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Mark F. Smith, PhD

Academic Title:

Associate Professor

Primary Appointment:

Diagnostic Radiology and Nuclear Medicine

Administrative Title:

Director Of Radiation Physics

Location:

Gudelsky Building, G2J04

Phone (Primary):

410-328-1320

Education and Training

Washington University (St. Louis)     AB                              1979    Physics, Mathematics,

                                                                                                            Germanic Languages and Literatures

University of California, San Diego   PhD                             1989    Earth Sciences

Duke University (Durham, NC)         Postdoctoral Fellow    1992    Nuclear Medicine Physics

Biosketch

Dr. Smith attended Washington University (St. Louis) and received an A.B. in Physics and Mathematics in 1979. He worked as an exploration geophysicist for Gulf Oil Corporation (Houston, TX) from 1980-1985. Dr. Smith received his Ph.D. in 1989 from the University of California, San Diego in Earth Sciences, where he studied seismological imaging of the earth. From 1989-1992 he was a Postdoctoral Fellow in nuclear medicine physics at Duke University in Durham, NC, followed by Assistant Research Professor positions in the Department of Biomedical Engineering at Duke University (1992-1997) and in the Department of Radiology at Duke University Medical Center (1995-1997). Dr. Smith was a Physicist (1998-2000) and Staff Scientist (2000-1001) in the Nuclear Medicine Department of the Clinical Center, National Institutes of Health, Bethesda, MD. He then joined the Detector and Imaging Group in the Physics Division, Thomas Jefferson National Accelerator Facility in Newport News, VA as a Biomedical Imaging Physicist (2001-2007). Dr. Smith moved to the University of Maryland School of Medicine in 2007, where he is an Associate Professor in the Department of Diagnostic Radiology and Nuclear Medicine.

Research/Clinical Keywords

nuclear medicine physics, PET, SPECT, image reconstruction, instrumentation, kinetic modeling, cardiac, cardiovascular, heart, motion correction

Highlighted Publications

Tian J, Smith MF, Ahmad G, Dilsizian V, Jimenez A, Dickfeld T. Integration of 3-dimensional scar models from SPECT to guide ventricular tachycardia ablation. J Nucl Med. 53: 894-901; 2012.

Baba JS, Endres CJ, Foss CA, Nimmagadda S, Jung H, Goddard JS, Lee S, McKisson J, Smith MF, Stolin AV, Weisenberger AG, Pomper MG. Molecular imaging of conscious, unrestrained mice with AwakeSPECT. J Nucl Med. 54: 969-976; 2013.

Smith MF, Gibert-Serra X, Arrate F, Chellappa R, Chodnicki K; Tian J; Dickfeld T, Dilsizian V. CardioViewer: A novel modular software tool for integrating cardiac electrophysiology voltage measurements and PET/SPECT data. 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). Seattle, Washington, November 8-15, 2014. DOI:10.1109/NSSMIC.2014.7430814.

Anishchenko S, Beylin D, Stepanov P, Stepanov A, Weinberg IN, Schaeffer S, Zavarzin V, Shaposhnikov D, Smith MF. Evaluation of a video-based head motion tracking system for dedicated brain PET. Proc SPIE 9412, Medical Imaging 2015: Physics of Medical Imaging, 94121P (March 18, 2015); doi:10.1117/12.2082137.

Additional Publication Citations

1. Smith MF, Masters TG. The effect of Coriolis coupling of free oscillation multiplets on the determination of aspherical earth structure. Geophys Res Lett 1989 16: 263-266

2. Smith MF, Masters TG. Aspherical structure constraints from free oscillation frequency and attenuation measurements. J Geophys Res 1989 94: 1953-1976

3. Smith MF, Floyd CE Jr, Jaszczak RJ, Coleman RE. Reconstruction of SPECT images using generalized matrix inverses. IEEE Trans Med Imaging 1992 11: 165-175

4. Smith MF, Floyd CE Jr, Jaszczak RJ, Coleman RE. Three-dimensional photon detection kernels and their application to SPECT reconstruction. Phys Med Biol 1992 37: 605-622

