Academic Title:
Assistant Professor
Primary Appointment:
Anesthesiology
Location:
MSTF, 5-34
Phone (Primary):
(410) 706-3418
Fax:
(410) 706-2550
Education and Training
Ph.D, Biochemistry and Molecular Biology, University of Massachusetts, Lowell
M.Sc, Medical and Pharmaceutical Research, Free University of Brussels, Belgium
Research/Clinical Keywords
Traumatic brain injury, Alzheimer's disease, Pathophysiology, Neuroprotection, Experimental therapeutics
Highlighted Publications
Tchantchou F, Puche AA, Leiste U, Fourney W, Blanpied TA, Fiskum G. (2018) Rat Model of Brain Injury to Occupants of Vehicles Targeted by Land Mines: Mitigation by Elastomeric Frame Designs. J Neurotrauma. 35(10:1192-1203
Tchantchou F., Fourney W.L, Leiste U.H, Vaughan J., Rangghran P. Puche A., Fiskum G. (2017). Neuropathology and neurobehavioral alterations in a rat model of traumatic brain injury to occupants of vehicles targeted by underbody blasts. Exp. Neurol. 289:9-20
Loane D.J, Stoica B.A, Tchantchou F., Kumar A., Akintola T., Xue F., Conn J.P, Faden A.I (2014).Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental TBI. Neurotherapeutics, 1(4):857-69
Tchantchou F., Tucker L.B, Fu A.H, Bluet R.J, McCabe J.T, Patel S., Zhang Y. (2014). The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. Neuropharmacology, 85:427-39
Tchantchou F., Zhang Y. (2013). Selective inhibition of alpha/beta-hydrolase domain 6 attenuates neurodegeneration, alleviates blood brain barrier breakdown and improves functional recovery in a mouse model of traumatic brain injury. J. Neurotrauma. 30(7):565-79 (Cover page)
Tchantchou F, Xu Y, Wu Y, Christen Y, Luo Y (2007). EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer’s disease. FASEB J. 21(10):2400-8
Tchantchou F. (2006, Review). Homocysteine metabolism and various consequences of folate deficiency. J. Alz Dis. 9(4):421-427
Tchantchou F, Graves M and Shea TB, (2006). Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: Modulation by apolipoprotein E-deficiency. Nutritional Neurosci., 9 (1):17-24
Additional Publication Citations
Book Chapters
Tchantchou F and Shea TB (2008). Folate deprivation, the methionine cycle and Alzheimer's disease, In Litwack G., Eds. Folic Acid and Folates; Vitamins and Hormones, Vol. 79:83-97
Tchantchou F and Shea TB (2005). Interaction between Dietary and Genetic Deficiencies in the Modulation of Homocysteine Elimination, In Luo Y. and Packer L., Eds. Oxidative Stress and Age-Related Neurodegeneration. CRC Press: 443-456
Grants and Contracts
US-DOD-FA8650-17-2-6H10 (01/23/2017-12/31/2021)
Principal Investigator: F. Tchantchou