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Kenichi Tanaka, MD

Academic Title:

Professor

Primary Appointment:

Anesthesiology

Administrative Title:

Division Head, Cardiothoracic Anesthesiology

Location:

UMMC, S8D

Phone (Primary):

(410) 328-9813

Fax:

(410) 328-3092

Biosketch

Dr. Tanaka has received his doctor of medicine degree from Keio University in Tokyo, Japan. He has completed the Anesthesiology residency at University of Pittsburgh Medical Center (1995-1998). He subsequently pursued a clinical fellowship at the Department of Anesthesiology, Emory University School of Medicine (1998-2000). He also obtained the Masters in the Science of Clinical Research from the Graduate School of Emory University (2006). He is a diplomate of the American Board of Anesthesiology (1999).

In 2014, Dr. Tanaka joined the faculty at the University of Maryland School of Medicine (UM SoM) as a professor, and director of Cardiovascular Anesthesiology at University of Maryland Medical Center (UMMC).

Dr. Tanaka currently serves on the editorial boards of British Journal of Anaesthesia (Associate Editor), Anesthesia & Analgesia (Senior Editor), and Journal of Cardiothoracic Vascular Anesthesia. 

Highlighted Publications

  1. McNeil J, Raphael J, Chow JH, Tanaka K, Mazzeffi MA. Antifibrinolytic Drugs and Allogeneic Transfusion In Pediatric Multi-Level Spine Surgery: A Propensity Score Matched Cohort Study. Spine. 45(6), E336-E341. doi: 10.1097/BRS.0000000000003273. PMID: 31574059. 2020
  2. Bolliger D, Tanaka KA. Tranexamic Acid in Vascular Surgery: Antifibrinolytic or Clot-Stabilising Activity. Br J Anaesth. 124(1), 4-6. PMID: 31668952. 2020
  3. Mazzeffi MA, Prakash AP, Bolliger D, Erdoes G, Tanaka KA. The Year in Coagulation: Selected Highlights from 2019. J Cardiothoracic Vasc Anesth. 34(7), 1745-1754. doi: 10.1053/j.jvca.2020.01.045. Epub 2020 Jan 31. PMID: 32115363. 2020
  4. Tanaka KA, Mondal S, Morita Y, Williams B, Strauss ER, Cicardi M. Perioperative Management of Patients With Hereditary Angioedema With Special Considerations for Cardiopulmonary Bypass. Anesth Analg. doi: 10.1213/ANE.0000000000004710. [Epub ahead of print]. PMID: 32102012. 2020
  5. Tanaka KA, Reformato VS, Mazzeffi MA. Propofol-Is She Dr Jekyll or Ms Hyde?. J Cardiothorac Vasc Anesth. 34(1), 307-308. PMID: 31383596. 2020
  6. Grazioli A, Athale J, Tanaka K, Madathil R, Rabin J, Kaczorowski D, Mazzeffi M. Perioperative Applications of Therapeutic Plasma Exchange in Cardiac Surgery: A Narrative Review. J Cardiothorac Vasc Anesth. S1053-0770(20)30118-X. PMID: 32147326. 2020
  7. Strauss ER, Dahmane E, Judd M, Guo D, Williams B, Meyer M, Gammie JS, Taylor BS, Mazzeffi MA, Gobburu JV, Tanaka KA. A Pharmacokinetic and Pharmacodynamic Investigation of an e-Aminocaproic Acid Regimen Designed for Cardiac Surgery With Cardiopulmonary Bypass. J Cardiothorac Vasc Anesth. S1053-0770(20)30721-7. doi: 10.1053/j.jvca.2020.07.048. Online ahead of print. PMID: 32811752. 2020
  8. Tabatabai A, Rabin J, Menaker J, Madathil R, Galvagno S, Menne A, Chow JH, Grazioli A, Herr D, Tanaka K, Scalea T, Mazzeffi M. Factor VIII and functional Protein C activity in critically ill patients with Coronavirus disease. A A Pract. 14(7), e01236. PMID: 32539272. 2020
  9. Mazzeffi MA, Gammie JS, Tanaka K, Holmes SD, Salenger R, Alejo D, Galvagno S, Rock P, Taylor B. Maryland’s Global Budget Revenue Program and coronary artery bypass surgery. Ann Thorac Surg. 110(2), 592-597. doi: 10.1016/j.athoracsur.2019.10.084. Epub 2019 Dec 23. PMID: 31877294. 2020
  10. Tanaka KA, Bollinger D. More Is Not Always Better: Effects of Cell Salvage in Cardiac Surgery on Postoperative Fibrinogen Concentrations. J Cardiothorac Vasc Anesth. 34(9), 2383-2385. doi: 10.1053/j.jvca.2020.03.032. Epub 2020 Apr 15. PMID: 32359708. 2020
  11. Chow JH, Mazzeffi MA, Tanaka KA. In Response. Anesth Analg. doi: 10.1213/ANE.0000000000004721. Online ahead of print. PMID: 32175945. 2020
  12. Madathil R, Tabatabai A, Rabin J, Menne A, Henderson R, Mazzeffi M, Scalea T, Tanaka K. Thromboelastometry and D-Dimer Elevation in Coronavirus-2019. J Cardiothorac Vasc Anesth. S1053-0770(20)30481-X. doi: 10.1053/j.jvca.2020.05.020. Online ahead of print. PMID: 32593588. 2020
  13. Tanaka KA, Henderson RA, Strauss ER. Epub 2020 May 3. Evolution of viscoelastic coagulation testing. Expert Rev Hematol. 13(7), 697-707. doi: 10.1080/17474086.2020.1758929. Epub 2020 May 3. PMID: 32310702. 2020
