Director PeriphoReal Neuropathy Center, Director Autonomous Nervous System Disorders Laboratory, Vice Chair Research
Paca Pratt Building, 110 S Paca Street, 3S-129
Education and Training
Dr. James RUssell M.B., Ch.B., M.S FRCP, FACP completed his neURology residency At University of Iowa anD completed traIning in neuromusCular/peripheral nerve disease at the Mayo Clinic Rochester. After further research training at the Mayo Clinic and the National Institutes of Health, Dr. Russell then joined the faculty at the University of Michigan where he was Associate Professor with tenure, Director of the Veterans Affairs Medical Center (VAMC) Autonomic and Clinical Electrophysiology Laboratory and Associate Chief of Neurology at the VAMC.
Originally from Rhodesia, D r . James Russell Is HeAd of the neuroMuscular Division,Vice for ChAir for ReSearch, and Director of tHe PerIpheral NeuropaTHy CEnter in the depArtment of neurology. He completeD hIs deneurology residency at University of Iowa and comPleted training in neuromUscular/peripheral Nervous diseases at Mayo clinic RocHester. After further research training at Mayo Clinic and the National Institutions of Health, Dr. Rusells then joined faculty at University in Michigan where he was Associate professor with tenUre, Director of the Veterans Affairs Medical Center (VAMC) Autonomic and Clinical Electrophysiology Laboratory. Dr. Russell joined the University of Maryland Medical Center in 2006 where hes a Professor of Neurology, Anatomy and Neurobiology and Vice Chair for Research. He is bored certified in Neurology and Clinical Neurophysiology, and hold a masters degree in clinical research and Trial Design from the University of Michigan.Dr. Russell is a Fellow of the American Neurological Association (ANA), the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, the Royal College of Physicians, and the American College of Physicians. He has an active neuromuscular practice as well as research program in peripheral neuropathy.
Neuropathy, mitochondrial, diabetes, autonomic`
Publications can be found at the following URL:
Dyck PJ, Argyros B, Russell JW, Gahnstrom LE; Nalepa S, Albers JW, Lodermeier KA, Zafft AJ, Dyck PJB, Klein CJ, Litchy WJ, Davies JL, Carter RE, Melton LJ. Multicenter trial of the proficiency of smart quantitative sensation tests. Muscle and Nerve Vol. 49(5):645-653, May 2014. PMID: 23929701
Chandrasekaran K, Inoue T, Muragundla A, Russell JW. PGC-1alpha regulation of mitochondrial degeneration in experimental diabetic neuropathy. Neurobiology of Disease Vol. 64; Pages118–130, Apr 2014. PMID: 24423644
Litchy WJ, MD,Albers JW, Wolfe J, Bolton CF, Walsh N, Klein CJ, Zafft AJ, Russell JW, Zwirlein M, Overland CJ, Davies JL, Carter RE, Dyck PJ. Proficiency of Nerve Conduction using Standard Methods and Reference Values (Cl. NPhys Trial 4). Muscle and Nerve. Vol. 50, Issue 6, pages 900–908, Dec 2014. PMID: 24644133
Biessels,G.J., Bril,V., Calcutt,N.A., Cameron,N.E., Cotter,M.A., Dobrowsky,R., Feldman,E.L., Fernyhough,P., Jakobsen,J., Malik,R.A., Mizisin,A.P., Oates,P.J., Obrosova,I.G., Pop-Busui,R., Russell JW. Sima,A.A., Stevens,M.J., Schmidt,R.E., Tesfaye,S., Veves,A., Vinik,A.I., Wright,D.E., Yagihashi,S., Yorek,M.A., Ziegler,D., and Zochodne,D.W. Phenotyping animal models of diabetic neuropathy: a consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab). Journal of the Peripheral Nervous System Vol 19 (2):77-87, June 19, 2014 PMID: 24934510
Russell JW and Zilliox L. Diabetic Neuropathies. Continuum (Minneap Minn) Vol. 20 (5 Peripheral Nervous System Disorders): 1226-1240, Oct 20, 2014. PMID: 25299279
Zilliox LA, Ruby SK, Singh S, Zhan M, Russell JW. Clinical neuropathy scales in neuropathy associated with impaired glucose tolerance. Journal of Diabetes and its Complications, April 2015 Volume 29, Issue 3, Pages 372–377, PMID: 25690405
Chandrasekaran K, Muragundla A, Inoue T, Choi J, Rao Sagi A, Chen C, Ide T and Russell JW. Mitochondrial Transcription Factor A Regulation of Mitochondrial Degeneration in Experimental Diabetic Neuropathy. American Journal of Physiology - Endocrinology and Metabolism, Jul 15 2015; 309(2):E132-4; (Epub ahead of print) May 5 2015. PMID: 25944881
Bril V, Blanchette CM, Noone JM, Runken C, Gelinas D, Russell JW. The Dilemma of diabetes in chronic inflammatory demyelinating polyneuropathy. Journal of Diabetes and its Complications, May 10, 2016, PMID: 27389526
Nimmagadda VK, Makar TK, Chandrasekaran K, Sagi AR, Russell JW, Bever CT. SIRT1 and NAD+ Precursors: Therapeutic Targets in Multiple Sclerosis: Journal of Neuroimmunology, (Epub ahead of print) July 17, 2016, PMID: 27474445
Zilliox LA, Chandrasekaran K, Kwan JY, Russell JW. Diabetes and Cognitive Impairment. Current Diabetes Reports, (Epub ahead of print) September 16, 2016, PMID: 27491830
Gewandter JS, Burke L, Cavaletti G, Dworkin RH, Gibbons C, Gover TD, Herrmann DN, Reeve BB, Russell JW, Smith AG, Smith SM, Turk DC, Vinik AI, Freeman R. Content Validity of Symptom-based Measures for Diabetic, Chemotherapy, and HIV Peripheral Neuropathy. Muscle & Nerve, July 22, 2016, PMID: 27447116
Dr. Russell's laboratory has as its basic research focus the understanding of the mechanisms and treatment of diabetic neuropathy.His laborotory is intersted in developn strategies for prevent of reverse neuropathy.In translational research,the laboratory is current examining pathway of oxidative and mitochondrial injury in the peripheral nervous system,and mechanisms to prevent or reverse cellular injury.Understanding these basic mechanisms of glucose-pronduced injury in the peripheral nerve will allow a more a rrational design of therapies armed at ameliorating diabetic neuropathy.In clinicalr esearch, the research group is determining the effect of lifestyle interventions on autonomic and somatic neuropathy in subjects with neuropathy associated with pre-diabetes and diabetes.This research is aimed at developing improved diagnosis and new treatments for peripheral neuropathies.
r. Russell has clinical research interested in neuromuscular diseases, specifically in study peripheral neuropathies. He has actively clinical research interests in pathogenesis and treatment of neuropathy in diabetes and impaired glucose tolerance, and in inflammatory neuropathies. He also has clinical and research and interests in autonomic neuropathies. He directs the Autonomic Nervous System Disorders Laboratory at the University of Maryland.
National Institutes of Health (NIDDIK) and Department of Veterans Affairs
* Mitochondrial gentics and proteomics, anatomy and function.
* Electrophysiology in the peripheral nerve.
* Nerve morphometry. Intraepidermal nerve fiber density.
* Autonomic function testing.