Liegeois N.J., Berg K., Sauder D.N. Downregulation of NDUFA1 and the oxidative phosphorylation-related genes is a consistent feature of basal cell carcinoma. Exp. Dermatol., 14(5): 336-348; PMID: 15854127 (2005).
  17. Yadava N., Nicholls D.G. Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity following partial respiratory inhibition of mitochondrial complex I with rotenone. J Neurosci., 27(27): 7310-7317; PMID: 17455297 (2007).
  18. Nicholls D.G., Johnson-Cadwell L., Vesce S., Jekabsons M., Yadava N. Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. J Neurosci. Res., 85(15): 3206-3212; PMID: 17611283 (2007).
  19. Yadava N., Potluri P., Scheffler I.E. Investigations of the potential effects of phosphorylation of the MWFE and ESSS subunits on complex I activity and assembly. Int. J. Biochem. Cell Biol., 40(3): 447-460; PMID: 17931954 (2008).
  20. Amo T., Yadava N., Oh R., Nicholls D.G., Brand M.D. Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene, 411(1-2):69-76; PMID: 18280061 (2008).
  21. Chinta SJ., Rane A., Yadava N., Andersen J.K., Nicholls D.G., Polster, BM. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Rad. Biol. Med., 46(7):939-47; PMID: 19280713 (2009).
  22. Gerencser A.A., Neilson A., Choi S.W., Edman U., Yadava N., Oh R.J., Ferrick D.A., Nicholls D.G., Brand MD. Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem., 81: 6868-6878; PMID: 19555051 (2009).
  23. Compton C., Kim C., Griner N.B., Potluri P., Scheffler I.E., Sen S., Jerry D.J., Schneider S., Yadava N. Mitochondrial dysfunction impairs tumor suppressor p53 expression/function. J. Biol. Chem., 286(23): 20297-20312; PMID: 21502317 (2011).
  24. Yadava N., Schneider S., Jerry D.J., Kim C., Impaired mitochondrial metabolism and mammary carcinogenesis. J. Mammary Gland Biol. 18:75-87; PMID: 23269521 (2013).
  25. Divakaruni A.S., Wiley S.E., Rogers G.W., Andreyev A.Y., Petrosyan S., Loviscach M., Wall E.A., Yadava N., Heuck A.P., Ferrick D.A., Henry R.R., McDonald W.G., Colca J.R., Simon M.I., Ciaraldi T.P., Murphy A.N. Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier. Proc. Natl. Acad. Sci., 110(14):5422-5427; PMID: 23513224 (2013).
  26. Kim C., Patel P., Gouvin, L.M., Brown, M.L., Khalil, A., Henchey, E.M., Heuck A.P., Yadava N. Comparative analysis of the mitochondrial physiology of pancreatic cells. Bioenergetics, 3(1):110; doi:10.4172/2167-7662.1000110; PMID: 25309834 (2014).
  27. Quinlan C.L., Goncalves R.L.S., Hey-Mogensen M., Yadava N., Bunik V.I., Brand M.D.: The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J. Biol. Chem. 289:8312-8325; PMID: 24515115 (2014).
  28. Yadav N., Kumar S., Marlowe T., Chaudhary A.K., Kumar R., Wang J., O’Malley J., Boland P., Jayanthi S., Kumar T.K.S., Yadava N., Chandra D. Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents. Cell Death & Dis. 6: e1969. doi: 10.1038/cddis.2015.305; PMID: 26539916 (2015).
  29. Sen S., Domingues C.C., Rouphael R., Chou C., Kim C., Yadava N. Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improves glucose tolerance test in an obese diabetic mouse model. Stem Cell Res. Ther. 6:242. doi: 10.1186/s13287-015-0224-9; PMID: 26652025 (2015).
  30. Yadav N., Kumar S., Kumar R., Srivastava P., Sun L., Rapali P., Marlowe T., Schneider A., Inigo J., O’Malley J., Londonkar R., Gogada R., Chaudhary A., Yadava N., Chandra D. Mechanism of neem limonoids-induced cell death in cancer: role of oxidative phosphorylation. Free Rad. Biol. Med. 90:261-271; PMID: 26627937 (2016).
  31. Bordt E.A., Clerc P., Roelofs B.A., Saladino A.J., Tretter L., Adam-Vizi V., Cherok E., Khalil A., Yadava N., Ge S.X., Francis T.C., Kennedy N.W., Picton L.K., Kumar T., Uppuluri S., Miller A., Karbowski M., Sesaki H., Hill R.B., Polster B.M. The putative Drp1 inhibitor mdivi-1 is a reversible complex I inhibitor that modulates reactive oxygen species. Dev Cell. 40(6):583-594.e6. doi: 10.1016/j.devcel.2017.02.020. PMID: 28350990 (2017).
  32. Schneider S.S., Henchey E.M., Sultana S., Morin S.M., Jerry D.J., Makari-Judson G., Crisi G.M., Arenas R.B., Johnson M., Mason H.S., Yadava N. Individual-specific variation in the respiratory activities of HMECs and their bioenergetic response to IGF1 and TNFα. J Cell Physiol. 232:2750–2765. PMID: 28369883 (2017).
  33. Kim C., Potluri P., Khalil A., Gaut D., McManus, M.J, Compton S., Wallace D.C., Yadava, N. An X-chromosome linked mouse model (Ndufa1S55A) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases. Neurochem. Int. 109:78-93; PMID: 28506826 (2017)
  34. Wong K.E., Mora M.C., Sultana N., Moriarty K.P., Arenas R.B., Yadava N., Schneider S.S., Tirabassi M.V. Evaluation of Rhodiola crenulata on growth and metabolism of NB-1691, a MYCN amplified neuroblastoma cell line. Tumor Biol. 40(6):1010428318779515. doi: 10.1177/1010428318779515. PMID: 29871587 (2018).
  35. Ozay E.I., Sherman H.L., Mello V., Trombley G., Lerman A., Tew G.N., Yadava N., Minter L.M. Rotenone treatment reveals a role for electron transport Complex I in the subcellular localization of key transcriptional regulators during T helper cell differentiation. Front Immunol. 9:1284. doi: 10.3389/fimmu.2018.01284. PMID: 29930555 (2018).