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Van-Khue T. Ton, MD

Academic Title:

Assistant Professor

Primary Appointment:


Additional Title:

Advanced Heart Failure-Mechanical Circulatory Support-Heart Transplant


Baltimore, MD 21201

Phone (Primary):


Phone (Secondary):




Education and Training


  • 1998          A.A. Health Sciences – North Shore Community College

  • 2000          B.A. Biochemistry – Mount Holyoke College

  • 2005          Ph.D. Biochemistry – Johns Hopkins University School of Medicine

  • 2009          M.D. – Dartmouth Medical School

Post Graduate Education and Training

  • 2009-12     Internal Medicine Residency, Massachusetts General Hospital

  • 2012-15     Cardiology Fellowship, Johns Hopkins Hospital

  • 2015-16     Advanced Heart Failure-Transplant Fellowship, Columbia University


Dr. Van-Khue Ton is an Assistant Professor of Medicine in the Division of Cardiovascular Medicine, Advanced Heart Failure at the University of Maryland, School of Medicine. She came to the United States in 1996 after finishing high school in Vietnam. She graduated as a valedictorian from North Shore Community College, MA, then magna cum laude from Mount Holyoke College, MA. She obtained a Ph.D in Biochemistry at Johns Hopkins University School of Medicine in 2005 with a dissertation on the molecular basis of intracellular calcium regulation. She completed her medical training in 2009 at Dartmouth Medical School, NH, followed by Internal Medicine residency in 2012 at Massachusetts General Hospital, MA. She returned to Baltimore for a Cardiovascular Disease Fellowship at Johns Hopkins University School of Medicine (2012-2015). She also completed an Advanced Heart Failure Fellowship at Columbia University, NY in 7/2016. Dr. Ton joined the University of Maryland faculty in 8/2016.  

Her clinical interests are in the field of cardiomyopathy and advanced heart failure. She is passionate about taking care of patients with end-staged heart failure needing mechanical circulatory support and/or heart transplantation. Dr. Ton’s past research interest focused on cardiac amyloidosis, and she is looking to discover more research opportunities in the field of ventricular assist devices (VAD). Her research has been published in The Journal of Heart and Lung Transplantation, Clinical Cardiology and The Journal of Biological Chemistry.

Research/Clinical Keywords

Ventricular assist devices, advanced heart failure

Highlighted Publications

Ton VK, Mandal D, Vahadj C and Rao R (2002) Functional expression in yeast of the human secretory pathway calcium / manganese ATPase (hSPCA1) defective in Hailey Hailey disease. J. Biol. Chem. 277, 6422-7

Gupta SS, Ton VK, Beaudry Vet al. (2003) Amiodarone is a novel fungicide that triggers cytoplasmic calcium entry in S. cerevisiae. J. Biol. Chem. 278, 28831-9 (co-first author)

Ton VK and Rao R (2004) Functional expression of heterologous proteins in yeast. Insights into calcium signaling and calcium-transporting ATPases. Am. J. Physiol. Cell Physiol. 287, C580-9

Ton VK and Rao R (2004) Expression of Hailey-Hailey disease mutations in yeast. J. Invest. Dermatol. 123, 1192-4

Ton VK, Martin SS, Blumenthal RS and Blaha MJ(2012) Comparing the new European cardiovascular disease prevention guideline with prior American Heart Association guidelines: An editorial review. Clin Cardiol. 36(5), E1-6

Hsu S, Ton VK, Dominique Ashen Met al. (2013) A clinician’s guide to the ABCs of cardiovascular disease prevention: The Johns Hopkins Ciccarone Center for the prevention of heart disease and ACC Cardiosource approach to The Million Hearts Initiative. Clin Cardiol. 36(7), 383-93

Gilstrap L, Niehaus E, Maholtra R, Ton VK et al. (2014) Predictors of survival to orthotopic heart transplant in patients with immunoglobulin light chain amyloid cardiomyopathy. J Heart Lung Transplant. 33(2), 149-56

Ton VK, Mukherjee M and Judge DP (2015) Transthyretin cardiac amyloidosis: pathogenesis, treatments, and emerging role in heart failure with preserved ejection fraction. Clin Med Insights Cardiol. 8(Suppl 1), 39-44

Mukherjee M, Chung SE, Ton VKet al. (2016) Unique abnormalities in right ventricular longitudinal strain in systemic sclerosis patients. Circ CV Imaging. 9(6), pii: e003792

Ton VK, Garan AR, Takeda K, et al. (2016) LVAD implantation following repair of acute post myocardial infarction ventricular septal defect. J Card Surg. 31(10), 658-659

Ton VK, Vunjak-Novakovic G, Topkara VK. (2016) Transcriptional patterns of reverse remodeling with left ventricular assist devices: a consistent signature. Expert Rev Med Devices. 13(11), 1029-1034

Ton VK, Eisenberger A, Jennings D et al. (2016) Relationship of hemolysis with discordance in paired activated partial thromboplastin time and anti-Factor Xa measurements in continuous-flow left ventricular assist device patients. J Heart Lung Transplant. 35(11), 1365-1367

Ton VK, Bhonsale A, Gilotra NA et al. (2016) Baseline characteristics predict the presence of amyloid on endomyocardial biopsy. J Card Fail. 23(4), 340-344