Skip to main content

Xiaowei Wang, PhD

Academic Title:

Research Associate

Primary Appointment:

Microbiology and Immunology

Location:

685 W. Baltimore St, Baltimore, MD 21230

Phone (Primary):

410-706-3115

Education and Training

Ph.D. in Microbiology at the Institute of Microbiology of Chinese Academy of Sciences, Beijing, China.

Biosketch

Dr. Wang's research interests in the field of microbiology and immunology, especially in the area of host and bacterial pathogens interaction. His current study focuses on host innate immunity and inflammasome biology associated with bacterial pathogenesis. 

Research/Clinical Keywords

Pathogens, infection and immunity, inflammation, immune signaling, and inflammasomes.

Highlighted Publications

p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularis. McClure Carroll EE, Wang X, Shaw DK, O'Neal AJ, Oliva Chávez AS, Brown LJ, Boradia VM, Hammond HL, Pedra JHF. Proc Natl Acad Sci U S A. 2018 Dec 17. doi: 10.1073/pnas.1808905116.

Infection-derived lipids elicit an immune deficiency circuit in arthropods. Shaw DK, Wang X, Brown LJ, Chávez AS, Reif KE, Smith AA, Scott AJ, McClure EE, Boradia VM, Hammond HL, Sundberg EJ, Snyder GA, Liu L, DePonte K, Villar M, Ueti MW, de la Fuente J, Ernst RK, Pal U, Fikrig E, Pedra JH. Nature Communications 2017. 8:14401. doi: 10.1038/ncomms14401.

Deviant behavior: Tick-borne pathogens and inflammasome signaling. Shaw DK, McClure EE, Wang X, Pedra JHF. Vet Sci. 2016 Sep 28;3(4). doi: 10.3390/vetsci3040027.

The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. Wang X, Shaw DK, Hammond HL, Sutterwala FS, Rayamajhi M, Shirey KA, Perkins DJ, Bonventre JV, Velayutham TS, Evans SM, Rodino KG, VieBrock L, Scanlon KM, Carbonetti NH, Carlyon JA, Miao EA, McBride JW, Kotsyfakis M, Pedra JH. The prostaglandin E2-EP3 receptor axis regulates Anaplasma phagocytophilum-mediated NLRC4 inflammasome activation. PLoS Pathog. 2016 Aug 2;12(8):e1005803. doi:10.1371/journal.ppat.1005803. PMID:27482714.

The tick protein sialostatin L2 binds to Annexin A2 and inhibits NLRC4-mediated inflammasome activation. Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JH. (2016) Infect Immun. 2016 May 24;84(6):1796-805. doi: 10.1128/IAI.01526-15.

The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection. Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH. (2014) Infect Immun. 2014 82(6):2553-64. doi: 10.1128/IAI.01679-14.