Education and Training
B.S., Seoul National University, Seoul Korea. Zoology
M.S., Seoul National University, Seoul Korea. Zoology
Ph.D., Seoul National University, Seoul Korea. Molecular Biology
Dr. Woo is a research scientist in the fields of molecular biology and protein biochemistry. He is responsible for the molecular identification of the Sur1-Trpm4 channel that plays a key role in oncotic cell death following various forms of CNS injury such as stroke and spinal cord injury. His research goal is to elucidate activation mechanism of the channel. That includes (1) identification of cis-regulatory elements and trans-acting factors involved in transcriptional stimulation of the Abcc8/Sur1 and Trpm4 genes following ischemic and traumatic CNS injury, and (2) studying post-translational regulatory mechanism including physical interaction between the two subunits and trafficking to plasma membrane.
Sur1-Trpm4 channel; transcriptional regulation; post-translational modification; protein interaction; stroke; spinal cord injury; CNS injury
Woo SK, Kwon MS, Ivanov A, Geng Z, Gerzanich V, and Simard JM. (2013) Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b. J Biol Chem. 288(51):36409 - 36417. doi: 10.1074/jbc.M113.530584.
Woo SK, Kwon MS, Ivanov A, Gerzanich V, and Simard JM. (2013) The Sulfonylurea Receptor 1 (Sur1) - Transient Receptor Potential Melastatin 4 (Trpm4) Channel. J Biol Chem. 288(5):3655 - 3667. doi: 10.1074/jbc.M112.428219.
Woo SK, Kwon MS, Geng Z, Chen Z, Ivanov A, Bhatta S, Gerzanich V, Simard JM. (2011) Sequential activation of hypoxia-inducible factor 1 and specificity protein 1 is required for hypoxia-induced transcriptional stimulation of Abcc8. J Cereb Blood Flow Metab. doi: 10.1038/jcbfm.2011.159.
Simard JM, Woo SK, Norenberg MD, Tosun C, Chen Z, Ivanova S, Tsymbalyuk O, Bryan J, Landsman D, and Gerzanich V. (2010) Brief suppression of Abcc8 prevents autodestruction of spinal cord after trauma. Sci Transl Med. 2: 28ra29.
Gerzanich V, Woo SK, Vennekens R, Tsymbalyuk O, Ivanova S, Ivanov A, Geng Z, Chen Z, Nilius B, Flockerzi V, Freichel M, and Simard JM. (2009) De novo expression of TRPM4 initiates secondary hemorrhage in spinal cord injury. Nat. Med. 15:185 – 191.
Additional Publication Citations
A complete list of published work in my bibliography may be found at:
http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/43648892/?sort=date&direction=ascending D. Research Support