Assistant Professor Division of Vascular Surgery Department of Surgery
Education and Training
Fellowship - Vascular Surgery; University of Pittsburgh Medical Center; Pittsburgh, PA
Residency - General Surgery;Loyola University Medical Center; Maywood,IL
Loyola University Chicago; Maywood, IL
Ph.D.; Cell Biology, Neurobiology, and Anatomy
Tufts University School of Medicine; Boston, MA
Cornell University, Arts and Sciences; Ithaca, NY
B.A.; Cell/Molecular Biology
Dr. Ucuzian is a vascular surgeon and scientist, Assistant Professor of Surgery at the University of Maryland School of Medicine, and staff surgeon at the Baltimore Veterans Administration Medical Center. He received his Bachelor of Arts at Cornell University, his Medical Degree at Tufts University, and his PhD from Loyola University Chicago. He completed general and vascular surgery training at Loyola University Medical Center and the University of Pittsburgh Medical Center, respectively. He received the Robert W. Hobson, II, MD Early Career Investigator Award from the Council on Peripheral Vascular Disease of the American Heart Association. He is funded by an NIH K08 and SVS Foundation/American College of Surgeons Mentored Clinical Scientist Research Career Development Award. His research focuses on the molecular dysregulation associated with thoracic aortic dissection and aneurysm formation (TAAD), and the effect of exercise in modulating TAAD pathogenesis and patient quality of life.
Aortic Disease Carotid Artery Disease Diabetic Foot Wounds Dialysis Access Surgery Limb Preservation Venous Disease
- Pang Y, Wang X, Ucuzian AA, Brey EM, Burgess WH, Jones KJ, Alexander TD, Greisler HP. “Local Delivery of a Collagen-binding FGF-1 Chimera to Smooth Muscle Cells in Collagen Scaffolds for Vascular Tissue Engineering.” Biomaterials. 2010 Feb; 31(5): 878-885.
- Ucuzian AA, Brewster LP, East AT, Pang Y, Gassman AA, Greisler HP. “Characterization of the Chemotactic and Mitogenic Response of SMCs to PDGF-BB and FGF-2 in Fibrin Hydrogels.” J Biomed Mater Res A. 2010 Sep; 94(3): 988-996.
- Brewster LP, Ucuzian AA, Brey EM, Liwanag M, Samarel AM, Greisler HP. “FRNK Overexpression Limits the Depth and Frequency Of Vascular Smooth Muscle Cell Invasion in a Three-Dimensional Fibrin Matrix.” J Cell 2010 Nov; 225(2): 562-568.
- Gassman AA, Kuprys T, Ucuzian AA, Brey E, Matsumura A, Pang Y, Larson J, Greisler HP. “Three Dimensional 10% Cyclic Strain Reduces Bovine Aortic Endothelial Cell Angiogenic Sprout Length and Augments Tubulogenesis in Tubular Fibrin Hydrogels.” J Tissue Eng Regen Med. 2011 May; 5(5): 375-383.
- Ucuzian AA, Bufalino DV, Pang Y, Greisler HP. “Angiogenic Endothelial Cell Invasion into Fibrin is Stimulated by Proliferating Smooth Muscle Cell.” Microvascular Research. Nov 22; 90:40-7. Epub 2013 Jul 22.
- Aicher BO, Mukhopadhyay S, Lu X, Muratoglu SC, Strickland DK, Ucuzian AA. “Quantitative micro-CT analysis of aortopathy in a mouse model of β-aminoproprionitrile-induced aortic aneurysm and dissection.” Journal of Visual Experimentation. 2018 Jul 16;(137).
- Farivar BS, Toursavadkohi S, Monahan TS, Sharma J, Ucuzian AA, Kundi R, Sarkar R, Lal BK. “Prospective study of cryopreserved placental tissue wound matrix in the management of chronic venous leg ulcers.” J Vasc Surg Venous Lymphat Disord. 2019 Jan 6.