5. Smith MF, Floyd CE Jr, Jaszczak RJ, Coleman RE. Evaluation of projection pixel-dependent and pixel-independent scatter correction in SPECT. IEEE Trans Nucl Sci 1992 39: 1099-1105

6. Smith MF, Floyd CE Jr, Jaszczak RJ. A vectorized Monte Carlo code for modeling photon transport in SPECT. Med Phys 1993 20: 1121-1127

7. Turkington TG, Gilland DR, Jaszczak RJ, Greer KL, Coleman RE, Smith MF. A direct measurement of skull attenuation for quantitative SPECT. IEEE Trans Nucl Sci 1993 40: 1158- 1161

8. Smith MF. Modelling photon transport in non-uniform media for SPECT with a vectorized Monte Carlo code. Phys Med Biol 1993 38: 1459-1474

9. Smith MF, Jaszczak RJ. Generalized dual-energy-window scatter compensation in spatially varying media for SPECT. Phys Med Biol 1994 39: 531-546

10. Smith MF, Jaszczak RJ. Simultaneously constraining SPECT activity estimates with primary and secondary energy window projection data. IEEE Trans Med Imaging 1994 13: 329-337

11. Smith MF. Out-of-plane photon compensation for 3-D SPECT image reconstruction with generalized matrix inverses. IEEE Trans Nucl Sci 1994 41: 2820-2830

12. Smith MF, Gilland DR, Jaszczak RJ, Coleman RE. Estimation of tumor activities from simulated I-123 SPECT studies. IEEE Trans Nucl Sci 1995 42: 1282-1289

13. Smith MF. Generalized matrix inverse reconstruction for SPECT using a weighted singular value spectrum. IEEE Trans Nucl Sci 1996 43: 2008-2017

14. Smith MF, Jaszczak RJ, Wang H, Li J. Lead and tungsten pinhole inserts for I-131 SPECT tumor imaging: experimental measurements and photon transport simulations. IEEE Trans Nucl Sci 1997 44: 74-82

15. Smith MF, Jaszczak RJ, Wang H. Pinhole aperture design for 131I tumor imaging. IEEE Trans Nucl Sci 1997 44: 1154-1160

16. Peter J, Freyer R, Smith MF, Scarfone C, Coleman RE, Jaszczak RJ. Nuclear medicine image segmentation using a connective network. IEEE Trans Nucl Sci 1997 44: 1583-1590

17. Smith MF, Jaszczak RJ. The effect of gamma ray penetration on angle-dependent sensitivity for pinhole collimation in nuclear medicine. Med Phys 1997 24: 1701-1709

18. Scarfone C, Jaszczak RJ, Li J, Soo MS, Smith MF, Greer KL, Coleman RE. Breast tumor imaging using incomplete circular orbit pinhole SPET: a phantom study. Nucl Med Commun 1997 18: 1077-1086

19. Smith MF, Jaszczak RJ. An analytic model of pinhole aperture penetration for 3-D pinhole SPECT image reconstruction. Phys Med Biol 1998 43: 761-775

20. Smith MF, Gilland DR, Coleman RE, Jaszczak RJ. Quantitative imaging of I-131 distributions in brain tumors with pinhole SPECT: a phantom study. J Nucl Med 1998 39: 856-864

21. Stone CD, Smith MF, Greer KL, Jaszczak RJ. A combined half-cone beam and parallel hole collimation system for SPECT brain imaging. IEEE Trans Nucl Sci 1998 45: 1219-1224

22. Wang H, Smith MF, Stone CD, Jaszczak RJ. Astigmatic SPECT imaging with a displaced center-of-rotation. Med Phys 1998 25: 1493-1501

23. Smith MF, Jaszczak RJ. A rotating parallel hole collimator for high resolution imaging of medium energy radionuclides. IEEE Trans Nucl Sci 1998 45: 2102-2112

24. Mansour PM, Smith MF, Barker WC, Dilsizian V, Srinivasan G, Bacharach SL. Regional left ventricular function from short-duration SPECT gated blood pool studies. IEEE Trans Nucl Sci 1999 46: 680-685

25. Smith MF, Brigger P, Ferrand SK, Dilsizian V, Bacharach SL. Regional cardiac wall motion from gated myocardial perfusion SPECT studies. IEEE Trans Nucl Sci 1999 46: 727-736