  14. Mondal S, Dawood M, Bandyopadhyay D, Taylor BS, Tanaka K, Gupta A. Transcatheter aortic valve replacement: A potential option for aortic insufficiency management in patients with left ventricular assist device. Int J Cardiol Heart Vasc. 26, 100425. PMID: 31763439. 2020
  15. Kim J, Nguyen TT, Li Y, Zhang CO, Cha B, Ke Y, Mazzeffi MA, Tanaka KA, Birukova AA, Birukov KG. Contrasting effects of stored allogeneic red blood cells and their supernatants on permeability and inflammatory responses in human pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol. 318(3), L533-L548. PMID: 31913681. 2020
  16. Chow JH, Fedeles B, Richards JE, Tanaka KA, Morrison JJ, Rock P, Scalea TM, Mazzeffi MA. Thromboelastography Reaction-Time Thresholds for Optimal Prediction of Coagulation Factor Deficiency in Trauma. J Am Coll Surg. 230(5), 798-808. PMID: 32142926. 2020
  17. Williams B, Henderson R, Reformato VS, Pham T, Taylor BS, Tanaka KA. Hemostasis Management of Patients Undergoing Emergency Cardiac Surgery After Ticagrelor Loading. J Cardiothorac Vasc Anesth. 34(1):168-174. PMID: 31375405. 2020
  18. Heavner MS, McCurdy MT, Mazzeffi MA, Galvagno SM, Tanaka KA, Chow JH. Angiotensin II and Vasopressin for Vasodilatory Shock: A Critical Appraisal of Catecholamine-Sparing Strategies. J Intensive Care Med. 885066620911601. doi: 10.1177/0885066620911601. Online ahead of print. PMID: 32223515. 2020
  19. Deshpande SP, Sankova S, Dorsey N, Dawood MY, Tanaka K. Transcatheter tricuspid valve-in valve replacement-hope for the forgotten valve!. Korean J Anesthesiol. 73(3), 264-266. doi: 10.4097/kja.20104. Epub 2020 Mar 12. PMID: 32160737. 2020
  20. Mazzeffi M, Chow JH, Amoroso A, Tanaka K. Revisiting the Protein C Pathway: An Opportunity for Adjunctive Intervention in COVID-19?. Anesth Analg. 10.1213/ANE.0000000000005059. doi: 10.1213/ANE.0000000000005059. Online ahead of print. PMID: 32541255. 2020
  21. Mazzeffi MA, Chow JH, Wu ZJ, Tanaka KA. Understanding Extracorporeal Membrane Oxygenation Induced Coagulopathy: Many Pieces to the Puzzle. Crit Care Med. 48(8), e732-e733. PMID: 32697517. 2020
  22. Mazzeffi MA, Chow JH, Tanaka K. COVID-19 Associated Hypercoagulability: Manifestations, Mechanisms, and Management. Shock (Augusta, Ga). DOI: 10.1097/SHK.0000000000001660. 2020
  23. Piacente C, Martucci G, Miceli V, Pavone G, Papeo A, Occhipinti G, Panarello G, Lorusso R, Tanaka K, Arcadipane A. A narrative review of antithrombin use during veno-venous extracorporeal membrane oxygenation in adults: rationale, current use, effects on anticoagulation, and outcomes. Perfusion. 35(6), 452-464. PMID: 32228213. 2020
  24. Mazzeffi M, Bathula A, Tabatabai A, Menaker J, Kaczorowski D, Madathil R, Galvagno S, Pasrija C, Rector R, Tanaka K, Herr D. Von Willebrand Factor Concentrate Administration for Acquired Von Willebrand Syndrome- Related Bleeding During Adult Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. S1053-0770(20), 30627-3. PMID: 32758410. 2020
  25. Chow JH, Abuelkasem E, Sankova S, Henderson RA, Mazzeffi MA, Tanaka KA. Reversal of Vasodilatory Shock: Current Perspectives on Conventional, Rescue, and Emerging Vasoactive Agents for the Treatment of Shock. Anesth Analg. 130(1):15-30. PMID: 31348056. 2020

Research Interests

Dr. Tanaka’s research focuses has mainly focused on coagulation management, blood-less surgery and transfusion as well as clinical outcomes in the setting of cardiovascular surgery. I have participated in both preclinical and clinical studies of novel agents that modulate coagulation, and coagulation monitoring devices. The main focus is to evaluate the dynamic balance of thrombin generation during liver transplantation, and after cardiopulmonary bypass (CPB). To this end, multi-modal approaches to coagulation assessments are utilized; viscoelastic coagulation monitoring devices, fluorogenic thrombin generation assay, flow chamber system, and computer simulation model.

Clinical Specialty Details

  • Blood Conservation in Cardiac Surgery
  • Clinical Diagnosis and Management of Perioperative Coagulopathy

Community Service

Committee on Patient Blood Management for the Americal Society of Anesthesiologists

Lab Techniques and Equipment

1: Calibrated automated thrombin generation assay; 2: rotational thromboelastometry; 3: flow chamber system