- Yu D, Gernapudi R, Drucker C, Sarkar R, Ucuzian A, Monahan TS. “The myristoylated alanine-rich C kinase substrate differentially regulates kinase interacting with stathmin in vascular smooth muscle and endothelial cells and potentiates intimal hyperplasia formation.” J Vasc Surg. 2019 Mar 28.[Epub ahead of print]
- Hosseini M, Sahajwani S, Zhang J, Toursavadkohi S, Ucuzian AA. Delayed stroke after hospitalization for COVID-19 pneumonia from common and internal carotid artery thrombosis. Journal of Vascular Surgery Cases and Innovative Techniques. 2020 Nov 10.
- Aicher BO, Zhang J, Muratoglu S, Galisteo R, Arai AL, Gray VL, Lal BK, Strickland DK, Ucuzian AA. Moderate Aerobic Exercise Prevents Matrix Degradation and Death in a Mouse Model of Aortic Dissection and Aneurysm. American Journal of Physiology-Heart and Circulatory Physiology. 2021 Feb 26.
My prior research work focused on vascular tissue engineering, and the study of growth factors as tools for the engineering of micro-vasculatures in tissue engineered blood vessels. Since accepting a faculty position at the University of Maryland School of Medicine, I have worked with Dr. Dudley Strickland, to investigate the role of LRP1 in vascular disease. My current project builds on my experience in growth factors and vascular disease focusing on the molecular mechanisms underlying the pathogenesis of aortic dissection and aneurysm. We study this using both animal models and studies with human subjects. We have identified in animal models that aerobic exercise has a profoundly beneficial effect in aortic dissection. Mechanistic studies are underway. I currently have ongoing clinical research projects and am the site Principal Investigator for a national randomized control trial BEST-CLI, comparing endovascular and open surgery in critical limb ischemia. Additionally, I am the princial investigator of a quality of life assessment of patients with chronic aortic dissections and am preparing a human subject trial evaluating physical activity and exercise in aortic dissection.
My clinical interests include the broad spectrum of vascular disease including open and endovascular treatments for peripheral arterial disease, venous disease, carotid disease, dialysis access, and aortic disease.
Heart and Vascular Surgical Services, Vascular Surgery
Vascular Surgery - Board Certified
Highlighted Honors and Awards
2004 Alpha Omega Alpha Medical Honor Society, Tufts University School of Medicine
2007 Best Basic Science Paper Presentation, 31st Annual Meeting of the Association of VA Surgeons, Little Rock, AR
2017 Recipient, Robert W. Hobson, II, MD Early Career Investigator Award, Council of Peripheral Vascular Disease, American Heart Association
12/10/2019- PI (75% Effort)
11/30/2024 “Mechanisms of aortopathy in LRP1 deficiency.”
05/05/2018-Present Site PI
“Best Endovascular vs. Best Surgical Therapy in Patients with Critical Limb Ischemia (BEST-CLI)”
06/01/2020-05/31/2025 PI (75% Effort)
“Mechanisms of aortopathy in LRP1 deficiency.”
2020 SVS Foundation/American College of Surgeons Mentored Clinical Scientist Research Career Development Award
'Double Whammy' Abdominal Aortic Aneurysm and Heart Attack
2004-2013 Member, American College of Surgeons Candidate Group
2007-2008 Member, North American Vascular Biology Organization Trainee Group
2008-2009 Candidate Member, Peripheral Vascular Surgery Society
2017-Current Early Career Member, American Heart Association, PVD Council
2017-Current Member, Eastern Vascular Society
2018-Current Member; Fellow of the Society for Vascular Surgery, Society for Vascular Surgery
2018-Current Member, Vascular and Endovascular Surgery Society
2018-2019 Physician Member – National, American Venous Forum
2018-Current Member, Associate Fellow, American College of Surgeons
2018-Current Member, Association of VA Surgeons