26. Tenney CR, Smith MF, Greer KL, Jaszczak RJ. Uranium pinhole collimators for I-131 SPECT imaging. IEEE Trans Nucl Sci 1999 46: 1165-1171

27. Smith MF. The effect of contraction and twist on myocardial PET and SPECT image resolution: a mathematical phantom study. IEEE Trans Nucl Sci 2000 46: 1646-1654

28. Smith MF, Daube-Witherspoon ME, Plascjak PS, Szajek LP, Carson RE, Everett JR, Green SL, Territo PR, Balaban RS, Bacharach SL, Eckelman WC. Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies. Med Phys 2001 28: 36-45

29. Dilsizian V, Bacharach SL, Khin MM, Smith MF. Fluorine-18-deoxyglucose SPECT and coincidence imaging for myocardial viability: clinical and technologic issues. J Nucl Cardiol 2001 8: 75-88

30. Metzler SD, Bowsher JE, Smith MF, Jaszczak RJ. Analytic determination of pinhole collimator sensitivity with penetration. IEEE Trans Med Imaging 2001 20: 730-741

31. Tenney CR, Tornai MP, Smith MF, Turkington TG, Jaszczak RJ. Uranium pinhole collimators for 511-keV photon SPECT imaging of small volumes. IEEE Trans Nucl Sci 2001 48: 1483-1489

32. Bennett SK, Smith MF, Gottlieb SS, Fisher ML, Bacharach SL, Dilsizian V. Effect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy. Am J Cardiol 2002 89: 1431-1434

33. Meikle SR, Kench P, Weisenberger AG, Wojcik R, Smith MF, Majewski S, Eberl S, Fulton RR, Rosenfeld AB, Fulham MJ. A prototype coded aperture detector for small animal SPECT. IEEE Trans Nucl Sci 2002 49: 2167-2171

34. Raylman RR, Majewski S, Smith MF, Wojcik R, Weisenberger AG, Kross B, Popov V, Derakhshan JJ. Comparison of scintillators for positron emission mammography (PEM) systems. IEEE Trans Nucl Sci 2003 50: 42-49

35. Smith MF, Majewski S, Weisenberger AG, Kieper DA, Raylman RR, Turkington TG. Analysis of factors affecting positron emission mammography (PEM) image formation. IEEE Trans Nucl Sci 2003 50: 53-59

36. Weisenberger AG, Wojcik R, Bradley EL, Brewer P, Majewski S, Qian J, Ranck A, Saha MS, Smith K, Smith MF, Welsh RE. SPECT-CT system for small animal imaging. IEEE Trans Nucl Sci 2003 50: 74-79

37. Saha MS, Bradley EL, Brewer P, Gleason KK, Kross B, Majewski S, Popov V, Qian J, Ranck A, Smith K, Smith MF, Weisenberger AG, Wojcik R, Welsh RE. Incorporation of a fluoroscopic X-ray modality in a small animal imaging system. IEEE Trans Nucl Sci 2003 50: 333-338

38. Smith MF, Majewski S, Weisenberger AG. Optimizing pinhole and parallel hole collimation for scintimammography with compact pixellated detectors. IEEE Trans Nucl Sci 2003 50: 321-326

39. Smith MF, Raylman RR, Majewski S, Weisenberger AG. Positron emission mammography with tomographic acquisition using dual planar detectors: initial evaluations. Phys Med Biol 2004 49: 2437-2452

40. Weisenberger AG, Gleason SS, Goddard J, Kross B, Majewski S, Meikle SR, Paulus MJ, Pomper M, Popov V, Smith MF, Welch BL, Wojcik R. A restraint-free small animal SPECT imaging system with motion tracking. IEEE Trans Nucl Sci 2005 52: 638-644

41. Raylman RR, Smith MF, Menge PR. A Monte-Carlo simulation study of detector array design for dedicated breast metabolic imaging systems. Nucl Instrum Meth A 2005 555: 403-410

42. Bradley EL, Cella J, Majewski S, Popov V, Qian J, Saha MS, Smith MF, Weisenberger AG, Welsh RE. A compact gamma camera for biological imaging. IEEE Trans Nucl Sci 2006 53: 59- 65

43. Raylman RR, Majewski S, Kross B, Popov V, Proffitt J, Smith MF, Weisenberger AG, Wojcik R. Development of a dedicated positron emission mammography system for the detection and biopsy of breast cancer. Nucl Instrum Meth A 2006 569: 291-295

44. Raylman RR, Majewski S, Lemieux S, Velan SS, Kross B, Popov V, Smith MF, Weisenberger AG, Wojcik R. Initial tests of a prototype MRI-compatible PET imager. Nucl Instrum Meth A 2006 569: 306-309

45. Raylman RR, Majewski S, Lemieux SK, Velan SS, Kross B, Popov V, Smith MF, Weisenberger AG, Zorn C, Marano GD. Simultaneous MRI and PET imaging of a mouse brain. Phys Med Biol 2006 51: 6371-6379

46. Raylman RR, Smith MF. A task-based evaluation of PEM detector element size. Phys Med 2006 21 Suppl 1: 80-82

47. Hammond WT, Bradley EL, Welsh RE, Qian J, Weisenberger AG, Smith MF, Majewski S, Saha MS. A gamma camera re-evaluation of potassium iodide blocking efficiency in mice. Health Phys 2007 92:396-406

48. Raylman RR, Majewski S, Velan SS, Lemieux S, Kross B, Popov V, Smith MF, Weisenberger AG. Simultaneous acquisition of magnetic resonance spectroscopy (MRS) data and positron emission tomography (PET) images with a prototype MR-compatible, small animal PET imager. J Magn Reson 2007 186(2): 305-310

49. Raylman RR, Majewski S, Smith MF, Proffitt J, Hammond W, Srinivasan A, McKisson J, Popov V, Weisenberger A, Judy CO, Kross B, Ramasubramanian S, Banta LE, Kinahan PE, Champley K. The positron emission mammography/tomography breast imaging and biopsy system (PEM/PET): design, construction and phantom-based measurements. Phys Med Biol 2008 53: 637-653

50. Smith MF. Advances in rubidium PET and integrated imaging with CT angiography. Current Cardiology Reports 2008 53: 135-141

51. Qian J, Bradley EL, Majewski S, Popov V, Saha MS, Smith MF, Weisenberger AG, Welsh RE. A small-animal imaging system capable of multipinhole circular/helical SPECT and parallel-hole SPECT. Nucl Instrum Meth A 2008 594:102-110

52. Raylman RR, Smith MF, Kinahan PE, Majewski S. Quantification of radiotracer uptake with a dedicated breast imaging system. Med Phys 2008 35

53. Tian J, Smith MF, Jeudy J, Dickfeld T. Multimodality fusion imaging using delayed-enhanced cardiac magnetic resonance imaging, computed tomography, positron emission tomography, and real-time intracardiac echocardiography to guide ventricular tachycardia ablation in implantable cardioverter-defibrillator patients. Heart Rhythm 2009 6: 825-828

54. Tian J, Smith MF, Chinnadurai P, Dilsizian V, Turgeman A, Abbo A, Gajera K, Xu C, Plotnick D, Peters R, Saba M, Shorofsky S, Dickfeld T. Clinical application of PET/CT fusion imaging for three-dimensional myocardial scar and left ventricular anatomy during ventricular tachycardia ablation. J Cardiovasc Electrophysiol 2009 20: 597-604

55. Fink JC, Lodge MA, Smith MF, Hinduja A, Brown J, Dinits-Pensy MY, Dilsizian V. Pre-clinical myocardial metabolic alterations in chronic kidney disease. Cardiology 2010 116: 160-167

56. Tian J, Jeudy J, Smith MF, Jimenez A, Yin X, Bruce PA, Lei P, Turgeman A, Abbo A, Shekhar R, Saba M, Shorofsky S, Dickfeld T. Three dimensional contrast enhanced multi-detector CT for anatomic, dynamic and perfusion characterization of abnormal myocardium to guide VT ablation. Circ Arrhythm Electrophysiol 2010 3: 496-504

57. Tian J, Smith MF, Dickfeld T. Clinical application of FDG-PET imaging for three-dimensional myocardial scar and left ventricular anatomy during ventricular tachycardia ablation. PET Clin 2011 . 6: 393-402

58. Weisenberger AG, Lee S, Smith MF. Motion-tracking technique in unrestrained small-animal single-photon emission computed tomography. Rev Neurosci 2011 22: 657-663

59. Tian J, Smith MF, Ahmad G, Dilsizian V, Jimenez A, Dickfeld T. Integration of 3-dimensional scar models from SPECT to guide ventricular tachycardia ablation. J Nucl Med 2012 53: 894-901

60. Weisenberger AG, Kross B, Lee S, McKisson J, McKisson JE, Xi W, Zorn C, Reid C, Howell CR, Crowell AS, Cumberbatch L, Fallin B, Stolin A, Smith MF. PhytoBeta imager: a positron imager for plant biology. Phys Med Biol 2012 57: 4195-4210

61. Baba JS, Endres CJ, Foss CA, Nimmagadda S, Jung H, Goddard JS, Lee S, McKisson J, Smith MF, Stolin AV, Weisenberger AG, Pomper MG. Molecular imaging of conscious, unrestrained mice with AwakeSPECT. J Nucl Med. 54: 969-976; 2013

62. Weisenberger AG, Kross B, Lee SJ, McKisson J, McKisson JE, Xi W, Zorn C, Howell CR, Crowell AS, Reid CD, Smith M. Nuclear physics detector technology applied to plant biology research. Nucl Instrum Meth A. 718: 157-159; 2013

63. Smith MF. Recent advances in cardiac SPECT instrumentation and system design. Curr Cardiol Rep. 15(8): 387; 2013

64. Cao Q, Hersl J, La H, Smith M, Jenkins J, Goloubeva O, Dilsizian V, Tkaczuk K, Chen W, Jones L. A pilot study of FDG PET/CT detects a link between brown adipose tissue and breast cancer. BMC Cancer. 14:126; 2014

65. Abdulghani M, Duell J, Smith M, Chen W, Bentzen SM, Asoglu R, Klein T, Bob-Manuel T, Saliaris A, See V, Shorofsky S, Dilsizian V, Dickfeld T. Global and regional myocardial innervation before and after ablation of drug-refractory ventricular tachycardia assessed with 123I-MIBG. J Nucl Med. 56 Suppl 4:52S-58S; 2015. doi: 10.2967/jnumed.115.155143. PMID 26033905

66. Wawrzyniak AJ, Dilsizian V, Krantz DS, Harris KM, Smith MF, Shankovich A, Whittaker KS, Rodriguez GA, Gottdiener J, Li S, Kop W, Gottlieb SS. High concordance between mental stress-induced and adenosine-induced myocardial ischemia assessed using SPECT in heart failure patients: hemodynamic and biomarker correlates. J Nucl Med. 56: 1527-1533; 2015.

67. Klein T, Abdulghani M, Smith M, Huang R, Asoglu R, Remo BF, Turgeman A, Olurotimi M, Sidhu S, Synowski S, Saliaris A, See V, Shorofsky S, Chen C, Dilsizian V, Dickfeld T. Three-dimensional 123I-meta-iodobenzylguanidine cardiac innervation maps to assess substrate and successful ablation sites for ventricular tachycardia: feasibility study for a novel paradigm on innervation imaging. Circ Arrhythm Electrophysiol. 8: 583-591; 2015. DOI: 10.1161/CIRCEP.114.002105.

68. Duell J, Dilsizian V, Smith M, Chen W, Dickfeld T. Nuclear imaging guidance for ablation of ventricular arrhythmias. Curr Cardiol Rep. 18:19; 2016. DOI: 10.1007/s11886-015-0697-2.

69. Raylman RR, Stolin AV, Martone PF, Smith MF. Tandem-PET: a high resolution, small animal, virtual pinhole-based PET scanner: initial design study. IEEE Trans Nucl Sci. 63: 75-83; 2016. DOI: 10.1109/TNS.2015.2482459.

Awards and Affiliations

Board certified by the American Board of Science in Nuclear Medicine (ABSNM), specialty area Nuclear Medicine Physics and Instrumentation